CNN_DROME
ID CNN_DROME Reviewed; 1320 AA.
AC P54623; A0A0B4K705; E1JH56; Q5BIF5; Q86NP3; Q8IHE5; Q8ML65; Q9V6P7; Q9V6P8;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2005, sequence version 3.
DT 03-AUG-2022, entry version 169.
DE RecName: Full=Centrosomin;
DE AltName: Full=Protein arrow;
GN Name=cnn; Synonyms=Arr; ORFNames=CG4832;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RC STRAIN=Oregon-R;
RX PubMed=8582295; DOI=10.1242/dev.121.11.3861;
RA Heuer J.G., Li K., Kaufman T.C.;
RT "The Drosophila homeotic target gene centrosomin (cnn) encodes a novel
RT centrosomal protein with leucine zippers and maps to a genomic region
RT required for midgut morphogenesis.";
RL Development 121:3861-3876(1995).
RN [2]
RP SEQUENCE REVISION.
RA Li K., Kaufman T.C.;
RL Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND J), FUNCTION, SUBCELLULAR
RP LOCATION, AND TISSUE SPECIFICITY.
RC TISSUE=Embryo, and Testis;
RX PubMed=9548723; DOI=10.1083/jcb.141.2.455;
RA Li K., Xu E.Y., Cecil J.K., Turner F.R., Megraw T.L., Kaufman T.C.;
RT "Drosophila centrosomin protein is required for male meiosis and assembly
RT of the flagellar axoneme.";
RL J. Cell Biol. 141:455-467(1998).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS A; B AND H).
RC STRAIN=Berkeley; TISSUE=Embryo, and Testis;
RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Champe M.,
RA Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.A.,
RA Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G., Miranda A.,
RA Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., Patel S.,
RA Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., Celniker S.E.;
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM G).
RC STRAIN=Berkeley; TISSUE=Testis;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [8]
RP FUNCTION, SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RX PubMed=8653793; DOI=10.1016/s0092-8674(00)81258-1;
RA Li K., Kaufman T.C.;
RT "The homeotic target gene centrosomin encodes an essential centrosomal
RT component.";
RL Cell 85:585-596(1996).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-545; THR-782; SER-785;
RP SER-874; SER-876; SER-878; SER-1191; SER-1234; SER-1237 AND SER-1239, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- FUNCTION: Core component of the centrosome throughout spermatogenesis.
CC May participate in mitotic spindle assembly and the mechanics of
CC morphogenesis through an interaction with microtubules, either directly
CC or indirectly. Is a target of several homeotic genes.
CC {ECO:0000269|PubMed:8653793, ECO:0000269|PubMed:9548723}.
CC -!- SUBUNIT: Monomer.
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome. Cytoplasm, cytoskeleton, flagellum basal
CC body. Note=Localized to the centrosomes through complete nuclear cycles
CC in mitotic and meiotic cells. Redistributed into the cytoplasm in G2
CC phase cells. In post-meiotic stages, found associated with the basal
CC body of the maturing spermatid.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=J; Synonyms=Embryonic;
CC IsoId=P54623-1; Sequence=Displayed;
CC Name=A; Synonyms=Testis;
CC IsoId=P54623-2; Sequence=VSP_013811, VSP_013813;
CC Name=B;
CC IsoId=P54623-3; Sequence=VSP_013812, VSP_013813;
CC Name=G;
CC IsoId=P54623-4; Sequence=VSP_059602, VSP_059603;
CC Name=H;
CC IsoId=P54623-5; Sequence=VSP_059600, VSP_059601;
CC -!- TISSUE SPECIFICITY: Developing visceral mesoderm of the midgut, the
CC central and peripheral nervous system, and developing gonads. Isoform
CC J: Expressed in ovaries, testis and embryos. Isoform A: Expressed in
CC testis only. {ECO:0000269|PubMed:8582295, ECO:0000269|PubMed:9548723}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
CC {ECO:0000269|PubMed:8653793}.
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DR EMBL; U35621; AAB82065.1; -; mRNA.
DR EMBL; AE013599; AAF58375.1; -; Genomic_DNA.
DR EMBL; AE013599; AAF58376.2; -; Genomic_DNA.
DR EMBL; AE013599; AAM68579.1; -; Genomic_DNA.
