ID   CNN2_PIG                Reviewed;         296 AA.
AC   Q08094;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Calponin-2;
DE   AltName: Full=Calponin H2, smooth muscle;
DE   AltName: Full=Neutral calponin;
DE   Flags: Fragment;
GN   Name=CNN2;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Smooth muscle;
RX   PubMed=8370452; DOI=10.1016/0014-5793(93)80909-e;
RA   Strasser P., Gimona M., Moessler H., Herzog M., Small J.V.;
RT   "Mammalian calponin. Identification and expression of genetic variants.";
RL   FEBS Lett. 330:13-18(1993).
CC   -!- FUNCTION: Thin filament-associated protein that is implicated in the
CC       regulation and modulation of smooth muscle contraction. It is capable
CC       of binding to actin, calmodulin and tropomyosin. The interaction of
CC       calponin with actin inhibits the actomyosin Mg-ATPase activity.
CC   -!- TISSUE SPECIFICITY: Smooth muscle, and tissues containing significant
CC       amounts of smooth muscle.
CC   -!- SIMILARITY: Belongs to the calponin family. {ECO:0000305}.
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DR   EMBL; Z19539; CAA79599.1; -; mRNA.
DR   PIR; S36148; S31483.
DR   AlphaFoldDB; Q08094; -.
DR   SMR; Q08094; -.
DR   STRING; 9823.ENSSSCP00000027795; -.
DR   PeptideAtlas; Q08094; -.
DR   PRIDE; Q08094; -.
DR   eggNOG; KOG2046; Eukaryota.
DR   InParanoid; Q08094; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005884; C:actin filament; IBA:GO_Central.
DR   GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR   GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR   GO; GO:0008093; F:cytoskeletal anchor activity; IBA:GO_Central.
DR   GO; GO:0051764; P:actin crosslink formation; IBA:GO_Central.
DR   GO; GO:0031032; P:actomyosin structure organization; IEA:InterPro.
DR   CDD; cd00014; CH; 1.
DR   Gene3D; 1.10.418.10; -; 1.
DR   InterPro; IPR001997; Calponin/LIMCH1.
DR   InterPro; IPR000557; Calponin_repeat.
DR   InterPro; IPR001715; CH-domain.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR029974; CNN2.
DR   InterPro; IPR003096; SM22_calponin.
DR   PANTHER; PTHR46756:SF2; PTHR46756:SF2; 1.
DR   Pfam; PF00402; Calponin; 3.
DR   Pfam; PF00307; CH; 1.
DR   PRINTS; PR00889; CALPONIN.
DR   PRINTS; PR00888; SM22CALPONIN.
DR   SMART; SM00033; CH; 1.
DR   SUPFAM; SSF47576; SSF47576; 1.
DR   PROSITE; PS01052; CALPONIN_1; 3.
DR   PROSITE; PS51122; CALPONIN_2; 3.
DR   PROSITE; PS50021; CH; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Actin-binding; Calmodulin-binding; Phosphoprotein;
KW   Reference proteome; Repeat.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q99439"
FT   CHAIN           2..>296
FT                   /note="Calponin-2"
FT                   /id="PRO_0000204775"
FT   DOMAIN          28..132
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT   REPEAT          166..191
FT                   /note="Calponin-like 1"
FT   REPEAT          206..231
FT                   /note="Calponin-like 2"
FT   REPEAT          245..269
FT                   /note="Calponin-like 3"
FT   REGION          275..296
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q99439"
FT   MOD_RES         8
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q99439"
FT   MOD_RES         25
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q99439"
FT   MOD_RES         138
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q99439"
FT   NON_TER         296
SQ   SEQUENCE   296 AA;  32030 MW;  921164B374B50FDC CRC64;
     MSSTQFNKGP SYGLSAEVKN RLLSKYDPQK EAELRSWIEG LTGLSIGPDF QKGLKDGIIL
     CTLMNKLQPG SVPKINRSMQ NWHQLENLSN FIKAMVSYGM NPVDLFEAND LFESGNMTQV
     QVSLLALAGK AKTKGLQSDV DIGVKYSEKQ QRNFDDATMK AGQCVIGLQM GTNKCASQSG
     MTAYGTRRHL YDPKNHILPP MDHSTISLQM GTNKCASQVG MTAPGTRRHI YDTKLGTDKC
     DNSSMSLQMG YTQGANQSGQ VFGLGRQIYD PKYCPQGPAA DGAPAAAGDC PGPGES