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ACKR1_HUMAN
ID   ACKR1_HUMAN             Reviewed;         336 AA.
AC   Q16570; A8YPG5; O75898; Q16300; Q8WWE3; Q9UJP0; Q9UKZ5; Q9UKZ6; Q9UQE1;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 3.
DT   03-AUG-2022, entry version 187.
DE   RecName: Full=Atypical chemokine receptor 1;
DE   AltName: Full=Duffy antigen/chemokine receptor;
DE   AltName: Full=Fy glycoprotein;
DE            Short=GpFy;
DE   AltName: Full=Glycoprotein D;
DE   AltName: Full=Plasmodium vivax receptor;
DE   AltName: CD_antigen=CD234;
GN   Name=ACKR1; Synonyms=DARC, FY, GPD;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE, AND
RP   VARIANT ASP-42.
RC   TISSUE=Bone marrow;
RX   PubMed=8248172; DOI=10.1073/pnas.90.22.10793;
RA   Chaudhuri A., Polyakova J., Zbrzezna V., Williams K., Gulati S., Pogo A.;
RT   "Cloning of glycoprotein D cDNA, which encodes the major subunit of the
RT   Duffy blood group system and the receptor for the Plasmodium vivax malaria
RT   parasite.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:10793-10797(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ASP-42.
RC   TISSUE=Blood;
RX   PubMed=7663520; DOI=10.1038/ng0695-224;
RA   Tournamille C., Colin Y., Cartron J.-P., Le van Kim C.;
RT   "Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid
RT   gene expression in Duffy-negative individuals.";
RL   Nat. Genet. 10:224-228(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Blood;
RX   PubMed=7833467;
RA   Iwamoto S., Omi T., Kajii E., Ikemoto S.;
RT   "Genomic organization of the glycoprotein D gene: Duffy blood group Fya/Fyb
RT   alloantigen system is associated with a polymorphism at the 44-amino acid
RT   residue.";
RL   Blood 85:622-626(1995).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2), AND VARIANTS ASP-42; CYS-89
RP   AND THR-100.
RC   TISSUE=Blood;
RX   PubMed=9731074;
RA   Tournamille C., Le Van Kim C., Gane P., Le Pennec P.Y., Roubinet F.,
RA   Babinet J., Cartron J.-P., Colin Y.;
RT   "Arg89Cys substitution results in very low membrane expression of the Duffy
RT   antigen/receptor for chemokines in Fy(x) individuals.";
RL   Blood 92:2147-2156(1998).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANTS ASP-42; CYS-89 AND
RP   THR-100.
RX   PubMed=9886340; DOI=10.1046/j.1365-2141.1998.01083.x;
RA   Olsson M.L., Smythe J.S., Hansson C., Poole J., Mallinson G., Jones J.,
RA   Avent N.D., Daniels G.;
RT   "The Fy(x) phenotype is associated with a missense mutation in the Fy(b)
RT   allele predicting Arg89Cys in the Duffy glycoprotein.";
RL   Br. J. Haematol. 103:1184-1191(1998).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT PHE-326.
RC   TISSUE=Peripheral blood;
RA   Doescher A.;
RT   "New polymorphisms in DARC.";
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT PHE-326.
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [9]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-117 (ISOFORMS 1 AND 2).
RX   PubMed=10570183; DOI=10.1073/pnas.96.24.13973;
RA   Zimmerman P.A., Woolley I., Masinde G.L., Miller S.M., McNamara D.T.,
RA   Hazlett F., Mgone C.S., Alpers M.P., Genton B., Boatin B.A., Kazura J.W.;
RT   "Emergence of FY*A(null) in a Plasmodium vivax-endemic region of Papua New
RT   Guinea.";
RL   Proc. Natl. Acad. Sci. U.S.A. 96:13973-13977(1999).
RN   [10]
RP   DISULFIDE BONDS, AND GLYCOSYLATION AT ASN-16.
RX   PubMed=12956774; DOI=10.1046/j.1365-2141.2003.04533.x;
RA   Tournamille C., Filipe A., Wasniowska K., Gane P., Lisowska E.,
RA   Cartron J.-P., Colin Y., Le Van Kim C.;
RT   "Structure-function analysis of the extracellular domains of the Duffy
RT   antigen/receptor for chemokines: characterization of antibody and chemokine
RT   binding sites.";
RL   Br. J. Haematol. 122:1014-1023(2003).
