ID   CNO10_BOVIN             Reviewed;         743 AA.
AC   A4IFB6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=CCR4-NOT transcription complex subunit 10;
GN   Name=CNOT10;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Component of the CCR4-NOT complex at least composed of CNOT1,
CC       CNOT2, CNOT3, CNOT8, CNOT9, CNOT10 and TNKS1BP1. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CNOT10 family. {ECO:0000305}.
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DR   EMBL; BC134501; AAI34502.1; -; mRNA.
DR   RefSeq; NP_001077224.1; NM_001083755.1.
DR   AlphaFoldDB; A4IFB6; -.
DR   STRING; 9913.ENSBTAP00000006348; -.
DR   PaxDb; A4IFB6; -.
DR   PRIDE; A4IFB6; -.
DR   Ensembl; ENSBTAT00000006348; ENSBTAP00000006348; ENSBTAG00000004834.
DR   GeneID; 540938; -.
DR   KEGG; bta:540938; -.
DR   CTD; 25904; -.
DR   VEuPathDB; HostDB:ENSBTAG00000004834; -.
DR   VGNC; VGNC:27515; CNOT10.
DR   eggNOG; KOG2471; Eukaryota.
DR   GeneTree; ENSGT00390000001827; -.
DR   HOGENOM; CLU_013100_0_0_1; -.
DR   InParanoid; A4IFB6; -.
DR   OMA; VWCFSKA; -.
DR   OrthoDB; 249353at2759; -.
DR   TreeFam; TF323368; -.
DR   Proteomes; UP000009136; Chromosome 22.
DR   Bgee; ENSBTAG00000004834; Expressed in spermatid and 105 other tissues.
DR   ExpressionAtlas; A4IFB6; baseline.
DR   GO; GO:0030014; C:CCR4-NOT complex; ISS:UniProtKB.
DR   GO; GO:0006402; P:mRNA catabolic process; IBA:GO_Central.
DR   GO; GO:0017148; P:negative regulation of translation; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR039740; CNOT10.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR12979; PTHR12979; 1.
DR   SMART; SM00028; TPR; 4.
DR   SUPFAM; SSF48452; SSF48452; 3.
PE   2: Evidence at transcript level;
KW   Acetylation; Coiled coil; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H9A5"
FT   CHAIN           2..743
FT                   /note="CCR4-NOT transcription complex subunit 10"
FT                   /id="PRO_0000314578"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          183..204
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          477..520
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          602..634
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          77..107
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        183..203
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        482..502
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H9A5"
SQ   SEQUENCE   743 AA;  81984 MW;  9A42AB408F6EA823 CRC64;
     MAADKPADQG AEKHEGPGPS SGITDQEKEL STSAFQAFTA GNYDVCLQHL TCLQDINKDD
     YKIILNTAVA EFFKSNQTTT DSLRQTLNQL KNQVHSAVEE MDGLDDVENS MLYYNQAVIL
     YHLRQYTEAI SVGEKLYQFI EPFEEKFAQA VCFLLVDLYI LTYQAEKALH LLAVLEKMIS
     QGNNNKNGKN ETGNNTNKDG SNHKAESGAL IEAAKSKIHQ YKVRAYIQMK SLKACKREIK
     SVMNTAGNSA PSLFLKSNFE YLRGNYRKAV KLLNSSNIAE HPGFMKTGEC LRCMFWNNLG
     CIHFAMSKHN LGIFYFKKAL QENDNVCAQL SAGSTDPGKK FSGRPMCTLL TNKRYELLYN
     CGIQLLHIGR PLAAFECLIE AVQVYHANPR LWLRLAECCI AANKGTSEQE TKGLPSKKGI
     VQSIVGQGYH RKIVLASQSI QNTVYNDGQS SAIPVASMEF AAICLRNALL LLPEDQQDPK
     QENGSKNSNQ LGGNAESGES SDACSSKSHD GDKCIPAPPS SPLRKQELEN LKCSILACSA
     YVALALGDNL MALNHADKLL QQPKLSGSLK FLGHLYAAEA LISLDRISDA ITHLNPENVT
     DVSLGISSNE QDQGSDKGEN EAMESSGKRA PQCYPSSVSS ARTVMLFNLG SAYCLRSEYD
     KARKCLHQAA SMIHPKEVPP EAILLAVYLE LQNGNTQLAL QIIKRNQLLP AVKTLSEMRK
     KPVFQPVHPI QPIQMPAFTV QRK