ID   CNG_ICTPU               Reviewed;         682 AA.
AC   P55934;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Cyclic nucleotide-gated cation channel;
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   TISSUE=Olfactory neuroepithelium;
RX   PubMed=1370374; DOI=10.1016/0896-6273(92)90107-o;
RA   Goulding E.H., Ngai J., Kramer R.H., Colicos S., Axel R., Siegelbaum S.A.,
RA   Chess A.;
RT   "Molecular cloning and single-channel properties of the cyclic nucleotide-
RT   gated channel from catfish olfactory neurons.";
RL   Neuron 8:45-58(1992).
CC   -!- FUNCTION: This cyclic nucleotide-gated channel is activated equally
CC       well by both cAMP and cGMP.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Olfactory neurons.
CC   -!- SIMILARITY: Belongs to the cyclic nucleotide-gated cation channel (TC
CC       1.A.1.5) family. {ECO:0000305}.
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DR   EMBL; M83111; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   PIR; JH0560; JH0560.
DR   AlphaFoldDB; P55934; -.
DR   SMR; P55934; -.
DR   TCDB; 1.A.1.5.1; the voltage-gated ion channel (vic) superfamily.
DR   Proteomes; UP000221080; Genome assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.
DR   GO; GO:0030553; F:cGMP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0007608; P:sensory perception of smell; IEA:UniProtKB-KW.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR032406; CLZ_dom.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR018488; cNMP-bd_CS.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF16526; CLZ; 1.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   PROSITE; PS00888; CNMP_BINDING_1; 1.
DR   PROSITE; PS00889; CNMP_BINDING_2; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   2: Evidence at transcript level;
KW   cAMP; cAMP-binding; cGMP; cGMP-binding; Ion channel; Ion transport;
KW   Ligand-gated ion channel; Membrane; Nucleotide-binding; Olfaction;
KW   Sensory transduction; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..682
FT                   /note="Cyclic nucleotide-gated cation channel"
FT                   /id="PRO_0000219326"
FT   TOPO_DOM        1..136
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        137..157
FT                   /note="Helical; Name=H1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        158..169
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        170..190
FT                   /note="Helical; Name=H2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        191..218
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        219..239
FT                   /note="Helical; Name=H3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        240..272
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..293
FT                   /note="Helical; Name=H4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        294..311
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        312..332
FT                   /note="Helical; Name=H5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        333..343
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        344..364
FT                   /note="Helical; Name=H6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        365..682
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          649..682
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        14..41
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        650..682
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         455..577
FT                   /ligand="3',5'-cyclic AMP"
FT                   /ligand_id="ChEBI:CHEBI:58165"
FT                   /evidence="ECO:0000250"
FT   BINDING         514
FT                   /ligand="3',5'-cyclic AMP"
FT                   /ligand_id="ChEBI:CHEBI:58165"
FT                   /evidence="ECO:0000255"
FT   BINDING         529
FT                   /ligand="3',5'-cyclic AMP"
FT                   /ligand_id="ChEBI:CHEBI:58165"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   682 AA;  78020 MW;  2C78597DC2C74F75 CRC64;
     MTGQAALERS VSSHRLSVRS RLEGEAERAE SAISRTDGDD DTCSELQRVT ALELPSAEML
     EAFTQRRPLA RLVNLVLSLR EWAHKSLVET EQRPDSFLER FRGPQAANDQ SAAPADAPKK
     TFKERWEGFV VSQSDDIYYY WLFFIALASL YNWIMLVARA CFDQLQDENF FLWVGLDYLC
     DVIYILDTCI RLRTGYLEQG LLVKDLAKLR DNYIRTLQFK LDFLSILPTE LLFFVTGYVP
     QLRFNRLLRF SRMFEFFDRT ETRTNYPNAF RICNLILYIL VIIHWNACIY YAISKALGLS
     SDTWVYSGQN KTLSFCYVYC FYWSTLTLTT IGEMPPPVKD EEYVFVVFDF LVGVLIFATI
     VGNVGSMIAN MNATRAEFQT RIDAIKHYMH FRKVNRTLET RVIKWFDYLW TNKKTVDEQE
     VLKNLPDKLR AEIAINVHLD TLKKVRIFQD CEAGLLVELV LKLRPQVYSP GDYICRKGDI
     GKEMYIIKEG QLAVVADDGV TQFALLTAGG CFGEISILNI QGSKMGNRRT ANIRSIGYSD
     LFCLSKDDLM EAVAEYPDAQ KVLEERGREI LRKQGLLDES VAAGGLGVID TEEKVERLDA
     SLDILQTRFA RLLGEFTSTQ RRLKQRITAL ERQLCHTGLG LLSDNEAEGE HAGVPTHTHA
     DIHAQPETHT RTSAETNSEE ET