RN   [11]
RP   POLYMORPHISM, AND INVOLVEMENT IN RESISTANCE TO MALARIA.
RX   PubMed=17389925; DOI=10.1371/journal.pone.0000336;
RA   Kasehagen L.J., Mueller I., Kiniboro B., Bockarie M.J., Reeder J.C.,
RA   Kazura J.W., Kastens W., McNamara D.T., King C.H., Whalen C.C.,
RA   Zimmerman P.A.;
RT   "Reduced Plasmodium vivax erythrocyte infection in PNG Duffy-negative
RT   heterozygotes.";
RL   PLoS ONE 2:E336-E336(2007).
RN   [12]
RP   REVIEW.
RX   PubMed=20373092; DOI=10.1007/82_2010_19;
RA   Bonecchi R., Savino B., Borroni E.M., Mantovani A., Locati M.;
RT   "Chemokine decoy receptors: structure-function and biological properties.";
RL   Curr. Top. Microbiol. Immunol. 341:15-36(2010).
RN   [13]
RP   REVIEW.
RX   PubMed=22912641; DOI=10.3389/fimmu.2012.00266;
RA   Novitzky-Basso I., Rot A.;
RT   "Duffy antigen receptor for chemokines and its involvement in patterning
RT   and control of inflammatory chemokines.";
RL   Front. Immunol. 3:266-266(2012).
RN   [14]
RP   REVIEW.
RX   PubMed=22698181; DOI=10.1016/j.imlet.2012.04.004;
RA   Graham G.J., Locati M., Mantovani A., Rot A., Thelen M.;
RT   "The biochemistry and biology of the atypical chemokine receptors.";
RL   Immunol. Lett. 145:30-38(2012).
RN   [15]
RP   REVIEW.
RX   PubMed=23356288; DOI=10.1042/bst20120246;
RA   Cancellieri C., Vacchini A., Locati M., Bonecchi R., Borroni E.M.;
RT   "Atypical chemokine receptors: from silence to sound.";
RL   Biochem. Soc. Trans. 41:231-236(2013).
RN   [16]
RP   VARIANT ASP-42.
RC   TISSUE=Peripheral blood;
RX   PubMed=7705836; DOI=10.1007/bf00208965;
RA   Tournamille C., Le van Kim C., Gane P., Cartron J.-P., Colin Y.;
RT   "Molecular basis and PCR-DNA typing of the Fya/fyb blood group
RT   polymorphism.";
RL   Hum. Genet. 95:407-410(1995).
RN   [17]
RP   VARIANT CYS-89.
RX   PubMed=9746760;
RA   Parasol N., Reid M., Rios M., Castilho L., Harari I., Kosower N.S.;
RT   "A novel mutation in the coding sequence of the FY*B allele of the Duffy
RT   chemokine receptor gene is associated with an altered erythrocyte
RT   phenotype.";
RL   Blood 92:2237-2243(1998).
RN   [18]
RP   INVOLVEMENT IN WBCQ1.
RX   PubMed=18179887; DOI=10.1016/j.ajhg.2007.09.003;
RA   Nalls M.A., Wilson J.G., Patterson N.J., Tandon A., Zmuda J.M.,
RA   Huntsman S., Garcia M., Hu D., Li R., Beamer B.A., Patel K.V.,
RA   Akylbekova E.L., Files J.C., Hardy C.L., Buxbaum S.G., Taylor H.A.,
RA   Reich D., Harris T.B., Ziv E.;
RT   "Admixture mapping of white cell count: genetic locus responsible for lower
RT   white blood cell count in the Health ABC and Jackson Heart Studies.";
RL   Am. J. Hum. Genet. 82:81-87(2008).
RN   [19]
RP   ERRATUM OF PUBMED:18179887.
RA   Nalls M.A., Wilson J.G., Patterson N.J., Tandon A., Zmuda J.M.,
RA   Huntsman S., Garcia M., Hu D., Li R., Beamer B.A., Patel K.V.,
RA   Akylbekova E.L., Files J.C., Hardy C.L., Buxbaum S.G., Taylor H.A.,
RA   Reich D., Harris T.B., Ziv E.;
RL   Am. J. Hum. Genet. 82:532-532(2008).
