CNN1_SHEEP
ID CNN1_SHEEP Reviewed; 297 AA.
AC Q7YRL2;
DT 18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=Calponin-1;
DE AltName: Full=Basic calponin;
DE AltName: Full=Calponin H1, smooth muscle;
GN Name=CNN1;
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Yue Z., Huang Z., Song J., Zhang Y., Liu H., Cheng H., Ma R.Z.;
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Thin filament-associated protein that is implicated in the
CC regulation and modulation of smooth muscle contraction. It is capable
CC of binding to actin, calmodulin and tropomyosin. The interaction of
CC calponin with actin inhibits the actomyosin Mg-ATPase activity (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Part of cGMP kinase signaling complex at least composed of
CC ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and
CC ITPR1. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the calponin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY327118; AAP88264.1; -; mRNA.
DR RefSeq; NP_001009456.1; NM_001009456.1.
DR AlphaFoldDB; Q7YRL2; -.
DR SMR; Q7YRL2; -.
DR STRING; 9940.ENSOARP00000019989; -.
DR Ensembl; ENSOART00000020266; ENSOARP00000019989; ENSOARG00000018621.
DR Ensembl; ENSOART00020011120; ENSOARP00020009141; ENSOARG00020007271.
DR GeneID; 443517; -.
DR KEGG; oas:443517; -.
DR CTD; 1264; -.
DR eggNOG; KOG2046; Eukaryota.
DR HOGENOM; CLU_055232_0_0_1; -.
DR OMA; GEPTHNH; -.
DR OrthoDB; 861989at2759; -.
DR Proteomes; UP000002356; Chromosome 5.
DR Bgee; ENSOARG00000018621; Expressed in rectum and 51 other tissues.
DR GO; GO:0005856; C:cytoskeleton; IEA:Ensembl.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0031032; P:actomyosin structure organization; IEA:InterPro.
DR GO; GO:1904706; P:negative regulation of vascular associated smooth muscle cell proliferation; IEA:Ensembl.
DR CDD; cd00014; CH; 1.
DR Gene3D; 1.10.418.10; -; 1.
DR InterPro; IPR001997; Calponin/LIMCH1.
DR InterPro; IPR000557; Calponin_repeat.
DR InterPro; IPR001715; CH-domain.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR003096; SM22_calponin.
DR Pfam; PF00402; Calponin; 3.
DR Pfam; PF00307; CH; 1.
DR PRINTS; PR00889; CALPONIN.
DR PRINTS; PR00888; SM22CALPONIN.
DR SMART; SM00033; CH; 1.
DR SUPFAM; SSF47576; SSF47576; 1.
DR PROSITE; PS01052; CALPONIN_1; 3.
DR PROSITE; PS51122; CALPONIN_2; 3.
DR PROSITE; PS50021; CH; 1.
PE 2: Evidence at transcript level;
KW Actin-binding; Calmodulin-binding; Phosphoprotein; Reference proteome;
KW Repeat.
FT CHAIN 1..297
FT /note="Calponin-1"
FT /id="PRO_0000232496"
FT DOMAIN 28..131
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT REPEAT 164..189
FT /note="Calponin-like 1"
FT REPEAT 204..229
FT /note="Calponin-like 2"
FT REPEAT 243..268
FT /note="Calponin-like 3"
FT MOD_RES 170
FT /note="Phosphothreonine; by ROCK2"
FT /evidence="ECO:0000250"
FT MOD_RES 175
FT /note="Phosphoserine; by ROCK2"
FT /evidence="ECO:0000250"
FT MOD_RES 180
FT /note="Phosphothreonine; by ROCK2"
FT /evidence="ECO:0000250"
FT MOD_RES 184
FT /note="Phosphothreonine; by ROCK2"
FT /evidence="ECO:0000250"
FT MOD_RES 259
FT /note="Phosphothreonine; by ROCK2"
FT /evidence="ECO:0000250"
SQ SEQUENCE 297 AA; 33255 MW; 254E9C17F221E026 CRC64;
MSSAHFNRGP AYGLSAEVKN KLAQKYDHQR EQELREWIEG VTGRRIGNNF MDGLKDGIIL
CEFINKLQPG SVKKVNESTQ NWHQLENIGN FIKAITKYGV KPHDIFEAND LFENTNHTQV
QSTLLALASM AKTKGNKVNV GVKYAEKQER KFEPEKLREG RNIIGLQMGT NKFASQQGMT
AYGTRRHLYD PKLGTDQPLD QATISLQMGT NKGASQAGMT APGTKRQIFE PGLGMEHCDT
LNVSLQMGSN KGASQRGMTV YGLPRQVYDP KYCLTPEYPE LGEPAHNHHP HNYYNSA