ID   CNIH4_XENTR             Reviewed;         139 AA.
AC   Q6P3N5;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Protein cornichon homolog 4;
DE            Short=CNIH-4;
DE   AltName: Full=Cornichon family AMPA receptor auxiliary protein 4;
GN   Name=cnih4;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in G protein-coupled receptors (GPCRs) trafficking
CC       from the endoplasmic reticulum to the cell surface; it promotes the
CC       exit of GPCRs from the early secretory pathway, likely through
CC       interaction with the COPII machinery. {ECO:0000250|UniProtKB:Q9P003}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}. Endoplasmic reticulum
CC       {ECO:0000250|UniProtKB:Q9P003}. Endoplasmic reticulum-Golgi
CC       intermediate compartment {ECO:0000250|UniProtKB:Q9P003}.
CC   -!- SIMILARITY: Belongs to the cornichon family. {ECO:0000305}.
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DR   EMBL; BC063923; AAH63923.1; -; mRNA.
DR   RefSeq; NP_989292.1; NM_203961.1.
DR   AlphaFoldDB; Q6P3N5; -.
DR   SMR; Q6P3N5; -.
DR   STRING; 8364.ENSXETP00000040193; -.
DR   PaxDb; Q6P3N5; -.
DR   DNASU; 394910; -.
DR   Ensembl; ENSXETT00000075768; ENSXETP00000095351; ENSXETG00000037711.
DR   GeneID; 394910; -.
DR   KEGG; xtr:394910; -.
DR   CTD; 29097; -.
DR   Xenbase; XB-GENE-993717; cnih4.
DR   eggNOG; KOG2729; Eukaryota.
DR   HOGENOM; CLU_112942_0_1_1; -.
DR   InParanoid; Q6P3N5; -.
DR   OMA; KNHYLID; -.
DR   OrthoDB; 1602458at2759; -.
DR   PhylomeDB; Q6P3N5; -.
DR   TreeFam; TF300083; -.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000037711; Expressed in egg cell and 13 other tissues.
DR   GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IBA:GO_Central.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR003377; Cornichon.
DR   Pfam; PF03311; Cornichon; 1.
DR   SMART; SM01398; Cornichon; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; ER-Golgi transport; Membrane; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..139
FT                   /note="Protein cornichon homolog 4"
FT                   /id="PRO_0000122233"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        60..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        118..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   139 AA;  15941 MW;  0E6E0EDA7F59811F CRC64;
     MEAALFIFSL IDCCALIFLS VYFIITLSDL ECDYINARSC CSKLNKWVVP ELVGHTVVSV
     LMLVSLHWFI FILNLPVAAW NIYRFIMVPS GNLGVFDPTE IHNRGQLKSH MKEAMIKLGF
     HLLCFFIYLY SMILALIND