CNIH3_HUMAN
ID CNIH3_HUMAN Reviewed; 160 AA.
AC Q8TBE1;
DT 17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Protein cornichon homolog 3;
DE Short=CNIH-3;
DE AltName: Full=Cornichon family AMPA receptor auxiliary protein 3;
GN Name=CNIH3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION.
RX PubMed=20805473; DOI=10.1073/pnas.1011706107;
RA Shi Y., Suh Y.H., Milstein A.D., Isozaki K., Schmid S.M., Roche K.W.,
RA Nicoll R.A.;
RT "Functional comparison of the effects of TARPs and cornichons on AMPA
RT receptor trafficking and gating.";
RL Proc. Natl. Acad. Sci. U.S.A. 107:16315-16319(2010).
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=23103966; DOI=10.1097/wnr.0b013e32835ad229;
RA Drummond J.B., Simmons M., Haroutunian V., Meador-Woodruff J.H.;
RT "Upregulation of cornichon transcripts in the dorsolateral prefrontal
RT cortex in schizophrenia.";
RL NeuroReport 23:1031-1034(2012).
CC -!- FUNCTION: Regulates the trafficking and gating properties of AMPA-
CC selective glutamate receptors (AMPARs). Promotes their targeting to the
CC cell membrane and synapses and modulates their gating properties by
CC regulating their rates of activation, deactivation and desensitization.
CC {ECO:0000269|PubMed:20805473}.
CC -!- SUBUNIT: Acts as an auxiliary subunit for AMPA-selective glutamate
CC receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4,
CC CNIH2, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8 (By
CC similarity). {ECO:0000250}.
CC -!- INTERACTION:
CC Q8TBE1; Q13520: AQP6; NbExp=3; IntAct=EBI-12208021, EBI-13059134;
CC Q8TBE1; Q13323: BIK; NbExp=3; IntAct=EBI-12208021, EBI-700794;
CC Q8TBE1; P11912: CD79A; NbExp=3; IntAct=EBI-12208021, EBI-7797864;
CC Q8TBE1; P40198: CEACAM3; NbExp=3; IntAct=EBI-12208021, EBI-12851752;
CC Q8TBE1; P56880: CLDN20; NbExp=3; IntAct=EBI-12208021, EBI-23801559;
CC Q8TBE1; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-12208021, EBI-781551;
CC Q8TBE1; Q96KR6: FAM210B; NbExp=3; IntAct=EBI-12208021, EBI-18938272;
CC Q8TBE1; Q8TBE3: FNDC9; NbExp=3; IntAct=EBI-12208021, EBI-12142257;
CC Q8TBE1; Q8TED1: GPX8; NbExp=3; IntAct=EBI-12208021, EBI-11721746;
CC Q8TBE1; O15554: KCNN4; NbExp=3; IntAct=EBI-12208021, EBI-2924473;
CC Q8TBE1; A8MZ59: LEUTX; NbExp=3; IntAct=EBI-12208021, EBI-17490413;
CC Q8TBE1; Q8N386: LRRC25; NbExp=3; IntAct=EBI-12208021, EBI-11304917;
CC Q8TBE1; O14524-2: NEMP1; NbExp=3; IntAct=EBI-12208021, EBI-10969203;
CC Q8TBE1; Q2M2E3: ODF4; NbExp=3; IntAct=EBI-12208021, EBI-12382569;
CC Q8TBE1; Q96CV9: OPTN; NbExp=3; IntAct=EBI-12208021, EBI-748974;
CC Q8TBE1; Q8IV08: PLD3; NbExp=3; IntAct=EBI-12208021, EBI-2689908;
CC Q8TBE1; Q9BZL3: SMIM3; NbExp=5; IntAct=EBI-12208021, EBI-741850;
CC Q8TBE1; Q99523: SORT1; NbExp=3; IntAct=EBI-12208021, EBI-1057058;
CC Q8TBE1; P27105: STOM; NbExp=3; IntAct=EBI-12208021, EBI-1211440;
CC Q8TBE1; Q96L08: SUSD3; NbExp=3; IntAct=EBI-12208021, EBI-18194029;
CC Q8TBE1; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-12208021, EBI-8638294;
CC Q8TBE1; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-12208021, EBI-10982110;
CC Q8TBE1; Q4KMG9: TMEM52B; NbExp=3; IntAct=EBI-12208021, EBI-18178701;
CC Q8TBE1; Q96HE8: TMEM80; NbExp=3; IntAct=EBI-12208021, EBI-11742770;
CC Q8TBE1; O15393-2: TMPRSS2; NbExp=3; IntAct=EBI-12208021, EBI-12345267;
CC Q8TBE1; Q9H7M9: VSIR; NbExp=3; IntAct=EBI-12208021, EBI-744988;
CC -!- SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}. Note=Also localizes to the cell
CC membrane of extrasynaptic sites (dendritic shafts, spines of pyramidal
CC cells). {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expression is up-regulated in dorsolateral
CC prefrontal cortex of patients with schizophrenia (postmortem brain
CC study). {ECO:0000269|PubMed:23103966}.
