ACKR1_MOUSE
ID ACKR1_MOUSE Reviewed; 334 AA.
AC Q9QUI6; O35970; Q91VB6; Q920X0; Q920X1; Q920X2; Q920X3;
DT 10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2003, sequence version 2.
DT 25-MAY-2022, entry version 135.
DE RecName: Full=Atypical chemokine receptor 1;
DE AltName: Full=Duffy antigen/chemokine receptor;
DE AltName: CD_antigen=CD234;
GN Name=Ackr1; Synonyms=Darc, Dfy, Fy;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX PubMed=9314499; DOI=10.1101/gr.7.9.932;
RA Luo H., Chaudhuri A., Johnson K.R., Neote K., Zbrzezna V., He Y.,
RA Pogo A.O.;
RT "Cloning, characterization, and mapping of a murine promiscuous chemokine
RT receptor gene: homolog of the human Duffy gene.";
RL Genome Res. 7:932-941(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Skeletal muscle;
RA Tournamille C., Colin Y.;
RT "Murine skeletal muscle duffy antigen/receptor for chemokine glycoprotein
RT (DARC).";
RL Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10520743; DOI=10.3109/10425179809072188;
RA Tang T., Owen J.D., Du J., Walker C.L., Richmond A.;
RT "Molecular cloning and characterization of a mouse gene with homology to
RT the Duffy-antigen receptor for chemokines.";
RL DNA Seq. 9:129-143(1998).
RN [4]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BFM/2Msf, BLG2/Msf, C57BL/10SnJ, CAST/EiJ, HMI/Msf, MSM/Msf,
RC NJL/Msf, Pgn2, and SWN/Msf;
RA Liu Y., Kitano T., Koide T., Shiroishi T., Moriwaki K., Saitou N.;
RT "Conspicuous differences among gene genealogies of 21 nuclear genes of five
RT Mus musculus subspecies.";
RL Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Atypical chemokine receptor that controls chemokine levels
CC and localization via high-affinity chemokine binding that is uncoupled
CC from classic ligand-driven signal transduction cascades, resulting
CC instead in chemokine sequestration, degradation, or transcytosis. Also
CC known as interceptor (internalizing receptor) or chemokine-scavenging
CC receptor or chemokine decoy receptor. Has a promiscuous chemokine-
CC binding profile, interacting with inflammatory chemokines of both the
CC CXC and the CC subfamilies but not with homeostatic chemokines. Acts as
CC a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13,
CC CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and
CC TARC. May regulate chemokine bioavailability and, consequently,
CC leukocyte recruitment through two distinct mechanisms: when expressed
CC in endothelial cells, it sustains the abluminal to luminal transcytosis
CC of tissue-derived chemokines and their subsequent presentation to
CC circulating leukocytes; when expressed in erythrocytes, serves as blood
CC reservoir of cognate chemokines but also as a chemokine sink, buffering
CC potential surges in plasma chemokine levels (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Early endosome {ECO:0000250}. Recycling endosome
CC {ECO:0000250}. Membrane; Multi-pass membrane protein.
CC Note=Predominantly localizes to endocytic vesicles, and upon
CC stimulation by the ligand is internalized via caveolae. Once
CC internalized, the ligand dissociates from the receptor, and is targeted
CC to degradation while the receptor is recycled back to the cell membrane
CC (By similarity). {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in liver and brain.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC Atypical chemokine receptor subfamily. {ECO:0000305}.
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DR EMBL; AF016697; AAC53360.1; -; Genomic_DNA.
DR EMBL; AF016584; AAC53354.1; -; mRNA.
DR EMBL; AF109159; AAF14225.1; -; mRNA.
DR EMBL; U88431; AAF08328.1; -; Genomic_DNA.
DR EMBL; AB039074; BAB68598.1; -; Genomic_DNA.
DR EMBL; AB039075; BAB68599.1; -; Genomic_DNA.
DR EMBL; AB039076; BAB68600.1; -; Genomic_DNA.
DR EMBL; AB039077; BAB68601.1; -; Genomic_DNA.
DR EMBL; AB039078; BAB68602.1; -; Genomic_DNA.
DR EMBL; AB039079; BAB68603.1; -; Genomic_DNA.
DR EMBL; AB039080; BAB68604.1; -; Genomic_DNA.
DR EMBL; AB039081; BAB68605.1; -; Genomic_DNA.
DR EMBL; AB039082; BAB68606.1; -; Genomic_DNA.
DR EMBL; BC005583; AAH05583.1; -; mRNA.
DR CCDS; CCDS35789.1; -.
DR RefSeq; NP_034175.2; NM_010045.2.
DR AlphaFoldDB; Q9QUI6; -.
DR SMR; Q9QUI6; -.
