ID   CNIH2_XENTR             Reviewed;         162 AA.
AC   Q0VFK3;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Protein cornichon homolog 2;
DE            Short=CNIH-2;
DE   AltName: Full=Cornichon family AMPA receptor auxiliary protein 2;
GN   Name=cnih2;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates the trafficking and gating properties of AMPA-
CC       selective glutamate receptors (AMPARs). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cornichon family. {ECO:0000305}.
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DR   EMBL; BC118797; AAI18798.1; -; mRNA.
DR   RefSeq; NP_001072219.1; NM_001078751.1.
DR   AlphaFoldDB; Q0VFK3; -.
DR   SMR; Q0VFK3; -.
DR   STRING; 8364.ENSXETP00000016261; -.
DR   PaxDb; Q0VFK3; -.
DR   DNASU; 779666; -.
DR   Ensembl; ENSXETT00000018450; ENSXETP00000018450; ENSXETG00000008423.
DR   GeneID; 779666; -.
DR   KEGG; xtr:779666; -.
DR   CTD; 254263; -.
DR   Xenbase; XB-GENE-952875; cnih2.
DR   eggNOG; KOG2729; Eukaryota.
DR   HOGENOM; CLU_112942_1_0_1; -.
DR   InParanoid; Q0VFK3; -.
DR   OMA; ISIMNAD; -.
DR   OrthoDB; 1602458at2759; -.
DR   PhylomeDB; Q0VFK3; -.
DR   TreeFam; TF300083; -.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000008423; Expressed in brain and 1 other tissue.
DR   GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045202; C:synapse; IBA:GO_Central.
DR   GO; GO:2000311; P:regulation of AMPA receptor activity; IBA:GO_Central.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   InterPro; IPR003377; Cornichon.
DR   InterPro; IPR033466; Cornichon_conserved.
DR   Pfam; PF03311; Cornichon; 2.
DR   SMART; SM01398; Cornichon; 1.
DR   PROSITE; PS01340; CORNICHON; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..162
FT                   /note="Protein cornichon homolog 2"
FT                   /id="PRO_0000408977"
FT   TOPO_DOM        1..10
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        32..72
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        94..138
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        162
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   162 AA;  19136 MW;  C512C9125BEB59DD CRC64;
     MAFTFAAFCY MLTLVLCASL IFFIIWHIIA FDELRTDFKN PIEQGNPSRA RERVKNVERI
     CCLLRKLVVP EYCIHGLFCL MFMCAAEWVT LGLNIPLLFY HLWRYFHRPA DGSEVMFDPV
     SIMNVDILNY CQKEAWCKLA FYLLSFFYYL YRVGATVRYV SA