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CNNM2_RAT
ID   CNNM2_RAT               Reviewed;         875 AA.
AC   Q5U2P1;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Metal transporter CNNM2;
DE   AltName: Full=Ancient conserved domain-containing protein 2;
DE   AltName: Full=Cyclin-M2;
GN   Name=Cnnm2; Synonyms=Acdp2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Divalent metal cation transporter. Mediates transport of
CC       divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+)
CC       > Ba(2+) > Cu(2+) > Fe(2+).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- MISCELLANEOUS: Shares weak sequence similarity with the cyclin family,
CC       hence its name. However, it has no cyclin-like function in vivo.
CC   -!- SIMILARITY: Belongs to the ACDP family. {ECO:0000305}.
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DR   EMBL; BC085930; AAH85930.1; -; mRNA.
DR   RefSeq; NP_001011942.1; NM_001011942.1.
DR   AlphaFoldDB; Q5U2P1; -.
DR   SMR; Q5U2P1; -.
DR   STRING; 10116.ENSRNOP00000051583; -.
DR   GlyGen; Q5U2P1; 1 site.
DR   iPTMnet; Q5U2P1; -.
DR   PhosphoSitePlus; Q5U2P1; -.
DR   jPOST; Q5U2P1; -.
DR   PaxDb; Q5U2P1; -.
DR   Ensembl; ENSRNOT00000054699; ENSRNOP00000051583; ENSRNOG00000020113.
DR   GeneID; 294014; -.
DR   KEGG; rno:294014; -.
DR   UCSC; RGD:1308162; rat.
DR   CTD; 54805; -.
DR   RGD; 1308162; Cnnm2.
DR   eggNOG; KOG2118; Eukaryota.
DR   GeneTree; ENSGT00940000159034; -.
DR   HOGENOM; CLU_011310_1_1_1; -.
DR   InParanoid; Q5U2P1; -.
DR   OMA; CFMITAE; -.
DR   OrthoDB; 1446644at2759; -.
DR   PhylomeDB; Q5U2P1; -.
DR   TreeFam; TF101012; -.
DR   PRO; PR:Q5U2P1; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000020113; Expressed in kidney and 19 other tissues.
DR   Genevisible; Q5U2P1; RN.
DR   GO; GO:0016323; C:basolateral plasma membrane; ISO:RGD.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR   GO; GO:0005524; F:ATP binding; ISO:RGD.
DR   GO; GO:0015095; F:magnesium ion transmembrane transporter activity; ISO:RGD.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0010960; P:magnesium ion homeostasis; ISO:RGD.
DR   GO; GO:0015693; P:magnesium ion transport; ISO:RGD.
DR   CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   Gene3D; 3.10.580.10; -; 1.
DR   InterPro; IPR045095; ACDP.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR002550; CNNM.
DR   InterPro; IPR044751; Ion_transp-like_CBS.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   PANTHER; PTHR12064; PTHR12064; 1.
DR   Pfam; PF00571; CBS; 1.
DR   Pfam; PF01595; DUF21; 1.
DR   SUPFAM; SSF54631; SSF54631; 1.
DR   PROSITE; PS51371; CBS; 2.
DR   PROSITE; PS51846; CNNM; 1.
PE   2: Evidence at transcript level;
KW   CBS domain; Cell membrane; Glycoprotein; Ion transport; Membrane;
KW   Phosphoprotein; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..875
FT                   /note="Metal transporter CNNM2"
FT                   /id="PRO_0000295762"
FT   TOPO_DOM        1..250
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        251..271
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        272..313
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   INTRAMEM        314..334
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        335..338
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        339..359
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        360..368
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        369..389
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        390..875
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          251..431
FT                   /note="CNNM transmembrane"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01193"
FT   DOMAIN          450..511
FT                   /note="CBS 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT   DOMAIN          518..584
FT                   /note="CBS 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT   REGION          122..148
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          741..763
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         761
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H8M5"
FT   CARBOHYD        112
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   875 AA;  96609 MW;  67F24F5315D6BD11 CRC64;
     MIGCGACEPE VKMAGGQAAA ALPTWKMAAR RSLSARGRGV LQAAAGRLLP LLLLSCCCSA
     GGCTAAGENE ETVIIGLRLE DTNDVSFMEG GALRVSERTR VKLRVYGQNI NNETWSRIAF
     TEHERRRHTP GERGLGGPAP PEPDSGPQRC GIRTSDIIIL PHIILNRRTS GIIEIEIKPL
     RKMEKSKSYY LCTSLSTPAL GAGGSGSASG TVGGKGGAGV AGLPPPPWAE TTWIYHDGED
     TKMIVGEEKK FLLPFWLQVI FISLLLCLSG MFSGLNLGLM ALDPMELRIV QNCGTEKEKN
     YAKRIEPVRR QGNYLLCSLL LGNVLVNTTL TILLDDIAGS GLVAVVVSTI GIVIFGEIVP
     QAICSRHGLA VGANTIFLTK FFMMMTFPAS YPVSKLLDCV LGQEIGTVYN REKLLEMLRV
     TDPYNDLVKE ELNIIQGALE LRTKTVEDVM TPLRDCFMIT GEAILDFNTM SEIMESGYTR
     IPVFEGERSN IVDLLFVKDL AFVDPDDCTP LKTITKFYNH PLHFVFNDTK LDAMLEEFKK
     GKSHLAIVQR VNNEGEGDPF YEVLGIVTLE DVIEEIIKSE ILDETDLYTD NRTKKKVAHR
     ERKQDFSAFK QTDSETKVKI SPQLLLAMHR FLATEVEAFS PSQMSEKILL RLLKHPNVIQ
     ELKYDEKNKK APECYLYQRN KPVDYFVLIL QGKVEVEAGK EGMKFEASAF SYYGVMALTA
     SPVPLSLSRT FVVSRTEVLA AGSPGENKSP PRPCGLNHSD SLSRSDRIDA MTPTLGSSNN
     QLSSSFLQVY IPDYSVRALS DLQFVKISRQ QYQNALMASR MDKTPQSSDS ENTKIELTLT
     EMHDGLPDET ANLLNEQNCV SHNKANHSLH SEGAI
 
 
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