ID   CNIH4_PONAB             Reviewed;         139 AA.
AC   Q5R9M4;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Protein cornichon homolog 4;
DE            Short=CNIH-4;
DE   AltName: Full=Cornichon family AMPA receptor auxiliary protein 4;
GN   Name=CNIH4;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in G protein-coupled receptors (GPCRs) trafficking
CC       from the endoplasmic reticulum to the cell surface; it promotes the
CC       exit of GPCRs from the early secretory pathway, likely through
CC       interaction with the COPII machinery. {ECO:0000250|UniProtKB:Q9P003}.
CC   -!- SUBUNIT: Interacts with Sec23/24 complex components SEC24B and SEC24D
CC       (By similarity). Interacts with CCR5 (By similarity). Interacts with
CC       ADRB2 in the early secretory pathway (By similarity).
CC       {ECO:0000250|UniProtKB:Q9P003}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}. Endoplasmic reticulum
CC       {ECO:0000250|UniProtKB:Q9P003}. Endoplasmic reticulum-Golgi
CC       intermediate compartment {ECO:0000250|UniProtKB:Q9P003}.
CC   -!- SIMILARITY: Belongs to the cornichon family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR859362; CAH91536.1; -; mRNA.
DR   RefSeq; NP_001125902.1; NM_001132430.1.
DR   AlphaFoldDB; Q5R9M4; -.
DR   SMR; Q5R9M4; -.
DR   STRING; 9601.ENSPPYP00000000183; -.
DR   GeneID; 100172835; -.
DR   KEGG; pon:100172835; -.
DR   CTD; 29097; -.
DR   eggNOG; KOG2729; Eukaryota.
DR   InParanoid; Q5R9M4; -.
DR   OrthoDB; 1602458at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR003377; Cornichon.
DR   Pfam; PF03311; Cornichon; 1.
DR   SMART; SM01398; Cornichon; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; ER-Golgi transport; Membrane; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..139
FT                   /note="Protein cornichon homolog 4"
FT                   /id="PRO_0000122232"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        118..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   139 AA;  16093 MW;  9452E9BDEC2A8DEF CRC64;
     MEAVVFVFSL LDCCALIFLS VYFIITLSDL ECDYINARSC CSKLNKWVIP ELIGHTIVTV
     LLLMSLHWFI FLLNLPVATW NIYRYIMVPS GNMGVFDPTE IHNRGQLKSH MKEAMIKLGF
     HLLCFFMYLY SMILALIND