CNGC7_ARATH
ID CNGC7_ARATH Reviewed; 738 AA.
AC Q9S9N5; F4I2R9;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Putative cyclic nucleotide-gated ion channel 7;
DE AltName: Full=Cyclic nucleotide- and calmodulin-regulated ion channel 7;
GN Name=CNGC7; OrderedLocusNames=At1g15990; ORFNames=T24D18.9;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11500563; DOI=10.1104/pp.126.4.1646;
RA Maeser P., Thomine S., Schroeder J.I., Ward J.M., Hirschi K., Sze H.,
RA Talke I.N., Amtmann A., Maathuis F.J.M., Sanders D., Harper J.F.,
RA Tchieu J., Gribskov M., Persans M.W., Salt D.E., Kim S.A., Guerinot M.L.;
RT "Phylogenetic relationships within cation transporter families of
RT Arabidopsis.";
RL Plant Physiol. 126:1646-1667(2001).
CC -!- FUNCTION: Putative cyclic nucleotide-gated ion channel.
CC -!- SUBUNIT: Homotetramer or heterotetramer. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- DOMAIN: The binding of calmodulin to the C-terminus might interfere
CC with cyclic nucleotide binding and thus channel activation.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the cyclic nucleotide-gated cation channel (TC
CC 1.A.1.5) family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC010924; AAF18496.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE29393.2; -; Genomic_DNA.
DR PIR; E86294; E86294.
DR RefSeq; NP_001319014.1; NM_001332197.1.
DR AlphaFoldDB; Q9S9N5; -.
DR STRING; 3702.AT1G15990.1; -.
DR iPTMnet; Q9S9N5; -.
DR PaxDb; Q9S9N5; -.
DR PRIDE; Q9S9N5; -.
DR ProteomicsDB; 220394; -.
DR EnsemblPlants; AT1G15990.1; AT1G15990.1; AT1G15990.
DR GeneID; 838169; -.
DR Gramene; AT1G15990.1; AT1G15990.1; AT1G15990.
DR KEGG; ath:AT1G15990; -.
DR Araport; AT1G15990; -.
DR TAIR; locus:2200502; AT1G15990.
DR eggNOG; KOG0498; Eukaryota.
DR HOGENOM; CLU_013069_3_0_1; -.
DR InParanoid; Q9S9N5; -.
DR OMA; VLGMICM; -.
DR OrthoDB; 281394at2759; -.
DR PhylomeDB; Q9S9N5; -.
DR PRO; PR:Q9S9N5; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9S9N5; baseline and differential.
DR Genevisible; Q9S9N5; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR GO; GO:0090406; C:pollen tube; IDA:TAIR.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.
DR GO; GO:0030553; F:cGMP binding; IEA:UniProtKB-KW.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR GO; GO:0009860; P:pollen tube growth; IGI:TAIR.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 2.60.120.10; -; 1.
DR InterPro; IPR018490; cNMP-bd-like.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR01463; EAGCHANLFMLY.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; SSF51206; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 3: Inferred from homology;
KW Calmodulin-binding; cAMP; cAMP-binding; Cell membrane; cGMP; cGMP-binding;
KW Ion channel; Ion transport; Ligand-gated ion channel; Membrane;
KW Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..738
FT /note="Putative cyclic nucleotide-gated ion channel 7"
FT /id="PRO_0000219335"
FT TOPO_DOM 1..104
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical; Name=H1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 126..139
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=H2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..193
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical; Name=H3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 215..227
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 228..248
FT /note="Helical; Name=H4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 249..268
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical; Name=H5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..395
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 396..416
FT /note="Helical; Name=H6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 417..738
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 638..667
FT /note="IQ"
FT REGION 618..633
FT /note="Calmodulin-binding"
FT /evidence="ECO:0000250"
FT REGION 671..693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 715..738
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 502..632
FT /ligand="a nucleoside 3',5'-cyclic phosphate"
FT /ligand_id="ChEBI:CHEBI:58464"
FT BINDING 573
FT /ligand="a nucleoside 3',5'-cyclic phosphate"
FT /ligand_id="ChEBI:CHEBI:58464"
FT /evidence="ECO:0000250"
SQ SEQUENCE 738 AA; 84634 MW; 369AB538E25959BF CRC64;
MYKSQYISGQ REKFVRLDDI DSSSSPATGM MMQRNCFGFN LKNRGGEKKK ASKSFREGVK
KIRSEGLITI GKSVTRAVFP EDLRITEKKI FDPQDKTLLV WNRLFVISCI LAVSVDPLFF
YLPIVDNSGS SCIGIDTKLA VTTTTLRTIV DVFYLTRMAL QFRTAYIAPS SRVFGRGELV
IDPAKIAERY LTRYFVVDFL AVLPLPQIAV WKFLHGSKGS DVLPTKTALL NIVIVQYIPR
FVRFIPLTSE LKKTAGAFAE GAWAGAAYYL LWYMLASHIT GAFWYMLSVE RNDTCWRFAC
KVQPDPRLCV QILYCGTKFV SSGETEWIKT VPELLKSNCS AKADDSKFNY GIYGQAISSG
IVSSTTFFSK FCYCLWWGLQ NLSTLGQGLQ TSTFPGEVLF SIAIAIAGLL LFALLIGNMQ
TYLQSLTVRL EEMRIKRRDS EQWMHHRSLP QNLRERVRRY DQYKWLETRG VDEENIVQSL
PKDLRRDIKR HLCLNLVRRV PLFANMDERL LDAICERLKP SLFTESTYIV REGDPVNEMM
FIIRGRLESV TTDGGRSGFF NRGLLKEGDF CGEELLTWAL DPKAGSNLPS STRTVKALTE
VEAFALEAEE LKFVASQFRR LHSRQVQQTF RFYSQQWRTW ASCFIQAAWR RYSRRKNAEL
RRIEEKEEEL GYEDEYDDES DKRPMVITRS ESSSRLRSTI FASRFAANAL KGHRLRSSES
SKTLINLQKP PEPDFDAE