CC   -!- FUNCTION: Atypical chemokine receptor that controls chemokine levels
CC       and localization via high-affinity chemokine binding that is uncoupled
CC       from classic ligand-driven signal transduction cascades, resulting
CC       instead in chemokine sequestration, degradation, or transcytosis. Also
CC       known as interceptor (internalizing receptor) or chemokine-scavenging
CC       receptor or chemokine decoy receptor. Has a promiscuous chemokine-
CC       binding profile, interacting with inflammatory chemokines of both the
CC       CXC and the CC subfamilies but not with homeostatic chemokines. Acts as
CC       a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13,
CC       CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC
CC       and also for the malaria parasites P.vivax and P.knowlesi. May regulate
CC       chemokine bioavailability and, consequently, leukocyte recruitment
CC       through two distinct mechanisms: when expressed in endothelial cells,
CC       it sustains the abluminal to luminal transcytosis of tissue-derived
CC       chemokines and their subsequent presentation to circulating leukocytes;
CC       when expressed in erythrocytes, serves as blood reservoir of cognate
CC       chemokines but also as a chemokine sink, buffering potential surges in
CC       plasma chemokine levels.
CC   -!- INTERACTION:
CC       Q16570-1; P22290: PVDR; Xeno; NbExp=3; IntAct=EBI-15935975, EBI-15935953;
CC       Q16570-2; P51681: CCR5; NbExp=3; IntAct=EBI-21403047, EBI-489374;
CC   -!- SUBCELLULAR LOCATION: Early endosome. Recycling endosome. Membrane;
CC       Multi-pass membrane protein. Note=Predominantly localizes to endocytic
CC       vesicles, and upon stimulation by the ligand is internalized via
CC       caveolae. Once internalized, the ligand dissociates from the receptor,
CC       and is targeted to degradation while the receptor is recycled back to
CC       the cell membrane.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=2;
CC         IsoId=Q16570-1; Sequence=Displayed;
CC       Name=1;
CC         IsoId=Q16570-2; Sequence=VSP_001323;
CC   -!- TISSUE SPECIFICITY: Found in adult kidney, adult spleen, bone marrow
CC       and fetal liver. In particular, it is expressed along postcapillary
CC       venules throughout the body, except in the adult liver. Erythroid cells
CC       and postcapillary venule endothelium are the principle tissues
CC       expressing duffy. Fy(-A-B) individuals do not express duffy in the bone
CC       marrow, however they do, in postcapillary venule endothelium.
CC   -!- POLYMORPHISM: DARC is responsible for the Duffy blood group system (FY)
CC       [MIM:110700]. The molecular basis of the Fy(A)=Fy1/Fy(B)=Fy2 blood
CC       group antigens is a single variation in position 42; Gly-42 corresponds
CC       to Fy(A) and Asp-42 to Fy(B). Individuals that do not produce the Duffy
CC       antigen (FY(A-B-)) are more resistant to infection by the malarial
CC       parasite Plasmodium vivax. This allele is found predominantly in
CC       population of African origin [MIM:611162].
CC   -!- POLYMORPHISM: Genetic variations in DARC define the white blood cell
CC       count quantitative trait locus 1 (WBCQ1) [MIM:611862]. Peripheral white
CC       blood cell count (WBC) is a common clinical measurement, used to
CC       determine evidence of acute inflammation or infection. Peripheral WBC
CC       is the sum of several cell types including neutrophils and lymphocytes,
CC       which are the most common types of WBC, as well as less common cell
CC       types such as eosinophils, basophils, and monocytes. Elevated WBC has
CC       been associated with risk of coronary heart disease, cancer, and all-
CC       cause mortality. White blood cell levels have widespread clinical
CC       applications including assessment of patients undergoing chemotherapy
CC       and evaluation of infection.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       Atypical chemokine receptor subfamily. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=dbRBC/BGMUT; Note=Blood group antigen gene mutation
CC       database;
CC       URL="https://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=duffy";
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=Duffy antigen entry;
CC       URL="https://en.wikipedia.org/wiki/Duffy_antigen";
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DR   EMBL; U01839; AAC50055.1; -; mRNA.
DR   EMBL; X85785; CAA59770.1; -; Genomic_DNA.
DR   EMBL; S76830; AAB33239.1; -; Genomic_DNA.
DR   EMBL; AF055992; AAC72301.1; -; Genomic_DNA.
DR   EMBL; AF030521; AAD20435.1; -; mRNA.
