ID   CNO10_DANRE             Reviewed;         624 AA.
AC   Q08CL8; Q5BLH2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=CCR4-NOT transcription complex subunit 10;
GN   Name=cnot10; ORFNames=im:7139356, zgc:152939;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the CCR4-NOT complex which is one of the major
CC       cellular mRNA deadenylases and is linked to various cellular processes
CC       including bulk mRNA degradation, miRNA-mediated repression,
CC       translational repression during translational initiation and general
CC       transcription regulation. Additional complex functions may be a
CC       consequence of its influence on mRNA expression. Is not required for
CC       association of CNOT7 to the CCR4-NOT complex (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the CCR4-NOT complex. cnot10 and cnot11 form a
CC       subcomplex docked to the cnot1 scaffold (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CNOT10 family. {ECO:0000305}.
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DR   EMBL; BC090438; AAH90438.1; -; mRNA.
DR   EMBL; BC124182; AAI24183.1; -; mRNA.
DR   RefSeq; NP_001071000.1; NM_001077532.2.
DR   AlphaFoldDB; Q08CL8; -.
DR   PaxDb; Q08CL8; -.
DR   GeneID; 449918; -.
DR   KEGG; dre:449918; -.
DR   CTD; 25904; -.
DR   ZFIN; ZDB-GENE-060929-368; cnot10.
DR   eggNOG; KOG2471; Eukaryota.
DR   InParanoid; Q08CL8; -.
DR   OrthoDB; 249353at2759; -.
DR   PhylomeDB; Q08CL8; -.
DR   Reactome; R-DRE-429947; Deadenylation of mRNA.
DR   Reactome; R-DRE-6804115; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.
DR   PRO; PR:Q08CL8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0030014; C:CCR4-NOT complex; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
DR   GO; GO:0006402; P:mRNA catabolic process; IBA:GO_Central.
DR   GO; GO:0017148; P:negative regulation of translation; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR039740; CNOT10.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR12979; PTHR12979; 2.
DR   SMART; SM00028; TPR; 4.
DR   SUPFAM; SSF48452; SSF48452; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; RNA-mediated gene silencing;
KW   Transcription; Transcription regulation; Translation regulation.
FT   CHAIN           1..624
FT                   /note="CCR4-NOT transcription complex subunit 10"
FT                   /id="PRO_0000314584"
FT   REGION          351..397
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          480..507
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          589..624
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        358..383
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        598..624
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        389..391
FT                   /note="KFI -> GFT (in Ref. 1; AAH90438)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        462
FT                   /note="G -> R (in Ref. 1; AAH90438)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   624 AA;  68257 MW;  57854C72445D0CC0 CRC64;
     MKHDIASSPG MSDLEKEVAT NAFEAFKTGS YDESLKYLDN LQELNKEDYK ITMNKTVTEF
     YKSGQTTSST NKESAALKAE FTAMIEAAKS KMHQYKVRAY IQMKSLKACK REIKSVMNTS
     GNSAPSLFLK SNFEYLRGNY RKAVKLLNSS NIAEHPGPLK TGECVRCMFW NNLGCIHFAM
     GKHNLGLFYF KKALQENDHT CAQIGDGSNA QASKKFSGIP MCALLANKRY ELLYNCGIQL
     LHIGRPLAAF ECLMEAVQVY HSNPRLWLRL AECCITANKG SSEQETKGLP SKKGIVQAVV
     GQGYHRKIVL ASQSTQNTIY SEAQSAAIPV ASMEFAAICL RNALLLLPEH QQHDSKPDNG
     SKSYSQSGGT ESGSETSDAC SGKTQEGDKF IPAAPSSPLR KQEVENLRCS ILACSAYVAL
     ALGDNLMALN HAEKLLHQAK LSGSLKFLGH LYAAEALISL DGISDAIAHL NPENVTDVSL
     GVSSSEQDQG SDKGDLEPVE SSGKQTPLCY PSSVSSARAT MLFNLGSAYC LRSEYEKARK
     CLHQAASMVN TKEIPPEAIL LGVYLELQNG NTQLALQIIK RNQLLPSVKP GSSPDFRKKP
     LSFQSTQPVQ PIQTPSSFTQ VQRK