CNIH1_ORYSJ
ID CNIH1_ORYSJ Reviewed; 135 AA.
AC Q0DET3; A0A0P0WS32; A3B864;
DT 03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT 03-AUG-2022, sequence version 2.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=Protein cornichon homolog 1 {ECO:0000305};
DE Short=OsCNIH {ECO:0000303|PubMed:25750424};
GN Name=CNIH1 {ECO:0000303|PubMed:25750424};
GN OrderedLocusNames=Os06g0136500 {ECO:0000312|EMBL:BAS96035.1},
GN LOC_Os06g04500 {ECO:0000305};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [5]
RP FUNCTION, INTERACTION WITH HKT1;3, AND SUBCELLULAR LOCATION.
RX PubMed=25750424; DOI=10.1093/jxb/erv069;
RA Rosas-Santiago P., Lagunas-Gomez D., Barkla B.J., Vera-Estrella R.,
RA Lalonde S., Jones A., Frommer W.B., Zimmermannova O., Sychrova H.,
RA Pantoja O.;
RT "Identification of rice cornichon as a possible cargo receptor for the
RT Golgi-localized sodium transporter OsHKT1;3.";
RL J. Exp. Bot. 66:2733-2748(2015).
RN [6]
RP FUNCTION, INTERACTION WITH HKT1;3, SUBCELLULAR LOCATION, AND MUTAGENESIS OF
RP 132-GLU--GLU-135.
RX PubMed=28723420; DOI=10.1016/j.bbamcr.2017.07.004;
RA Rosas-Santiago P., Lagunas-Gomez D., Yanez-Dominguez C., Vera-Estrella R.,
RA Zimmermannova O., Sychrova H., Pantoja O.;
RT "Plant and yeast cornichon possess a conserved acidic motif required for
RT correct targeting of plasma membrane cargos.";
RL Biochim. Biophys. Acta 1864:1809-1818(2017).
CC -!- FUNCTION: Acts as cargo receptor necessary for the transportation of
CC the cation transporter HKT1;3 and possibly other secretory proteins
CC from the endoplasmic reticulum (ER) in COPII-coated vesicles targeted
CC to the Golgi apparatus. {ECO:0000269|PubMed:25750424,
CC ECO:0000269|PubMed:28723420}.
CC -!- SUBUNIT: Interacts with HKT1;3. {ECO:0000269|PubMed:25750424,
CC ECO:0000269|PubMed:28723420}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:25750424, ECO:0000269|PubMed:28723420}; Multi-pass
CC membrane protein {ECO:0000255}. Golgi apparatus membrane
CC {ECO:0000269|PubMed:25750424, ECO:0000269|PubMed:28723420}; Multi-pass
CC membrane protein {ECO:0000255}. Note=Located primarily in the
CC endoplasmic reticulum (ER); may cycle between the ER and the Golgi
CC apparatus. {ECO:0000305|PubMed:25750424}.
CC -!- SIMILARITY: Belongs to the cornichon family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAF18640.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAS96035.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=EAZ35753.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AP008212; BAF18640.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP014962; BAS96035.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CM000143; EAZ35753.1; ALT_SEQ; Genomic_DNA.
DR SMR; Q0DET3; -.
DR STRING; 4530.OS06T0136500-01; -.
DR EnsemblPlants; Os06t0136500-01; Os06t0136500-01; Os06g0136500.
DR Gramene; Os06t0136500-01; Os06t0136500-01; Os06g0136500.
DR eggNOG; KOG2729; Eukaryota.
DR HOGENOM; CLU_112942_2_0_1; -.
DR OMA; LECDCIN; -.
DR Proteomes; UP000000763; Chromosome 6.
DR Proteomes; UP000007752; Chromosome 6.
DR Proteomes; UP000059680; Chromosome 6.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR InterPro; IPR003377; Cornichon.
DR Pfam; PF03311; Cornichon; 1.
DR SMART; SM01398; Cornichon; 1.
PE 1: Evidence at protein level;
KW Endoplasmic reticulum; Golgi apparatus; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..135
FT /note="Protein cornichon homolog 1"
FT /id="PRO_0000455963"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 111..131
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MUTAGEN 132..135
FT /note="Missing: Does not modify subcellular localization,
FT but reduces interaction with HKT1;3 and CNIH1 function as
FT cargo receptor."
FT /evidence="ECO:0000269|PubMed:28723420"
SQ SEQUENCE 135 AA; 15998 MW; 9F59A937E8485DA3 CRC64;
MVFVWLTAFF LVVALIVLVI YQLMCLADLE FDYINPFDSS SRINKVVIPE FVLQAALSVL
FLLSGHWAMF LLSAPMVYYN YTLYQRRQHL VDVTEIFNHL GREKKRRLFK IVGLIILLFL
SLFWMIWTVL LEEDE
