ID   CNN3_BOVIN              Reviewed;         329 AA.
AC   Q32L92;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Calponin-3;
DE   AltName: Full=Calponin, acidic isoform;
GN   Name=CNN3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Thin filament-associated protein that is implicated in the
CC       regulation and modulation of smooth muscle contraction. It is capable
CC       of binding to actin, calmodulin and tropomyosin. The interaction of
CC       calponin with actin inhibits the actomyosin Mg-ATPase activity (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the calponin family. {ECO:0000305}.
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DR   EMBL; BC109697; AAI09698.1; -; mRNA.
DR   RefSeq; NP_001033268.1; NM_001038179.1.
DR   AlphaFoldDB; Q32L92; -.
DR   SMR; Q32L92; -.
DR   STRING; 9913.ENSBTAP00000027115; -.
DR   PaxDb; Q32L92; -.
DR   PeptideAtlas; Q32L92; -.
DR   PRIDE; Q32L92; -.
DR   Ensembl; ENSBTAT00000027115; ENSBTAP00000027115; ENSBTAG00000020345.
DR   GeneID; 538975; -.
DR   KEGG; bta:538975; -.
DR   CTD; 1266; -.
DR   VEuPathDB; HostDB:ENSBTAG00000020345; -.
DR   eggNOG; KOG2046; Eukaryota.
DR   GeneTree; ENSGT00940000154539; -.
DR   HOGENOM; CLU_055232_0_1_1; -.
DR   InParanoid; Q32L92; -.
DR   OMA; TMTHFNK; -.
DR   OrthoDB; 861989at2759; -.
DR   TreeFam; TF313921; -.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000020345; Expressed in neurohypophysis and 104 other tissues.
DR   GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR   GO; GO:0008017; F:microtubule binding; ISS:AgBase.
DR   GO; GO:0031032; P:actomyosin structure organization; IEA:InterPro.
DR   CDD; cd00014; CH; 1.
DR   Gene3D; 1.10.418.10; -; 1.
DR   InterPro; IPR001997; Calponin/LIMCH1.
DR   InterPro; IPR000557; Calponin_repeat.
DR   InterPro; IPR001715; CH-domain.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR003096; SM22_calponin.
DR   Pfam; PF00402; Calponin; 3.
DR   Pfam; PF00307; CH; 1.
DR   PRINTS; PR00889; CALPONIN.
DR   PRINTS; PR00888; SM22CALPONIN.
DR   SMART; SM00033; CH; 1.
DR   SUPFAM; SSF47576; SSF47576; 1.
DR   PROSITE; PS01052; CALPONIN_1; 3.
DR   PROSITE; PS51122; CALPONIN_2; 3.
DR   PROSITE; PS50021; CH; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Actin-binding; Calmodulin-binding; Methylation;
KW   Reference proteome; Repeat.
FT   CHAIN           1..329
FT                   /note="Calponin-3"
FT                   /id="PRO_0000244392"
FT   DOMAIN          26..130
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT   REPEAT          164..189
FT                   /note="Calponin-like 1"
FT   REPEAT          204..229
FT                   /note="Calponin-like 2"
FT   REPEAT          243..268
FT                   /note="Calponin-like 3"
FT   REGION          280..329
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        281..298
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        302..318
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         23
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9DAW9"
FT   MOD_RES         158
FT                   /note="N6-methyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q15417"
SQ   SEQUENCE   329 AA;  36358 MW;  FF81146DBC34F013 CRC64;
     MTHFNKGPSY GLSAEVKNKI ASKYDHQAEE DLRNWIEEVT GMSIGANFQL GLKDGIILCE
     LINKLQPGSV KKVNESSLNW PQLENIGNFI KAIQAYGMKP HDIFEANDLF ENGNMTQVQT
     TLVALAGLAK TKGFHTTIDI GVKYAEKQTR RFDEGKLKAG QSVIGLQMGT NKCASQAGMT
     AYGTRRHLYD PKMQTDKPFD QTTISLQMGT NKGASQAGML APGTRRDIYD QKLTLQPVDN
     STISLQMGTN KVASQKGMSV YGLGRQVYDP KYCAAPTEPV IHNGSQGTGT NGSEISDSDY
     QAEYPDEYHG EYQDDYPRDY QYGDQGIDY