CNNM4_XENTR
ID CNNM4_XENTR Reviewed; 769 AA.
AC A0JPA0;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 12-DEC-2006, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Metal transporter CNNM4;
DE AltName: Full=Ancient conserved domain-containing protein 4;
DE AltName: Full=Cyclin-M4;
GN Name=cnnm4; Synonyms=acdp4;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probable metal transporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- MISCELLANEOUS: Shares weak sequence similarity with the cyclin family,
CC hence its name. However, it has no cyclin-like function in vivo.
CC -!- SIMILARITY: Belongs to the ACDP family. {ECO:0000305}.
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DR EMBL; BC127319; AAI27320.1; -; mRNA.
DR RefSeq; NP_001090672.1; NM_001097203.1.
DR AlphaFoldDB; A0JPA0; -.
DR SMR; A0JPA0; -.
DR PaxDb; A0JPA0; -.
DR DNASU; 100036645; -.
DR GeneID; 100036645; -.
DR KEGG; xtr:100036645; -.
DR CTD; 26504; -.
DR Xenbase; XB-GENE-999369; cnnm4.
DR eggNOG; KOG2118; Eukaryota.
DR HOGENOM; CLU_011310_1_1_1; -.
DR InParanoid; A0JPA0; -.
DR OMA; KLMFMHA; -.
DR OrthoDB; 1446644at2759; -.
DR PhylomeDB; A0JPA0; -.
DR TreeFam; TF101012; -.
DR Proteomes; UP000008143; Chromosome 3.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000001249; Expressed in 4-cell stage embryo and 13 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015081; F:sodium ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0010960; P:magnesium ion homeostasis; IBA:GO_Central.
DR GO; GO:0015693; P:magnesium ion transport; IBA:GO_Central.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.10.580.10; -; 1.
DR InterPro; IPR045095; ACDP.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR002550; CNNM.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR PANTHER; PTHR12064; PTHR12064; 1.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF01595; DUF21; 1.
DR SUPFAM; SSF54631; SSF54631; 1.
DR PROSITE; PS51371; CBS; 2.
DR PROSITE; PS51846; CNNM; 1.
PE 2: Evidence at transcript level;
KW CBS domain; Cell membrane; Glycoprotein; Ion transport; Membrane;
KW Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..769
FT /note="Metal transporter CNNM4"
FT /id="PRO_0000295768"
FT TOPO_DOM 1..175
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 197..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT INTRAMEM 238..258
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..261
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 262..282
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 283..292
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 293..313
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 314..769
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 175..355
FT /note="CNNM transmembrane"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01193"
FT DOMAIN 374..435
FT /note="CBS 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT DOMAIN 442..508
FT /note="CBS 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT REGION 717..769
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 717..735
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 750..769
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 99
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 115
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 769 AA; 85402 MW; A06BF749F1C8AC0F CRC64;
MAASAGCYYG VLGCALSLLL LPPLSRCAAR TDSPLPEELP LILGFRLERS DRHAALSPDG
ELEVVEGSRL ELRVYGLHLR EDSGHILAFT EYSPGSQDNR SCLEDSRDLV LTRLNVSDDG
FGAAGAAIVR LDVLPLRKSQ SSRVYVLCTS RGPGLPWKLH TGPDGRLRVL EEEKPLLPIW
LQACIIAVLL TLSGIFSGLN LGLMALDPME LRVVQRCGTE KEKRYASKIE PVRRKGNYLL
CSLLLGNVLV NTTLTALLDE LIGSGLAAVL ASTTGIVVLG EIVPQALCSR HGLAVGANTL
WLTRIFMLLT FPVAYPVSRL LDCALGQEIG TVYNREKLLE MLKVTEPYSG IVREEMNIIQ
GALELRTKTV EDVMTKVEDC FMLPSDAVLD FNTMSSIMES GYTRIPVYEN ERSNIVDILY
VKDLAFVDPD DCTPLSTITR FYSHPLHFVF SDTKLDAVLE EFKKGKSHLA IVQKVNSEGE
GDPFYEVMGL VTLEDVIEEI IKSEILDESD LYTDNRSKKR VKRRQDRKDF SVFKDADNEL
RVKISPQLLL AAHRFLSTEV PLFAPALVSE KTLLRLLKYP DVVQELHFNE DDKKASENFL
YQRSKIADYF ILILQGKVEV EAGKENMKFE SGAFSYYGVM AINTPSAAEL RSPSHMSSLN
RSISLSCHER SDSISSTISG SNTQLSAQAQ YMADFSVRAL GDLQFVKITR EQYQGALMSS
RLDSSPQSPE GGTRKPDSTL SERSEVLEDE TTSLLNQRNS QHSLQHNAV
