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CNKR2_RAT
ID   CNKR2_RAT               Reviewed;        1032 AA.
AC   Q9Z1T4; Q9R093;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 150.
DE   RecName: Full=Connector enhancer of kinase suppressor of ras 2;
DE            Short=Connector enhancer of KSR 2;
DE   AltName: Full=CNK homolog protein 2;
DE            Short=CNK2;
DE   AltName: Full=Membrane-associated guanylate kinase-interacting protein;
DE            Short=Maguin;
GN   Name=Cnksr2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, AND
RP   INTERACTION WITH DLG4 AND AIP1.
RX   PubMed=10207009; DOI=10.1074/jbc.274.17.11889;
RA   Yao I., Hata Y., Ide N., Hirao K., Deguchi M., Nishioka H., Mizoguchi A.,
RA   Takai Y.;
RT   "MAGUIN, a novel neuronal membrane-associated guanylate kinase-interacting
RT   protein.";
RL   J. Biol. Chem. 274:11889-11896(1999).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-390; SER-685; SER-687;
RP   SER-756; SER-767 AND SER-906, AND IDENTIFICATION BY MASS SPECTROMETRY
RP   [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- FUNCTION: May function as an adapter protein or regulator of Ras
CC       signaling pathways, in synaptic junctions.
CC   -!- SUBUNIT: Interacts with RAF1, RAB2L and RAL GTPase proteins (By
CC       similarity). Interacts with DLG4 and AIP1. {ECO:0000250,
CC       ECO:0000269|PubMed:10207009}.
CC   -!- INTERACTION:
CC       Q9Z1T4; Q9Z1T4: Cnksr2; NbExp=2; IntAct=EBI-8548356, EBI-8548356;
CC       Q9Z1T4; P31016: Dlg4; NbExp=4; IntAct=EBI-8548356, EBI-375655;
CC       Q9Z1T4; P70587: Lrrc7; NbExp=3; IntAct=EBI-8548356, EBI-7798464;
CC       Q9Z1T4; Q96NW7: LRRC7; Xeno; NbExp=2; IntAct=EBI-8548356, EBI-524275;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1; Synonyms=Maguin-1;
CC         IsoId=Q9Z1T4-1; Sequence=Displayed;
CC       Name=2; Synonyms=Maguin-2;
CC         IsoId=Q9Z1T4-2; Sequence=VSP_010891, VSP_010892;
CC   -!- TISSUE SPECIFICITY: Expressed in neurons and localized in the cell body
CC       and neurites. {ECO:0000269|PubMed:10207009}.
CC   -!- PTM: Phosphorylated on tyrosine. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CNKSR family. {ECO:0000305}.
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DR   EMBL; AF102853; AAD04567.1; -; mRNA.
DR   EMBL; AF102854; AAD04568.1; -; mRNA.
DR   PIR; T18293; T18293.
DR   RefSeq; NP_001106837.1; NM_001113366.1. [Q9Z1T4-1]
DR   RefSeq; NP_067718.1; NM_021686.3. [Q9Z1T4-2]
DR   AlphaFoldDB; Q9Z1T4; -.
DR   SMR; Q9Z1T4; -.
DR   BioGRID; 248765; 3.
DR   IntAct; Q9Z1T4; 4.
DR   MINT; Q9Z1T4; -.
DR   STRING; 10116.ENSRNOP00000009802; -.
DR   iPTMnet; Q9Z1T4; -.
DR   PhosphoSitePlus; Q9Z1T4; -.
DR   PaxDb; Q9Z1T4; -.
DR   PRIDE; Q9Z1T4; -.
DR   Ensembl; ENSRNOT00000009802; ENSRNOP00000009802; ENSRNOG00000007014. [Q9Z1T4-1]
DR   Ensembl; ENSRNOT00000080512; ENSRNOP00000071915; ENSRNOG00000007014. [Q9Z1T4-2]
DR   GeneID; 59322; -.
DR   KEGG; rno:59322; -.
DR   CTD; 22866; -.
DR   RGD; 708454; Cnksr2.
DR   eggNOG; KOG1738; Eukaryota.
DR   GeneTree; ENSGT00940000156709; -.
DR   InParanoid; Q9Z1T4; -.
DR   OMA; EDMEMPP; -.
DR   OrthoDB; 1121556at2759; -.
DR   PhylomeDB; Q9Z1T4; -.
DR   TreeFam; TF326495; -.
DR   Reactome; R-RNO-5674135; MAP2K and MAPK activation.
DR   PRO; PR:Q9Z1T4; -.
DR   Proteomes; UP000002494; Chromosome X.
DR   Bgee; ENSRNOG00000007014; Expressed in frontal cortex and 9 other tissues.
DR   Genevisible; Q9Z1T4; RN.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0099147; C:extrinsic component of postsynaptic density membrane; IDA:SynGO.
DR   GO; GO:0098978; C:glutamatergic synapse; IDA:SynGO.
