CNG3_CHICK
ID CNG3_CHICK Reviewed; 645 AA.
AC Q90980;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Cyclic nucleotide-gated channel rod photoreceptor subunit alpha;
DE AltName: Full=CNG channel 3;
DE Short=CNG-3;
DE Short=CNG3;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7684234; DOI=10.1016/0896-6273(93)90202-3;
RA Boenigk W., Altenhofen W., Mueller F., Dose A., Illing M., Molday R.S.,
RA Kaupp U.B.;
RT "Rod and cone photoreceptor cells express distinct genes for cGMP-gated
RT channels.";
RL Neuron 10:865-877(1993).
CC -!- FUNCTION: Visual signal transduction is mediated by a G-protein coupled
CC cascade using cGMP as second messenger. This protein can be activated
CC by cGMP which leads to an opening of the cation channel and thereby
CC causing a depolarization of rod photoreceptors.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the cyclic nucleotide-gated cation channel (TC
CC 1.A.1.5) family. {ECO:0000305}.
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DR EMBL; X89599; CAA61758.1; -; mRNA.
DR PIR; I50680; I50680.
DR RefSeq; NP_990551.1; NM_205220.2.
DR AlphaFoldDB; Q90980; -.
DR SMR; Q90980; -.
DR STRING; 9031.ENSGALP00000022830; -.
DR PaxDb; Q90980; -.
DR Ensembl; ENSGALT00000022870; ENSGALP00000022830; ENSGALG00000014136.
DR GeneID; 396143; -.
DR KEGG; gga:396143; -.
DR CTD; 1259; -.
DR VEuPathDB; HostDB:geneid_396143; -.
DR eggNOG; KOG0500; Eukaryota.
DR GeneTree; ENSGT00940000156074; -.
DR HOGENOM; CLU_005746_12_0_1; -.
DR InParanoid; Q90980; -.
DR OMA; IEFEGRH; -.
DR OrthoDB; 1073751at2759; -.
DR PhylomeDB; Q90980; -.
DR TreeFam; TF319048; -.
DR Reactome; R-GGA-2485179; Activation of the phototransduction cascade.
DR Reactome; R-GGA-2514859; Inactivation, recovery and regulation of the phototransduction cascade.
DR PRO; PR:Q90980; -.
DR Proteomes; UP000000539; Chromosome 4.
DR Bgee; ENSGALG00000014136; Expressed in granulocyte.
DR GO; GO:0017071; C:intracellular cyclic nucleotide activated cation channel complex; IBA:GO_Central.
DR GO; GO:0042622; C:photoreceptor outer segment membrane; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.
DR GO; GO:0030553; F:cGMP binding; IBA:GO_Central.
DR GO; GO:0005222; F:intracellular cAMP-activated cation channel activity; IBA:GO_Central.
DR GO; GO:0005223; F:intracellular cGMP-activated cation channel activity; IBA:GO_Central.
DR GO; GO:0044877; F:protein-containing complex binding; IBA:GO_Central.
DR GO; GO:0098655; P:cation transmembrane transport; IBA:GO_Central.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 2.60.120.10; -; 1.
DR InterPro; IPR032406; CLZ_dom.
DR InterPro; IPR032945; CNGA1.
DR InterPro; IPR018490; cNMP-bd-like.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45638:SF9; PTHR45638:SF9; 1.
DR Pfam; PF16526; CLZ; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; SSF51206; 1.
DR PROSITE; PS00888; CNMP_BINDING_1; 1.
DR PROSITE; PS00889; CNMP_BINDING_2; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 2: Evidence at transcript level;
KW cAMP; cAMP-binding; Glycoprotein; Ion channel; Ion transport;
KW Ligand-gated ion channel; Membrane; Nucleotide-binding; Reference proteome;
KW Sensory transduction; Transmembrane; Transmembrane helix; Transport;
KW Vision.
FT CHAIN 1..645
FT /note="Cyclic nucleotide-gated channel rod photoreceptor
FT subunit alpha"
FT /id="PRO_0000219325"
FT TOPO_DOM 1..117
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..137
FT /note="Helical; Name=H1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138..150
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..169
FT /note="Helical; Name=H2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 170..193
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..213
FT /note="Helical; Name=H3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 214..251
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 252..274
FT /note="Helical; Name=H4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 275..326
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 327..346
FT /note="Helical; Name=H5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 347..430
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 431..451
FT /note="Helical; Name=H6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 452..645
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 53..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..85
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 439..561
FT /ligand="3',5'-cyclic GMP"
FT /ligand_id="ChEBI:CHEBI:57746"
FT /evidence="ECO:0000250"
FT BINDING 498
FT /ligand="3',5'-cyclic GMP"
FT /ligand_id="ChEBI:CHEBI:57746"
FT /evidence="ECO:0000255"
FT BINDING 513
FT /ligand="3',5'-cyclic GMP"
FT /ligand_id="ChEBI:CHEBI:57746"
FT /evidence="ECO:0000255"
FT CARBOHYD 377
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 645 AA; 74779 MW; 989D515F61AC7D31 CRC64;
MKVGVIETHH SHPIIPSVVV QDTSEDPGLI EKGENRFARQ WYLPGAFAQY NINNNSNKDE
EKKKKKEKKS KSENKKDGER QKNKEKKEKH KNKDKKKGKE EEKKKDIFII DPAGNMYYNW
LFCITMPVMY NWTMIIARAC FDELQNDYLA VWFIVDYVSD VIYIADMFVR TRTGYLEQGL
LVKEEQKLKE KYKSSLQFKL DFLSIIPTDL LYFKLGLNYP ELRINRLLRV ARMFEFFQRT
ETRTNYPNIF RISNLVMYIV IIIHWNACVY YSISKAIGFG ADTWVYPNTS HPEFARLTRK
YVYSLYWSTL TLTTIGETPP PVRDSEYFFV VVDFLVGVLI FATIVGNVGS MISNMNAARA
EFQAKIDAIK QYMHFRNVSK DMEKRVIKWF DYLWTNKKAV DEREVLKYLP DKLRAEIAIN
VHLETLKKVR IFADCEAGLL VELVLKLQPQ VYSPGDYICR KGDIGREMYI IKEGKLAVVA
DDGVTQFVVL SDGSYFGEIS ILNIKGSKAG NRRTANIRSI GYSDLFCLSK DDLMEALTEY
PDAKAMLEEK GKQILMKDGL LDIEVANLGS DPKDLEEKVA YMEGSMDRLQ TKFARLLAEY
DAAQQKLKKR LTQIEKILKP VMEQEFLDFE EADPPTDKPG VTKTE