DR EMBL; AE013599; ACZ94414.1; -; Genomic_DNA.
DR EMBL; AE013599; AFH08050.1; -; Genomic_DNA.
DR EMBL; BT010053; AAQ22522.1; -; mRNA.
DR EMBL; BT003808; AAO41491.1; -; mRNA.
DR EMBL; BT021269; AAX33417.1; -; mRNA.
DR EMBL; BT001287; AAN71043.1; -; mRNA.
DR PIR; T13347; T13347.
DR RefSeq; NP_001163141.1; NM_001169670.2. [P54623-4]
DR RefSeq; NP_001246294.1; NM_001259365.2. [P54623-3]
DR RefSeq; NP_001246295.1; NM_001259366.2. [P54623-3]
DR RefSeq; NP_001246296.1; NM_001259367.1. [P54623-5]
DR RefSeq; NP_477084.1; NM_057736.6. [P54623-2]
DR RefSeq; NP_725297.1; NM_165990.3. [P54623-3]
DR RefSeq; NP_725298.1; NM_165991.4. [P54623-1]
DR PDB; 5I7C; X-ray; 2.80 A; A/B/C/D=1254-1320.
DR PDB; 5MVW; X-ray; 1.82 A; A/B=1254-1320, C/D=662-716.
DR PDB; 5MW0; X-ray; 2.00 A; A/B=1254-1320, C/D=662-716.
DR PDB; 5MW9; X-ray; 2.20 A; A/B/E/F=1254-1320, C/D/G/H=662-716.
DR PDB; 5MWE; X-ray; 2.02 A; A/B=1254-1320, C/D=662-739.
DR PDBsum; 5I7C; -.
DR PDBsum; 5MVW; -.
DR PDBsum; 5MW0; -.
DR PDBsum; 5MW9; -.
DR PDBsum; 5MWE; -.
DR AlphaFoldDB; P54623; -.
DR SMR; P54623; -.
DR BioGRID; 62251; 106.
DR DIP; DIP-60708N; -.
DR IntAct; P54623; 20.
DR MINT; P54623; -.
DR STRING; 7227.FBpp0301625; -.
DR iPTMnet; P54623; -.
DR PaxDb; P54623; -.
DR PRIDE; P54623; -.
DR DNASU; 36491; -.
DR EnsemblMetazoa; FBtr0087703; FBpp0086822; FBgn0013765. [P54623-2]
DR EnsemblMetazoa; FBtr0087704; FBpp0086823; FBgn0013765. [P54623-3]
DR EnsemblMetazoa; FBtr0301395; FBpp0290609; FBgn0013765. [P54623-4]
DR EnsemblMetazoa; FBtr0306635; FBpp0297590; FBgn0013765. [P54623-5]
DR EnsemblMetazoa; FBtr0309889; FBpp0301623; FBgn0013765. [P54623-1]
DR EnsemblMetazoa; FBtr0309892; FBpp0301626; FBgn0013765. [P54623-3]
DR EnsemblMetazoa; FBtr0309893; FBpp0301627; FBgn0013765. [P54623-3]
DR GeneID; 36491; -.
DR KEGG; dme:Dmel_CG4832; -.
DR CTD; 36491; -.
DR FlyBase; FBgn0013765; cnn.
DR VEuPathDB; VectorBase:FBgn0013765; -.
DR eggNOG; ENOG502QTI7; Eukaryota.
DR InParanoid; P54623; -.
DR PhylomeDB; P54623; -.
DR SignaLink; P54623; -.
DR BioGRID-ORCS; 36491; 0 hits in 3 CRISPR screens.
DR ChiTaRS; arr; fly.
DR GenomeRNAi; 36491; -.
DR PRO; PR:P54623; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0013765; Expressed in egg cell and 36 other tissues.
DR ExpressionAtlas; P54623; baseline and differential.
DR Genevisible; P54623; DM.
DR GO; GO:0005814; C:centriole; IDA:FlyBase.
DR GO; GO:0005813; C:centrosome; IDA:FlyBase.
DR GO; GO:0036064; C:ciliary basal body; IDA:FlyBase.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR GO; GO:0000242; C:pericentriolar material; IDA:FlyBase.
DR GO; GO:0000922; C:spindle pole; IDA:FlyBase.
DR GO; GO:0060090; F:molecular adaptor activity; IBA:GO_Central.