DR   EMBL; AM887935; CAP12644.1; -; Genomic_DNA.
DR   EMBL; AL035403; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC017817; AAH17817.1; -; mRNA.
DR   EMBL; AF100634; AAF02415.1; -; Genomic_DNA.
DR   EMBL; AF100634; AAF02416.1; -; Genomic_DNA.
DR   CCDS; CCDS1183.1; -. [Q16570-1]
DR   CCDS; CCDS44252.1; -. [Q16570-2]
DR   PIR; I52608; I52608.
DR   RefSeq; NP_001116423.1; NM_001122951.2. [Q16570-2]
DR   RefSeq; NP_002027.2; NM_002036.3. [Q16570-1]
DR   PDB; 4NUU; X-ray; 1.95 A; C=16-43.
DR   PDB; 4NUV; X-ray; 2.60 A; C/D=14-43.
DR   PDB; 7P93; X-ray; 1.55 A; B/M=34-46.
DR   PDBsum; 4NUU; -.
DR   PDBsum; 4NUV; -.
DR   PDBsum; 7P93; -.
DR   AlphaFoldDB; Q16570; -.
DR   SMR; Q16570; -.
DR   BioGRID; 108808; 3.
DR   DIP; DIP-3783N; -.
DR   IntAct; Q16570; 3.
DR   MINT; Q16570; -.
DR   STRING; 9606.ENSP00000357103; -.
DR   ChEMBL; CHEMBL2321626; -.
DR   TCDB; 9.A.14.13.34; the g-protein-coupled receptor (gpcr) family.
DR   GlyGen; Q16570; 2 sites.
DR   iPTMnet; Q16570; -.
DR   PhosphoSitePlus; Q16570; -.
DR   BioMuta; ACKR1; -.
DR   DMDM; 67476970; -.
DR   jPOST; Q16570; -.
DR   MassIVE; Q16570; -.
DR   PaxDb; Q16570; -.
DR   PeptideAtlas; Q16570; -.
DR   PRIDE; Q16570; -.
DR   ProteomicsDB; 60923; -. [Q16570-1]
DR   ProteomicsDB; 60924; -. [Q16570-2]
DR   ABCD; Q16570; 1 sequenced antibody.
DR   Antibodypedia; 2945; 537 antibodies from 41 providers.
DR   DNASU; 2532; -.
DR   Ensembl; ENST00000368121.6; ENSP00000357103.2; ENSG00000213088.12. [Q16570-2]
DR   Ensembl; ENST00000368122.4; ENSP00000357104.1; ENSG00000213088.12. [Q16570-1]
DR   Ensembl; ENST00000537147.5; ENSP00000441985.1; ENSG00000213088.12. [Q16570-1]
DR   GeneID; 2532; -.
DR   KEGG; hsa:2532; -.
DR   MANE-Select; ENST00000368122.4; ENSP00000357104.1; NM_002036.4; NP_002027.2.
DR   CTD; 2532; -.
DR   DisGeNET; 2532; -.
DR   GeneCards; ACKR1; -.
DR   HGNC; HGNC:4035; ACKR1.
DR   HPA; ENSG00000213088; Tissue enhanced (adipose tissue, breast).
DR   MalaCards; ACKR1; -.
DR   MIM; 110700; phenotype.
DR   MIM; 611162; phenotype.
DR   MIM; 611862; phenotype.
DR   MIM; 613665; gene.
DR   neXtProt; NX_Q16570; -.
DR   OpenTargets; ENSG00000213088; -.
DR   PharmGKB; PA28451; -.
DR   VEuPathDB; HostDB:ENSG00000213088; -.
DR   eggNOG; ENOG502SNW7; Eukaryota.
DR   GeneTree; ENSGT00390000006372; -.
DR   HOGENOM; CLU_813693_0_0_1; -.
DR   InParanoid; Q16570; -.
DR   OMA; FHWQLCP; -.
DR   PhylomeDB; Q16570; -.
DR   TreeFam; TF105419; -.
DR   PathwayCommons; Q16570; -.
DR   Reactome; R-HSA-375276; Peptide ligand-binding receptors.
DR   SignaLink; Q16570; -.
DR   BioGRID-ORCS; 2532; 11 hits in 1059 CRISPR screens.
DR   ChiTaRS; ACKR1; human.
