ID   CNIH4_BOVIN             Reviewed;         139 AA.
AC   Q3T126;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Protein cornichon homolog 4;
DE            Short=CNIH-4;
DE   AltName: Full=Cornichon family AMPA receptor auxiliary protein 4;
GN   Name=CNIH4;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in G protein-coupled receptors (GPCRs) trafficking
CC       from the endoplasmic reticulum to the cell surface; it promotes the
CC       exit of GPCRs from the early secretory pathway, likely through
CC       interaction with the COPII machinery. {ECO:0000250|UniProtKB:Q9P003}.
CC   -!- SUBUNIT: Interacts with Sec23/24 complex components SEC24B and SEC24D
CC       (By similarity). Interacts with CCR5 (By similarity). Interacts with
CC       ADRB2 in the early secretory pathway (By similarity).
CC       {ECO:0000250|UniProtKB:Q9P003}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}. Endoplasmic reticulum
CC       {ECO:0000250|UniProtKB:Q9P003}. Endoplasmic reticulum-Golgi
CC       intermediate compartment {ECO:0000250|UniProtKB:Q9P003}.
CC   -!- SIMILARITY: Belongs to the cornichon family. {ECO:0000305}.
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DR   EMBL; BC102152; AAI02153.1; -; mRNA.
DR   RefSeq; NP_001029510.1; NM_001034338.2.
DR   AlphaFoldDB; Q3T126; -.
DR   SMR; Q3T126; -.
DR   STRING; 9913.ENSBTAP00000025936; -.
DR   PaxDb; Q3T126; -.
DR   Ensembl; ENSBTAT00000025936; ENSBTAP00000025936; ENSBTAG00000019471.
DR   GeneID; 508912; -.
DR   KEGG; bta:508912; -.
DR   CTD; 29097; -.
DR   VEuPathDB; HostDB:ENSBTAG00000019471; -.
DR   VGNC; VGNC:27504; CNIH4.
DR   eggNOG; KOG2729; Eukaryota.
DR   GeneTree; ENSGT00950000182834; -.
DR   HOGENOM; CLU_112942_0_1_1; -.
DR   InParanoid; Q3T126; -.
DR   OMA; YLYCMII; -.
DR   OrthoDB; 1602458at2759; -.
DR   TreeFam; TF300083; -.
DR   Proteomes; UP000009136; Chromosome 16.
DR   Bgee; ENSBTAG00000019471; Expressed in oocyte and 102 other tissues.
DR   GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IBA:GO_Central.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031730; F:CCR5 chemokine receptor binding; IEA:Ensembl.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR003377; Cornichon.
DR   Pfam; PF03311; Cornichon; 1.
DR   SMART; SM01398; Cornichon; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; ER-Golgi transport; Membrane; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..139
FT                   /note="Protein cornichon homolog 4"
FT                   /id="PRO_0000245862"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        118..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   139 AA;  16049 MW;  9FC9AB66019C6AD2 CRC64;
     MEAVVFVFSL LDCCALIFLS VYFIITLSDL ECDYINARSC CSKLNKWVIP ELVGHTLVTV
     LMLISLHWFI FLLNLPVAAW NIYRYIMVPS GNMGVFDPTE IHNRGQLKSH MKEAMIKLGF
     HLLCFFMYLY SMILALIND