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CNIH3_MOUSE
ID   CNIH3_MOUSE             Reviewed;         160 AA.
AC   Q6ZWS4; Q14BS0;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Protein cornichon homolog 3;
DE            Short=CNIH-3;
DE   AltName: Full=Cornichon family AMPA receptor auxiliary protein 3;
GN   Name=Cnih3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Diencephalon;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Regulates the trafficking and gating properties of AMPA-
CC       selective glutamate receptors (AMPARs). Promotes their targeting to the
CC       cell membrane and synapses and modulates their gating properties by
CC       regulating their rates of activation, deactivation and desensitization
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Acts as an auxiliary subunit for AMPA-selective glutamate
CC       receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4,
CC       CNIH2, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8 (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}. Note=Also localizes to the cell
CC       membrane of extrasynaptic sites (dendritic shafts, spines of pyramidal
CC       cells). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cornichon family. {ECO:0000305}.
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DR   EMBL; AK033911; BAC28511.1; -; mRNA.
DR   EMBL; BC115640; AAI15641.1; -; mRNA.
DR   EMBL; BC115641; AAI15642.1; -; mRNA.
DR   CCDS; CCDS48470.1; -.
DR   RefSeq; NP_001153683.1; NM_001160211.1.
DR   RefSeq; NP_001153684.1; NM_001160212.1.
DR   RefSeq; NP_082684.1; NM_028408.3.
DR   PDB; 6PEQ; EM; 2.97 A; E/F/G/H=1-160.
DR   PDB; 6UCB; EM; 3.28 A; E/F/G/H=1-160.
DR   PDB; 6UD4; EM; 3.30 A; E/F/G/H=1-160.
DR   PDB; 6UD8; EM; 3.20 A; E/F/G/H=1-160.
DR   PDBsum; 6PEQ; -.
DR   PDBsum; 6UCB; -.
DR   PDBsum; 6UD4; -.
DR   PDBsum; 6UD8; -.
DR   AlphaFoldDB; Q6ZWS4; -.
DR   SMR; Q6ZWS4; -.
DR   SwissPalm; Q6ZWS4; -.
DR   PRIDE; Q6ZWS4; -.
DR   ProteomicsDB; 283450; -.
DR   Antibodypedia; 34640; 126 antibodies from 21 providers.
DR   DNASU; 72978; -.
DR   Ensembl; ENSMUST00000027795; ENSMUSP00000027795; ENSMUSG00000026514.
DR   GeneID; 72978; -.
DR   KEGG; mmu:72978; -.
DR   UCSC; uc007dxi.2; mouse.
DR   CTD; 149111; -.
DR   MGI; MGI:1920228; Cnih3.
DR   VEuPathDB; HostDB:ENSMUSG00000026514; -.
DR   GeneTree; ENSGT00950000182834; -.
DR   HOGENOM; CLU_112942_1_0_1; -.
DR   InParanoid; Q6ZWS4; -.
DR   OMA; QREAWCK; -.
DR   OrthoDB; 1602458at2759; -.
DR   Reactome; R-MMU-204005; COPII-mediated vesicle transport.
DR   Reactome; R-MMU-5694530; Cargo concentration in the ER.
DR   BioGRID-ORCS; 72978; 0 hits in 75 CRISPR screens.
DR   PRO; PR:Q6ZWS4; -.
DR   Proteomes; UP000000589; Chromosome 1.
DR   RNAct; Q6ZWS4; protein.
DR   Bgee; ENSMUSG00000026514; Expressed in cortical plate and 59 other tissues.
DR   ExpressionAtlas; Q6ZWS4; baseline and differential.
DR   Genevisible; Q6ZWS4; MM.
DR   GO; GO:0032281; C:AMPA glutamate receptor complex; ISS:UniProtKB.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR   GO; GO:0043198; C:dendritic shaft; ISS:UniProtKB.
DR   GO; GO:0098978; C:glutamatergic synapse; IDA:SynGO.
DR   GO; GO:0045211; C:postsynaptic membrane; ISS:UniProtKB.
DR   GO; GO:0045202; C:synapse; IBA:GO_Central.
DR   GO; GO:0016247; F:channel regulator activity; ISO:MGI.
DR   GO; GO:0051668; P:localization within membrane; ISO:MGI.
DR   GO; GO:0099645; P:neurotransmitter receptor localization to postsynaptic specialization membrane; IDA:SynGO.
DR   GO; GO:2000311; P:regulation of AMPA receptor activity; ISS:UniProtKB.
DR   GO; GO:0042391; P:regulation of membrane potential; ISO:MGI.
DR   GO; GO:0035249; P:synaptic transmission, glutamatergic; ISO:MGI.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   InterPro; IPR003377; Cornichon.
DR   InterPro; IPR033466; Cornichon_conserved.
DR   Pfam; PF03311; Cornichon; 2.
DR   SMART; SM01398; Cornichon; 1.
DR   PROSITE; PS01340; CORNICHON; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell membrane; Membrane; Postsynaptic cell membrane;
KW   Reference proteome; Synapse; Transmembrane; Transmembrane helix.
FT   CHAIN           1..160
FT                   /note="Protein cornichon homolog 3"
FT                   /id="PRO_0000122229"
FT   TOPO_DOM        1..10
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        32..72
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        94..138
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        160
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   HELIX           6..34
FT                   /evidence="ECO:0007829|PDB:6PEQ"
FT   HELIX           51..66
FT                   /evidence="ECO:0007829|PDB:6PEQ"
FT   HELIX           69..84
FT                   /evidence="ECO:0007829|PDB:6PEQ"
FT   HELIX           88..106
FT                   /evidence="ECO:0007829|PDB:6PEQ"
FT   HELIX           128..157
FT                   /evidence="ECO:0007829|PDB:6PEQ"
SQ   SEQUENCE   160 AA;  18976 MW;  CF7E8645A9587504 CRC64;
     MAFTFAAFCY MLSLVLCAAL IFFAIWHIIA FDELRTDFKS PIDQCNPVHA RERLRNIERI
     CFLLRKLVLP EYSIHSLFCI MFLCAQEWLT LGLNVPLLFY HFWRYFHCPA DSSELAYDPP
     VVMNADTLSY CQKEAWCKLA FYLLSFFYYL YCMIYTLVSS
 
 
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