DR   GeneWiki; Duffy_antigen_system; -.
DR   GenomeRNAi; 2532; -.
DR   Pharos; Q16570; Tbio.
DR   PRO; PR:Q16570; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q16570; protein.
DR   Bgee; ENSG00000213088; Expressed in vena cava and 168 other tissues.
DR   ExpressionAtlas; Q16570; baseline and differential.
DR   Genevisible; Q16570; HS.
DR   GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0055037; C:recycling endosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0019957; F:C-C chemokine binding; IPI:BHF-UCL.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0038023; F:signaling receptor activity; TAS:ProtInc.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc.
DR   GO; GO:0070098; P:chemokine-mediated signaling pathway; IEA:InterPro.
DR   GO; GO:0006952; P:defense response; NAS:UniProtKB.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0032642; P:regulation of chemokine production; IBA:GO_Central.
DR   InterPro; IPR005384; Duffy_chemokine_rcpt.
DR   PANTHER; PTHR14181; PTHR14181; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Alternative splicing; Blood group antigen;
KW   Direct protein sequencing; Disulfide bond; Endosome;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW   Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..336
FT                   /note="Atypical chemokine receptor 1"
FT                   /id="PRO_0000152585"
FT   TOPO_DOM        1..63
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        64..84
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        85..95
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..116
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        117..129
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        130..153
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        154..166
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..187
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        188..207
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        208..228
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        229..244
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        245..265
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        266..287
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        288..308
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        309..336
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        16
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000269|PubMed:12956774"
FT   CARBOHYD        33
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        51..276
FT                   /evidence="ECO:0000269|PubMed:12956774"
FT   DISULFID        129..195
FT                   /evidence="ECO:0000269|PubMed:12956774"
FT   VAR_SEQ         1..7
FT                   /note="MGNCLHR -> MASSGYVLQ (in isoform 1)"
FT                   /evidence="ECO:0000303|PubMed:8248172,
FT                   ECO:0000303|PubMed:9886340"
FT                   /id="VSP_001323"
FT   VARIANT         42
FT                   /note="G -> D (antigen Fy(b); dbSNP:rs12075)"
FT                   /evidence="ECO:0000269|PubMed:7663520,
FT                   ECO:0000269|PubMed:7705836, ECO:0000269|PubMed:8248172,
FT                   ECO:0000269|PubMed:9731074, ECO:0000269|PubMed:9886340"
FT                   /id="VAR_003480"
FT   VARIANT         89
FT                   /note="R -> C (antigen Fy(x); dbSNP:rs34599082)"
FT                   /evidence="ECO:0000269|PubMed:9731074,
FT                   ECO:0000269|PubMed:9746760, ECO:0000269|PubMed:9886340"
FT                   /id="VAR_015068"
FT   VARIANT         100
FT                   /note="A -> T (in dbSNP:rs13962)"
FT                   /evidence="ECO:0000269|PubMed:9731074,
FT                   ECO:0000269|PubMed:9886340"
FT                   /id="VAR_015069"
FT   VARIANT         203
FT                   /note="L -> Q (in dbSNP:rs3027020)"
FT                   /id="VAR_044116"
FT   VARIANT         326
FT                   /note="S -> F (in dbSNP:rs17851570)"
FT                   /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.6"
FT                   /id="VAR_044117"
FT   HELIX           22..28
FT                   /evidence="ECO:0007829|PDB:4NUU"
SQ   SEQUENCE   336 AA;  35553 MW;  C3F2A3E71D972E2D CRC64;
     MGNCLHRAEL SPSTENSSQL DFEDVWNSSY GVNDSFPDGD YGANLEAAAP CHSCNLLDDS
     ALPFFILTSV LGILASSTVL FMLFRPLFRW QLCPGWPVLA QLAVGSALFS IVVPVLAPGL
     GSTRSSALCS LGYCVWYGSA FAQALLLGCH ASLGHRLGAG QVPGLTLGLT VGIWGVAALL
     TLPVTLASGA SGGLCTLIYS TELKALQATH TVACLAIFVL LPLGLFGAKG LKKALGMGPG
     PWMNILWAWF IFWWPHGVVL GLDFLVRSKL LLLSTCLAQQ ALDLLLNLAE ALAILHCVAT
     PLLLALFCHQ ATRTLLPSLP LPEGWSSHLD TLGSKS
 
 
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