ID   CNIH2_XENLA             Reviewed;         162 AA.
AC   Q68EY2;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Protein cornichon homolog 2;
DE            Short=CNIH-2;
DE   AltName: Full=Cornichon family AMPA receptor auxiliary protein 2;
GN   Name=cnih2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates the trafficking and gating properties of AMPA-
CC       selective glutamate receptors (AMPARs). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cornichon family. {ECO:0000305}.
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DR   EMBL; BC080068; AAH80068.1; -; mRNA.
DR   EMBL; BC092335; AAH92335.1; -; mRNA.
DR   RefSeq; NP_001087528.1; NM_001094059.1.
DR   AlphaFoldDB; Q68EY2; -.
DR   SMR; Q68EY2; -.
DR   DNASU; 447352; -.
DR   GeneID; 447352; -.
DR   KEGG; xla:447352; -.
DR   CTD; 447352; -.
DR   Xenbase; XB-GENE-952880; cnih2.S.
DR   OMA; DDFINPI; -.
DR   OrthoDB; 1602458at2759; -.
DR   Proteomes; UP000186698; Chromosome 4S.
DR   Bgee; 447352; Expressed in brain and 3 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   InterPro; IPR003377; Cornichon.
DR   Pfam; PF03311; Cornichon; 1.
DR   SMART; SM01398; Cornichon; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..162
FT                   /note="Protein cornichon homolog 2"
FT                   /id="PRO_0000408976"
FT   TOPO_DOM        1..10
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        32..72
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        94..138
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        162
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   162 AA;  19123 MW;  096C56081949C05F CRC64;
     MAFTFAAFCY MLTLVLCASL IFFIIWHIIA FDDLRTDFKD PIEQGNPSRA RERIKNVERV
     CCLLRKLVVP EYCIHGLFCL MFMCAAEWVT LGLNIPLLFY HLWRYFHRPA DGSEVMFDPV
     SIMNVDILNY CQKEAWCKLA FYLLSFFYYL YRVGATVRYV SA