ID   CNIH2_DANRE             Reviewed;         160 AA.
AC   Q5BL21;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Protein cornichon homolog 2;
DE            Short=CNIH-2;
DE   AltName: Full=Cornichon family AMPA receptor auxiliary protein 2;
GN   Name=cnih2; ORFNames=zgc:101874;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Larva;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates the trafficking and gating properties of AMPA-
CC       selective glutamate receptors (AMPARs). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cornichon family. {ECO:0000305}.
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DR   EMBL; BC090830; AAH90830.1; -; mRNA.
DR   RefSeq; NP_001013542.1; NM_001013524.1.
DR   RefSeq; XP_005155427.1; XM_005155370.3.
DR   AlphaFoldDB; Q5BL21; -.
DR   SMR; Q5BL21; -.
DR   STRING; 7955.ENSDARP00000115028; -.
DR   PaxDb; Q5BL21; -.
DR   Ensembl; ENSDART00000041841; ENSDARP00000041840; ENSDARG00000043662.
DR   Ensembl; ENSDART00000143451; ENSDARP00000115028; ENSDARG00000043662.
DR   GeneID; 541397; -.
DR   KEGG; dre:541397; -.
DR   CTD; 254263; -.
DR   ZFIN; ZDB-GENE-050320-96; cnih2.
DR   eggNOG; KOG2729; Eukaryota.
DR   GeneTree; ENSGT00950000182834; -.
DR   HOGENOM; CLU_112942_1_0_1; -.
DR   InParanoid; Q5BL21; -.
DR   OMA; DDFINPI; -.
DR   OrthoDB; 1602458at2759; -.
DR   PhylomeDB; Q5BL21; -.
DR   TreeFam; TF300083; -.
DR   Reactome; R-DRE-204005; COPII-mediated vesicle transport.
DR   Reactome; R-DRE-5694530; Cargo concentration in the ER.
DR   PRO; PR:Q5BL21; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 10.
DR   Bgee; ENSDARG00000043662; Expressed in brain and 9 other tissues.
DR   GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045202; C:synapse; IBA:GO_Central.
DR   GO; GO:2000311; P:regulation of AMPA receptor activity; IBA:GO_Central.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   InterPro; IPR003377; Cornichon.
DR   InterPro; IPR033466; Cornichon_conserved.
DR   Pfam; PF03311; Cornichon; 2.
DR   SMART; SM01398; Cornichon; 1.
DR   PROSITE; PS01340; CORNICHON; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..160
FT                   /note="Protein cornichon homolog 2"
FT                   /id="PRO_0000408975"
FT   TOPO_DOM        1..10
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        32..72
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        94..138
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        160
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   160 AA;  18912 MW;  394EC2BCAFD137DD CRC64;
     MAFTFAAFCY MLTLVLCAAL IFFVIWQIIA FDELRTDFKN PIDQSNPTRA RERILNIERI
     CNLLRRLVVP EYSIHGLFCL MFMCAGEWVT LGLNIPLLLY HLWRFFHRPA DGSEVMYDPV
     SVMNADILNY CQKESWCKLG FYLLSFFYYL YSMVYALVSF