DR   GO; GO:0043005; C:neuron projection; IDA:RGD.
DR   GO; GO:0043025; C:neuronal cell body; IDA:RGD.
DR   GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR   GO; GO:0014069; C:postsynaptic density; IDA:RGD.
DR   GO; GO:0045211; C:postsynaptic membrane; IDA:RGD.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0019901; F:protein kinase binding; ISO:RGD.
DR   GO; GO:0035556; P:intracellular signal transduction; ISO:RGD.
DR   GO; GO:0099173; P:postsynapse organization; IDA:SynGO.
DR   GO; GO:0009966; P:regulation of signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.150.50; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   InterPro; IPR010599; CNK2/3_dom.
DR   InterPro; IPR017874; CRIC_domain.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   Pfam; PF10534; CRIC_ras_sig; 1.
DR   Pfam; PF06663; DUF1170; 1.
DR   Pfam; PF00595; PDZ; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00536; SAM_1; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00454; SAM; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   SUPFAM; SSF50156; SSF50156; 1.
DR   PROSITE; PS51290; CRIC; 1.
DR   PROSITE; PS50106; PDZ; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Coiled coil; Cytoplasm; Membrane; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..1032
FT                   /note="Connector enhancer of kinase suppressor of ras 2"
FT                   /id="PRO_0000089972"
FT   DOMAIN          11..76
FT                   /note="SAM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT   DOMAIN          84..178
FT                   /note="CRIC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00621"
FT   DOMAIN          215..297
FT                   /note="PDZ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT   DOMAIN          332..515
FT                   /note="DUF1170"
FT   DOMAIN          570..669
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   REGION          324..349
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          480..509
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          682..766
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          866..900
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          874..917
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        324..346
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        682..696
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        698..712
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        726..766
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        871..890
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         12
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q80YA9"
FT   MOD_RES         338
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q80YA9"
FT   MOD_RES         390
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         683
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q80YA9"
FT   MOD_RES         685
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         687
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         756
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         767
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         906
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   VAR_SEQ         896
FT                   /note="N -> S (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:10207009"
FT                   /id="VSP_010891"
FT   VAR_SEQ         897..1032
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:10207009"
FT                   /id="VSP_010892"
SQ   SEQUENCE   1032 AA;  117390 MW;  02BD762461F8D7EC CRC64;
     MALIMEPVSK WSPSQVVDWM KGLDDCLQQY IKNFEREKIS GDQLLRITHQ ELEDLGVSRI
     GHQELILEAV DLLCALNYGL ETENLKTLSH KLNASAKNLQ NFITGRRRSG HYDGRTSRKL
     PNDFLTSVVD LIGAAKSLLA WLDRSPFAAV TDYSVTRNNV IQLCLELTTI VQQDCTVYET
     ENKILHVCKT LSGVCDHIIS LSSDPLVSQS AHLEVIQLAN IKPSEGLGMY IKSTYDGLHV
     ITGTTENSPA DRCKKIHAGD EVIQVNHQTV VGWQLKNLVN ALREDPSGVI LTLKKRPQSM
     LTSAPALLKN MRWKPLALQP LIPRSPTSSV ATPSSTISTP TKRDSSALQD LYIPPPPAEP
     YIPRDEKGNL PCEDLRGHMV GKPVHKGSES PNSFLDQEYR KRFNIVEEDT VLYCYEYEKG
     RSSSQGRRES TPTYGKLRPI SMPVEYNWVG DYEDPNKMKR DSRRENSLLR YMSNEKIAQE
     EYMFQRNSKK DTGKKSKKKG DKSTSPTHYS LLPSLQMDAL RQDIMGTPVP ETTLYHTFQQ
     SSLQHKSKKK NKGAIAGKSK RRISCKDLGR GDCEGWLWKK KDAKSYFSQK WKKYWFVLKD
     ASLYWYINEE DEKAEGFISL PEFKIDRASE CRKKYAFKAC HPKIKSFYFA AEHLDDMNRW
     LNRINMLTAG YAERERIKQE QDYWSESDKE EADTPSTPKQ DSPPPPYDTY PRPPSMSCAS
     PYVEAKHSRL SSTETSQSQS SHEEFRQEVT GSSAVSPIRK TASQRRSWQD LIETPLTSSG
     LHYLQTLPLE DSVFSDSAAI SPEHRRQSTL PTQKCHLQDH YGPYPLAESE RMQVLNGNGG
     KPRSFTLPRD SGFNHCCLNA PVSACDPQDD IQPPEVEEEE EEEEEEAAGE NIGEKNENRE
     EKLGDSLQDL YRALEEASLS PLGEHRISTK IEYKLSFIKR CNDPVMNEKL HRLRILKSTL
     KAREGEVAII DKVLDNPDLT SKEFQQWKQM YLDLFLDICQ NTTSNDPLSI SSEVDVITSS
     LTHTHSYIET HV
 
 
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