CNIH4_MOUSE
ID CNIH4_MOUSE Reviewed; 139 AA.
AC Q9CX13; Q3TNM6;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Protein cornichon homolog 4;
DE Short=CNIH-4;
DE AltName: Full=Cornichon family AMPA receptor auxiliary protein 4;
GN Name=Cnih4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=BALB/cJ, and C57BL/6J; TISSUE=Lung, and Stomach;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: Involved in G protein-coupled receptors (GPCRs) trafficking
CC from the endoplasmic reticulum to the cell surface; it promotes the
CC exit of GPCRs from the early secretory pathway, likely through
CC interaction with the COPII machinery. {ECO:0000250|UniProtKB:Q9P003}.
CC -!- SUBUNIT: Interacts with Sec23/24 complex components SEC24B and SEC24D
CC (By similarity). Interacts with CCR5 (By similarity). Interacts with
CC ADRB2 in the early secretory pathway (By similarity).
CC {ECO:0000250|UniProtKB:Q9P003}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}. Endoplasmic reticulum
CC {ECO:0000250|UniProtKB:Q9P003}. Endoplasmic reticulum-Golgi
CC intermediate compartment {ECO:0000250|UniProtKB:Q9P003}.
CC -!- SIMILARITY: Belongs to the cornichon family. {ECO:0000305}.
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DR EMBL; AK021301; BAB32366.1; -; mRNA.
DR EMBL; AK144157; BAE25737.1; -; mRNA.
DR EMBL; AK165179; BAE38062.1; -; mRNA.
DR EMBL; AK166153; BAE38600.1; -; mRNA.
DR EMBL; BC065395; AAH65395.1; -; mRNA.
DR CCDS; CCDS15582.1; -.
DR RefSeq; NP_084407.1; NM_030131.3.
DR AlphaFoldDB; Q9CX13; -.
DR SMR; Q9CX13; -.
DR BioGRID; 221056; 3.
DR IntAct; Q9CX13; 1.
DR STRING; 10090.ENSMUSP00000115772; -.
DR MaxQB; Q9CX13; -.
DR PaxDb; Q9CX13; -.
DR PeptideAtlas; Q9CX13; -.
DR PRIDE; Q9CX13; -.
DR ProteomicsDB; 283403; -.
DR Antibodypedia; 34638; 77 antibodies from 17 providers.
DR DNASU; 98417; -.
DR Ensembl; ENSMUST00000134115; ENSMUSP00000115772; ENSMUSG00000062169.
DR GeneID; 98417; -.
DR KEGG; mmu:98417; -.
DR UCSC; uc007dxe.2; mouse.
DR CTD; 29097; -.
DR MGI; MGI:1925828; Cnih4.
DR VEuPathDB; HostDB:ENSMUSG00000062169; -.
DR eggNOG; KOG2729; Eukaryota.
DR GeneTree; ENSGT00950000182834; -.
DR InParanoid; Q9CX13; -.
DR OMA; YLYCMII; -.
DR OrthoDB; 1602458at2759; -.
DR PhylomeDB; Q9CX13; -.
DR TreeFam; TF300083; -.
DR BioGRID-ORCS; 98417; 5 hits in 72 CRISPR screens.
DR ChiTaRS; Cnih4; mouse.
DR PRO; PR:Q9CX13; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q9CX13; protein.
DR Bgee; ENSMUSG00000062169; Expressed in small intestine Peyer's patch and 249 other tissues.
DR ExpressionAtlas; Q9CX13; baseline and differential.
DR Genevisible; Q9CX13; MM.
DR GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031730; F:CCR5 chemokine receptor binding; ISO:MGI.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; ISS:UniProtKB.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR003377; Cornichon.
DR Pfam; PF03311; Cornichon; 1.
DR SMART; SM01398; Cornichon; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; ER-Golgi transport; Membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..139
FT /note="Protein cornichon homolog 4"
FT /id="PRO_0000122231"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 139 AA; 16089 MW; CA76B250D08EC091 CRC64;
MEAVVFLFSL LDCCALIFLS VYFIITLSDL ECDYINARSC CSKLNKWVIP ELVGHTIVTV
LMLVSLHWFI FLLNLPVATW NIYRFIMVPS GNMGVFDPTE IHNRGQLKSH MKEAMIKLGF
YLLCFFMYLY SMILALIND