CC -!- SIMILARITY: Belongs to the cornichon family. {ECO:0000305}.
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DR EMBL; AK096312; BAC04760.1; -; mRNA.
DR EMBL; AC096537; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL596330; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC022780; AAH22780.1; -; mRNA.
DR CCDS; CCDS1544.1; -.
DR RefSeq; NP_689708.1; NM_152495.1.
DR AlphaFoldDB; Q8TBE1; -.
DR SMR; Q8TBE1; -.
DR BioGRID; 127193; 29.
DR IntAct; Q8TBE1; 26.
DR STRING; 9606.ENSP00000272133; -.
DR TCDB; 8.A.61.1.10; the endoplasmic reticulum-derived vesicle protein, erv14 (erv14) family.
DR BioMuta; CNIH3; -.
DR DMDM; 27805431; -.
DR jPOST; Q8TBE1; -.
DR MassIVE; Q8TBE1; -.
DR PaxDb; Q8TBE1; -.
DR PeptideAtlas; Q8TBE1; -.
DR PRIDE; Q8TBE1; -.
DR ProteomicsDB; 73999; -.
DR Antibodypedia; 34640; 126 antibodies from 21 providers.
DR DNASU; 149111; -.
DR Ensembl; ENST00000272133.4; ENSP00000272133.3; ENSG00000143786.8.
DR GeneID; 149111; -.
DR KEGG; hsa:149111; -.
DR MANE-Select; ENST00000272133.4; ENSP00000272133.3; NM_152495.2; NP_689708.1.
DR UCSC; uc001hos.2; human.
DR CTD; 149111; -.
DR DisGeNET; 149111; -.
DR GeneCards; CNIH3; -.
DR HGNC; HGNC:26802; CNIH3.
DR HPA; ENSG00000143786; Group enriched (brain, pancreas).
DR neXtProt; NX_Q8TBE1; -.
DR OpenTargets; ENSG00000143786; -.
DR PharmGKB; PA134929862; -.
DR VEuPathDB; HostDB:ENSG00000143786; -.
DR eggNOG; KOG2729; Eukaryota.
DR GeneTree; ENSGT00950000182834; -.
DR HOGENOM; CLU_112942_1_0_1; -.
DR InParanoid; Q8TBE1; -.
DR OMA; QREAWCK; -.
DR OrthoDB; 1602458at2759; -.
DR PhylomeDB; Q8TBE1; -.
DR TreeFam; TF300083; -.
DR PathwayCommons; Q8TBE1; -.
DR Reactome; R-HSA-204005; COPII-mediated vesicle transport.
DR Reactome; R-HSA-5694530; Cargo concentration in the ER.
DR SignaLink; Q8TBE1; -.
DR BioGRID-ORCS; 149111; 13 hits in 1069 CRISPR screens.
DR ChiTaRS; CNIH3; human.
DR GenomeRNAi; 149111; -.
DR Pharos; Q8TBE1; Tbio.
DR PRO; PR:Q8TBE1; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8TBE1; protein.
DR Bgee; ENSG00000143786; Expressed in cortical plate and 128 other tissues.
DR Genevisible; Q8TBE1; HS.
DR GO; GO:0032281; C:AMPA glutamate receptor complex; ISS:UniProtKB.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0043198; C:dendritic shaft; ISS:UniProtKB.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
DR GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; TAS:Reactome.
DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome.
DR GO; GO:0045211; C:postsynaptic membrane; ISS:UniProtKB.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:2000311; P:regulation of AMPA receptor activity; IDA:UniProtKB.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR InterPro; IPR003377; Cornichon.
DR InterPro; IPR033466; Cornichon_conserved.
DR Pfam; PF03311; Cornichon; 2.
DR SMART; SM01398; Cornichon; 1.
DR PROSITE; PS01340; CORNICHON; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Postsynaptic cell membrane; Reference proteome;
KW Synapse; Transmembrane; Transmembrane helix.
FT CHAIN 1..160
FT /note="Protein cornichon homolog 3"
FT /id="PRO_0000122228"
FT TOPO_DOM 1..10
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 32..72
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 94..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160
FT /note="Lumenal"
FT /evidence="ECO:0000255"
SQ SEQUENCE 160 AA; 18976 MW; CF7E8645A9587504 CRC64;
MAFTFAAFCY MLSLVLCAAL IFFAIWHIIA FDELRTDFKS PIDQCNPVHA RERLRNIERI
CFLLRKLVLP EYSIHSLFCI MFLCAQEWLT LGLNVPLLFY HFWRYFHCPA DSSELAYDPP
VVMNADTLSY CQKEAWCKLA FYLLSFFYYL YCMIYTLVSS