DR STRING; 10090.ENSMUSP00000045134; -.
DR GlyGen; Q9QUI6; 4 sites.
DR iPTMnet; Q9QUI6; -.
DR PhosphoSitePlus; Q9QUI6; -.
DR MaxQB; Q9QUI6; -.
DR PaxDb; Q9QUI6; -.
DR PRIDE; Q9QUI6; -.
DR ProteomicsDB; 285541; -.
DR DNASU; 13349; -.
DR GeneID; 13349; -.
DR KEGG; mmu:13349; -.
DR CTD; 2532; -.
DR MGI; MGI:1097689; Ackr1.
DR eggNOG; ENOG502SNW7; Eukaryota.
DR InParanoid; Q9QUI6; -.
DR OrthoDB; 1194550at2759; -.
DR PhylomeDB; Q9QUI6; -.
DR TreeFam; TF105419; -.
DR BioGRID-ORCS; 13349; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Ackr1; mouse.
DR PRO; PR:Q9QUI6; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q9QUI6; protein.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0055037; C:recycling endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0019957; F:C-C chemokine binding; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IMP:MGI.
DR GO; GO:0032642; P:regulation of chemokine production; IMP:MGI.
DR InterPro; IPR005384; Duffy_chemokine_rcpt.
DR PANTHER; PTHR14181; PTHR14181; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Endosome; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..334
FT /note="Atypical chemokine receptor 1"
FT /id="PRO_0000152587"
FT TOPO_DOM 1..61
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 83..93
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..127
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..151
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 152..164
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 186..205
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 227..242
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 264..285
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 286..306
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 307..334
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 16
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 26
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 32
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 285
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 49..274
FT /evidence="ECO:0000250"
FT DISULFID 127..193
FT /evidence="ECO:0000250"
FT VARIANT 10
FT /note="T -> N (in strain: BLG2/Msf, C57BL/10SnJ, HMI/Msf,
FT MSM/Msf, NJL/Msf and SWN/Msf)"
FT VARIANT 56
FT /note="D -> G (in strain: BLG2/Msf, C57BL/10SnJ, HMI/Msf,
FT MSM/Msf, NJL/Msf and SWN/Msf)"
FT VARIANT 61
FT /note="P -> L (in strain: BLG2/Msf)"
FT VARIANT 76
FT /note="S -> G (in strain: BLG2/Msf, C57BL/10SnJ, CAST/Ei,
FT HMI/Msf, MSM/Msf, NJL/Msf and SWN/Msf)"
FT VARIANT 178
FT /note="S -> L (in strain: BLG2/Msf, C57BL/10SnJ, CAST/Ei,
FT HMI/Msf, MSM/Msf, NJL/Msf, pgn2 and SWN/Msf)"
FT VARIANT 188
FT /note="V -> A (in strain: BLG2/Msf, C57BL/10SnJ, CAST/Ei,
FT HMI/Msf, MSM/Msf, NJL/Msf and SWN/Msf)"
FT VARIANT 194
FT /note="T -> A (in strain: BLG2/Msf, C57BL/10SnJ, HMI/Msf,
FT MSM/Msf, NJL/Msf and SWN/Msf)"
FT VARIANT 207
FT /note="T -> M (in strain: C57BL/10SnJ, HMI/Msf, MSM/Msf and
FT SWN/Msf)"
FT VARIANT 221
FT /note="L -> P (in strain: BLG2/Msf, C57BL/10SnJ, HMI/Msf,
FT MSM/Msf, NJL/Msf and SWN/Msf)"
FT VARIANT 256
FT /note="M -> I (in strain: NJL/Msf)"
FT VARIANT 268
FT /note="T -> I (in strain: BLG2/Msf, C57BL/10SnJ, HMI/Msf,
FT MSM/Msf, NJL/Msf and SWN/Msf)"
SQ SEQUENCE 334 AA; 36694 MW; 21AC4B6147D840C8 CRC64;
MGNCLYPVET LSLDKNGTQF TFDSWNYSFE DNYSYELSSD YSLTPAAPCY SCNLLDRSSL
PFFMLTSVLG MLASGSILFA ILRPFFHWQI CPSWPILAEL AVGSALFSIA VPILAPGLHS
AHSTALCNLG YWVWYTSAFA QALLIGCYAC LNPRLNIGQL RGFTLGLSVG LWGAAALSGL
PVALASDVYN GFCTFPSSRD MEALKYTHYA ICFTIFTVLP LTLLAAKGLK IALSKGPGPW
VSVLWIWFIF WWPHGMVLIF DALVRSKTVL LYTCQSQKIL DAMLNVTEAL SMLHCVATPL
LLALFCHQTT RRSLSSLSLP TRQASQMDAL AGKS
