ID   CNI_DROVI               Reviewed;         144 AA.
AC   P52159; B4LTD4;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 2.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Protein cornichon;
GN   Name=cni; ORFNames=GJ17163;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Ovary;
RX   PubMed=7540118; DOI=10.1016/0092-8674(95)90016-0;
RA   Roth S., Neuman-Silberberg F.S., Barcelo G., Schuepbach T.;
RT   "Cornichon and the EGF receptor signaling process are necessary for both
RT   anterior-posterior and dorsal-ventral pattern formation in Drosophila.";
RL   Cell 81:967-978(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15010-1051.87;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Acts as cargo receptor necessary for the transportation of
CC       gurken (grk) to a transitional endoplasmic reticulum (tER) site and
CC       promotes its incorporation into coat protein complex II (COPII)
CC       vesicles. Associated with gurken, produces a signal received by torpedo
CC       resulting in a signaling pathway that first establishes posterior
CC       follicle cell fates and normal localization of the anterior and
CC       posterior determinants, later they act in a signaling event inducing
CC       dorsal follicle cell fates and regulating the dorsal-ventral pattern of
CC       egg and embryo (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with grk. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cornichon family. {ECO:0000305}.
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DR   EMBL; CH940649; EDW63904.1; -; Genomic_DNA.
DR   RefSeq; XP_002051749.1; XM_002051713.2.
DR   RefSeq; XP_015028255.1; XM_015172769.1.
DR   AlphaFoldDB; P52159; -.
DR   SMR; P52159; -.
DR   STRING; 7244.FBpp0231580; -.
DR   EnsemblMetazoa; FBtr0233088; FBpp0231580; FBgn0266015.
DR   EnsemblMetazoa; FBtr0437082; FBpp0393936; FBgn0266015.
DR   GeneID; 6627732; -.
DR   KEGG; dvi:6627732; -.
DR   eggNOG; KOG2729; Eukaryota.
DR   HOGENOM; CLU_112942_1_0_1; -.
DR   InParanoid; P52159; -.
DR   OMA; WIAFLLN; -.
DR   OrthoDB; 1602458at2759; -.
DR   PhylomeDB; P52159; -.
DR   Proteomes; UP000008792; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IEA:EnsemblMetazoa.
DR   GO; GO:0007350; P:blastoderm segmentation; IEA:EnsemblMetazoa.
DR   GO; GO:0046843; P:dorsal appendage formation; IEA:EnsemblMetazoa.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; ISS:UniProtKB.
DR   GO; GO:0007310; P:oocyte dorsal/ventral axis specification; IEA:EnsemblMetazoa.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR003377; Cornichon.
DR   InterPro; IPR033466; Cornichon_conserved.
DR   Pfam; PF03311; Cornichon; 1.
DR   SMART; SM01398; Cornichon; 1.
DR   PROSITE; PS01340; CORNICHON; 1.
PE   3: Inferred from homology;
KW   Developmental protein; Endoplasmic reticulum; ER-Golgi transport; Membrane;
KW   Protein transport; Receptor; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..144
FT                   /note="Protein cornichon"
FT                   /id="PRO_0000122235"
FT   TOPO_DOM        1..10
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        32..56
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        78..122
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        123..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        144
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          1..57
FT                   /note="Interaction with grk"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        113
FT                   /note="S -> F (in Ref. 1)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   144 AA;  16867 MW;  A62F965560409170 CRC64;
     MAFNFTAFTY IVALIGDAFL IFFAIFHVIA FDELKTDYKN PIDQCNSLNP LVLPEYLLHL
     FLNLLFLFCG EWYSLCLNIP LIAYHIWRYK NRPLMSGPGL YDPTTVLKTD TLSRNLREGW
     IKLAVYLISF FYYIYGMVYS LIST