ID   CNIH1_BOVIN             Reviewed;         144 AA.
AC   Q5BIN6; Q0P5M1;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Protein cornichon homolog 1;
DE            Short=CNIH-1;
DE   AltName: Full=Cornichon family AMPA receptor auxiliary protein 1;
DE   AltName: Full=Protein cornichon homolog;
GN   Name=CNIH1; Synonyms=CNIH;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hippocampus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the selective transport and maturation of TGF-
CC       alpha family proteins. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with AREG immature precursor and with immature TGFA,
CC       i.e. with a prosegment and lacking full N-glycosylation, but not with
CC       the fully N-glycosylated form. In the Golgi apparatus, may form a
CC       complex with GORASP55 and transmembrane TGFA (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
CC       membrane protein. Golgi apparatus membrane. Note=Located primarily in
CC       the ER; may cycle between the ER and the Golgi apparatus.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cornichon family. {ECO:0000305}.
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DR   EMBL; BT021188; AAX31370.1; -; mRNA.
DR   EMBL; BC119865; AAI19866.1; -; mRNA.
DR   RefSeq; NP_001029911.1; NM_001034739.2.
DR   AlphaFoldDB; Q5BIN6; -.
DR   SMR; Q5BIN6; -.
DR   STRING; 9913.ENSBTAP00000041260; -.
DR   Ensembl; ENSBTAT00000025975; ENSBTAP00000025975; ENSBTAG00000019500.
DR   GeneID; 613575; -.
DR   KEGG; bta:613575; -.
DR   CTD; 10175; -.
DR   VEuPathDB; HostDB:ENSBTAG00000019500; -.
DR   VGNC; VGNC:27502; CNIH1.
DR   GeneTree; ENSGT00950000182834; -.
DR   HOGENOM; CLU_112942_1_0_1; -.
DR   InParanoid; Q5BIN6; -.
DR   OMA; WIAFLLN; -.
DR   OrthoDB; 1602458at2759; -.
DR   Reactome; R-BTA-204005; COPII-mediated vesicle transport.
DR   Reactome; R-BTA-5694530; Cargo concentration in the ER.
DR   Proteomes; UP000009136; Chromosome 10.
DR   Bgee; ENSBTAG00000019500; Expressed in spermatocyte and 108 other tissues.
DR   ExpressionAtlas; Q5BIN6; baseline and differential.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR   InterPro; IPR003377; Cornichon.
DR   InterPro; IPR033466; Cornichon_conserved.
DR   Pfam; PF03311; Cornichon; 1.
DR   SMART; SM01398; Cornichon; 1.
DR   PROSITE; PS01340; CORNICHON; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..144
FT                   /note="Protein cornichon homolog 1"
FT                   /id="PRO_0000122221"
FT   TOPO_DOM        1..10
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        32..56
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        78..122
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        123..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        144
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   144 AA;  16699 MW;  59BD114D24C455CD CRC64;
     MAFTFAAFCY MLALLLTAAL IFFAIWHIIA FDELKTDYKN PIDQCNTLNP LVLPEYLIHA
     FFCVMFLCAA EWLTLGLNMP LLAYHIWRYM SRPVMSGPGL YDPTTIMNAD ILAYCQKEGW
     CKLAFYLLAF FYYLYGMIYV LVSS