DR GO; GO:0008356; P:asymmetric cell division; IDA:FlyBase.
DR GO; GO:0055059; P:asymmetric neuroblast division; IMP:FlyBase.
DR GO; GO:0007417; P:central nervous system development; IMP:FlyBase.
DR GO; GO:0007099; P:centriole replication; IDA:FlyBase.
DR GO; GO:0007098; P:centrosome cycle; IMP:FlyBase.
DR GO; GO:0040016; P:embryonic cleavage; IMP:FlyBase.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0007494; P:midgut development; IMP:FlyBase.
DR GO; GO:0007052; P:mitotic spindle organization; IMP:FlyBase.
DR GO; GO:0007422; P:peripheral nervous system development; IMP:FlyBase.
DR GO; GO:0008594; P:photoreceptor cell morphogenesis; IMP:FlyBase.
DR GO; GO:0007279; P:pole cell formation; IMP:FlyBase.
DR GO; GO:0090063; P:positive regulation of microtubule nucleation; IBA:GO_Central.
DR GO; GO:0030997; P:regulation of centriole-centriole cohesion; IMP:FlyBase.
DR GO; GO:1903358; P:regulation of Golgi organization; IBA:GO_Central.
DR InterPro; IPR012943; Cnn_1N.
DR Pfam; PF07989; Cnn_1N; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Cell cycle; Cell division;
KW Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton;
KW Developmental protein; Flagellum; Meiosis; Mitosis; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..1320
FT /note="Centrosomin"
FT /id="PRO_0000089974"
FT REGION 20..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 517..554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 810..849
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 863..893
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1220..1249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 97..516
FT /evidence="ECO:0000255"
FT COILED 626..654
FT /evidence="ECO:0000255"
FT COILED 712..983
FT /evidence="ECO:0000255"
FT MOTIF 644..656
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 527..554
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 810..827
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 828..842
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 863..880
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1231..1249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 545
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 782
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 785
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 874
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 876
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 878
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1191
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1234
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1237
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1239
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT VAR_SEQ 1..19
FT /note="MNSNRTSSSHNSRNLKILN -> MDQSKQVLRDYCGDGNGTCASSLKEITLI
FT ETVTSFLEENGAAEIDRRVLRKLAEALSKSIDDTSPGALQDVTMENSY (in
FT isoform A)"
FT /evidence="ECO:0000303|PubMed:8582295,
FT ECO:0000303|PubMed:9548723, ECO:0000303|Ref.6"
FT /id="VSP_013811"
FT VAR_SEQ 1..19
FT /note="MNSNRTSSSHNSRNLKILN -> MAGIFRSTSLNHSSDVPGTPFKRYSLNSN
