ID   CNO10_CHICK             Reviewed;         744 AA.
AC   Q5ZIW2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=CCR4-NOT transcription complex subunit 10;
GN   Name=CNOT10; ORFNames=RCJMB04_23c21;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Component of the CCR4-NOT complex which is one of the major
CC       cellular mRNA deadenylases and is linked to various cellular processes
CC       including bulk mRNA degradation, miRNA-mediated repression,
CC       translational repression during translational initiation and general
CC       transcription regulation. Additional complex functions may be a
CC       consequence of its influence on mRNA expression. Is not required for
CC       association of CNOT7 to the CCR4-NOT complex (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the CCR4-NOT complex. CNOT10 and CNOT11 form a
CC       subcomplex docked to the CNOT1 scaffold (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CNOT10 family. {ECO:0000305}.
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DR   EMBL; AJ720672; CAG32331.1; -; mRNA.
DR   RefSeq; NP_001006364.1; NM_001006364.2.
DR   AlphaFoldDB; Q5ZIW2; -.
DR   STRING; 9031.ENSGALP00000018708; -.
DR   PaxDb; Q5ZIW2; -.
DR   Ensembl; ENSGALT00000018731; ENSGALP00000018708; ENSGALG00000011494.
DR   GeneID; 420669; -.
DR   KEGG; gga:420669; -.
DR   CTD; 25904; -.
DR   VEuPathDB; HostDB:geneid_420669; -.
DR   eggNOG; KOG2471; Eukaryota.
DR   GeneTree; ENSGT00390000001827; -.
DR   HOGENOM; CLU_013100_0_0_1; -.
DR   InParanoid; Q5ZIW2; -.
DR   OMA; VWCFSKA; -.
DR   OrthoDB; 249353at2759; -.
DR   PhylomeDB; Q5ZIW2; -.
DR   TreeFam; TF323368; -.
DR   Reactome; R-GGA-429947; Deadenylation of mRNA.
DR   Reactome; R-GGA-6804115; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.
DR   PRO; PR:Q5ZIW2; -.
DR   Proteomes; UP000000539; Chromosome 2.
DR   Bgee; ENSGALG00000011494; Expressed in testis and 12 other tissues.
DR   ExpressionAtlas; Q5ZIW2; baseline and differential.
DR   GO; GO:0030014; C:CCR4-NOT complex; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
DR   GO; GO:0006402; P:mRNA catabolic process; IBA:GO_Central.
DR   GO; GO:0017148; P:negative regulation of translation; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR039740; CNOT10.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR12979; PTHR12979; 1.
DR   SMART; SM00028; TPR; 5.
DR   SUPFAM; SSF48452; SSF48452; 2.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Nucleus; Reference proteome;
KW   RNA-mediated gene silencing; Transcription; Transcription regulation;
KW   Translation regulation.
FT   CHAIN           1..744
FT                   /note="CCR4-NOT transcription complex subunit 10"
FT                   /id="PRO_0000314583"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          182..204
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          476..520
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          602..634
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          72..106
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        482..502
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   744 AA;  82122 MW;  54C44585E0D247D1 CRC64;
     MAADKAADQG AEKHDGAGTS GITDQEKELS SSALQAFLAG NYDACLQHLN TLQDINKDDY
     KITLNTAVAE FCKSNQTTTD NLRQTLNQLK NQVHSAVEEM DGLDDVENSM LYYNQAVILY
     HLRQYTEAIS VGEKLYQFIE PFEEKFAQAV CFLLVDLYLL TYQAEKALHL LAVLEKMISQ
     GNNNSKNGKN ESGNNTNKDS SNQKAESGAL IEVAKSKIHQ YKVRAYIQMK SLKACKREIK
     SVMNTAGNSA PSLFLKSNFE YLRGNYRKAV KLLNSANIAE HPGFMKTGEC LRCMFWNNLG
     CIHFAMGKHN LGIFYFKKAL QENDNACAQL GTGSSDPGKK FSGRPMCTLL TNKRYELLYN
     CGIQLLHIGR PLAAFECLIE AVQVYHSNPR LWLRIAECCI AANKGTSEQE TKGLPSKKGI
     VQSIVGQGYH RKIVLASQSI QNVVYNDGQS SAIPVASMEF AAICLRNALL LLPEDQQEPK
     QENGSKPNNQ LGGNTENSES SEACSNKSHE GDKFIAAPPS SPLKKQELEN LRCSILACSA
     YVALALGDNL MALNHADKLL QQPKLSGSLK FLGHLYAAEA LISLDRISDA ITHLNPENVT
     DVSLGISSNE QDQGSDKGEN EAMESSGKQT PQCYPSSVTS ARTMMLFNLG SAYCLRSEYD
     KARKCLHQAA SLIHPKEIPP EAILLAVYLE LQNGNTQLAL QIIKRNQLLP SVKTLSDMRK
     KPVFQPVHSL QPIQMPTFTA VQRK