FT NSTFCTSPGALQDVTMENSY (in isoform B)"
FT /evidence="ECO:0000303|Ref.6"
FT /id="VSP_013812"
FT VAR_SEQ 233..462
FT /note="Missing (in isoform A and isoform B)"
FT /evidence="ECO:0000303|PubMed:8582295,
FT ECO:0000303|PubMed:9548723, ECO:0000303|Ref.6"
FT /id="VSP_013813"
FT VAR_SEQ 362..462
FT /note="RFVWQSGTIVAQEPLPLERQSAAATSNVSVSAVRLSSGPPPDQTYPVNGHDR
FT AKYGLLQLFAAKLDWISAVPLALGHLALKIILLAMRLHSCLQNVHIPLR -> VGITSS
FT LERSGSTSSLHSNFSSISVLCGSQGPSSHKSLCHWKGSQLQQQATYPCPQYVYHQGHHQ
FT TRHTQLMAMTAPSTAFYNYSLPSLTGFRQFLWRWGT (in isoform H)"
FT /id="VSP_059600"
FT VAR_SEQ 463..1320
FT /note="Missing (in isoform H)"
FT /id="VSP_059601"
FT VAR_SEQ 463..480
FT /note="ANRDLGAQLADKICELQE -> VSFELGHSMPLAGILYSI (in isoform
FT G)"
FT /id="VSP_059602"
FT VAR_SEQ 481..1320
FT /note="Missing (in isoform G)"
FT /id="VSP_059603"
FT CONFLICT 177
FT /note="N -> S (in Ref. 6; AAX33417)"
FT /evidence="ECO:0000305"
FT CONFLICT 490
FT /note="R -> S (in Ref. 6; AAX33417)"
FT /evidence="ECO:0000305"
FT CONFLICT 607
FT /note="K -> E (in Ref. 6; AAX33417)"
FT /evidence="ECO:0000305"
FT CONFLICT 951
FT /note="D -> G (in Ref. 6; AAX33417)"
FT /evidence="ECO:0000305"
FT CONFLICT 953
FT /note="H -> Q (in Ref. 1; AAB82065)"
FT /evidence="ECO:0000305"
FT CONFLICT 1011
FT /note="L -> Q (in Ref. 1; AAB82065)"
FT /evidence="ECO:0000305"
FT HELIX 670..679
FT /evidence="ECO:0007829|PDB:5MVW"
FT HELIX 681..687
FT /evidence="ECO:0007829|PDB:5MVW"
FT HELIX 690..713
FT /evidence="ECO:0007829|PDB:5MVW"
FT HELIX 1256..1311
FT /evidence="ECO:0007829|PDB:5MVW"
SQ SEQUENCE 1320 AA; 149521 MW; 34211B865FA6D33B CRC64;
MNSNRTSSSH NSRNLKILNA SFDVPRPPGG GNSPLPSQGR SVRELEEQMS ALRKENFNLK
LRIYFLEEGQ PGARADSSTE SLSKQLIDAK IEIATLRKTV DVKMELLKDA ARAISHHEEL
QRKADIDSQA IIDELQEQIH AYQMAESGGQ PVENIAKTRK MLRLESEVQR LEEELVNIEA
RNVAARNELE FMLAERLESL TACEGKIQEL AIKNSELVER LEKETASAES SNEAIDSLKV
ELEACRKENQ DLVTSIRTLK HDMKRQVRSM KEAANTMDVQ RQSILLLEAT IKRKEKSCGS
MQKNVLNYEA LIAKLNAELE TMRQQNVYFR ELSENLQQKE VRQLDRGVAI VQPMRMTADA
GRFVWQSGTI VAQEPLPLER QSAAATSNVS VSAVRLSSGP PPDQTYPVNG HDRAKYGLLQ
LFAAKLDWIS AVPLALGHLA LKIILLAMRL HSCLQNVHIP LRANRDLGAQ LADKICELQE
AQEKLKERER IHEQACRTIQ KLMQKLSSQE KEIKKLNQEN EQSANKENDC AKTVISPSSS
GRSMSDNEAS SQEMSTNLRV RYELKINEQE EKIKQLQTEV KKKTANLQNL VNKELWEKNR
EVERLTKLLA NQQKTLPQIS EESAGEADLQ QSFTEAEYMR ALERNKLLQR KVDVLFQRLA
DDQQNSAVIG QLRLELQQAR TEVETADKWR LECVDVCSVL TNRLEELAGF LNSLLKHKDV
LGVLAADRRN AMRKAVDRSL DLSKSLNMTL NITATSLADQ SLAQLCNLSE ILYTEGDASH
KTFNSHEELH AATSMAPTVE NLKAENKALK KELEKRRSSE GQRKERRSLP LPSQQFDNQS
ESEAWSEPDR KVSLARIGLD ETSNSLAAPE QAISESESEG RTCATRQDRN RNSERIAQLE
EQIAQKDERM LNVQCQMVEL DNRYKQEQLR CLDITQQLEQ LRAINEALTA DLHAIGSHEE
ERMVELQRQL ELKNQQIDQL KLAHSTLTAD SQITEMELQA LQQQMQEIEQ LHADSVETLQ
SQLQKLKLDA VQQLEEHERL HREALERDWV ALTTYQEQAQ QLLELQRSLD YHQENEKELK
QTLVENELAT RALKKQLDES TLQASKAVME RTKAYNDKLQ LEKRSEELRL QLEALKEEHQ
KLLQKRSNSS DVSQSGYTSE EVAVPMGPPS GQATTCKQAA AAVLGQRVNT SSPDLGIESD
AGRISSVEVS NAQRAMLKTV EMKTEGSASP KAKSEESTSP DSKSNVATGA ATVHDCAKVD
LENAELRRKL IRTKRAFEDT YEKLRMANKA KAQVEKDIKN QILKTHNVLR NVRSNMENEL
