CNO10_HUMAN
ID CNO10_HUMAN Reviewed; 744 AA.
AC Q9H9A5; B7Z7L1; F8WAF2; Q9BU30; Q9H5J7; Q9H8X1; Q9H9W0; Q9HAH3; Q9UFJ2;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 181.
DE RecName: Full=CCR4-NOT transcription complex subunit 10;
GN Name=CNOT10;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 5 AND 6), NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 85-744 (ISOFORM 4), AND VARIANT SER-348.
RC TISSUE=Embryo, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), AND VARIANT
RP SER-736.
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 482-744 (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [6]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [7]
RP IDENTIFICATION IN THE CCR4-NOT COMPLEX, AND COMPOSITION OF THE CCR4-NOT
RP COMPLEX.
RX PubMed=19558367; DOI=10.1042/bj20090500;
RA Lau N.C., Kolkman A., van Schaik F.M., Mulder K.W., Pijnappel W.W.,
RA Heck A.J., Timmers H.T.;
RT "Human Ccr4-Not complexes contain variable deadenylase subunits.";
RL Biochem. J. 422:443-453(2009).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [9]
RP IDENTIFICATION IN THE CCR4-NOT COMPLEX.
RX PubMed=23232451; DOI=10.4161/rna.23065;
RA Mauxion F., Preve B., Seraphin B.;
RT "C2ORF29/CNOT11 and CNOT10 form a new module of the CCR4-NOT complex.";
RL RNA Biol. 10:267-276(2013).
RN [10]
RP FUNCTION.
RX PubMed=23221646; DOI=10.1093/nar/gks1133;
RA Farber V., Erben E., Sharma S., Stoecklin G., Clayton C.;
RT "Trypanosome CNOT10 is essential for the integrity of the NOT deadenylase
RT complex and for degradation of many mRNAs.";
RL Nucleic Acids Res. 41:1211-1222(2013).
RN [11]
RP INTERACTION WITH CNOT11.
RX PubMed=23303381; DOI=10.4161/rna.23018;
RA Bawankar P., Loh B., Wohlbold L., Schmidt S., Izaurralde E.;
RT "NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex
RT that docks onto the NOT1 N-terminal domain.";
RL RNA Biol. 10:228-244(2013).
RN [12]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- FUNCTION: Component of the CCR4-NOT complex which is one of the major
CC cellular mRNA deadenylases and is linked to various cellular processes
CC including bulk mRNA degradation, miRNA-mediated repression,
CC translational repression during translational initiation and general
CC transcription regulation. Additional complex functions may be a
CC consequence of its influence on mRNA expression. Is not required for
CC association of CNOT7 to the CCR4-NOT complex.
CC {ECO:0000269|PubMed:23221646}.
CC -!- SUBUNIT: Component of the CCR4-NOT complex; distinct complexes seem to
CC exist that differ in the participation of probably mutually exclusive
CC catalytic subunits. CNOT10 and CNOT11 form a subcomplex docked to the
CC CNOT1 scaffold. {ECO:0000269|PubMed:19558367,
CC ECO:0000269|PubMed:23232451}.
CC -!- INTERACTION:
CC Q9H9A5; Q9UKZ1: CNOT11; NbExp=4; IntAct=EBI-1054261, EBI-2562014;
CC Q9H9A5; P42858: HTT; NbExp=4; IntAct=EBI-1054261, EBI-466029;
CC Q9H9A5; Q9HCJ0: TNRC6C; NbExp=10; IntAct=EBI-1054261, EBI-6507625;
CC Q9H9A5-3; P42858: HTT; NbExp=3; IntAct=EBI-25957177, EBI-466029;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1;
CC IsoId=Q9H9A5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9H9A5-2; Sequence=VSP_030312;
CC Name=3;
CC IsoId=Q9H9A5-3; Sequence=VSP_030313;
CC Name=4;
CC IsoId=Q9H9A5-4; Sequence=VSP_030313, VSP_030314;
CC Name=5;
CC IsoId=Q9H9A5-5; Sequence=VSP_030311;
CC Name=6;
CC IsoId=Q9H9A5-6; Sequence=VSP_045557;
CC -!- SIMILARITY: Belongs to the CNOT10 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB13876.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK021695; BAB13876.1; ALT_INIT; mRNA.
DR EMBL; AK022576; BAB14108.1; -; mRNA.
DR EMBL; AK022952; BAB14327.1; -; mRNA.
DR EMBL; AK023227; BAB14478.1; -; mRNA.
DR EMBL; AK027026; BAB15629.1; -; mRNA.
DR EMBL; AK302196; BAH13647.1; -; mRNA.
DR EMBL; AC138972; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC139452; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471055; EAW64435.1; -; Genomic_DNA.
DR EMBL; BC002928; AAH02928.1; -; mRNA.
DR EMBL; BC002931; AAH02931.1; -; mRNA.
DR EMBL; AL117639; CAB56027.2; -; mRNA.
DR CCDS; CCDS2655.1; -. [Q9H9A5-1]
DR CCDS; CCDS58821.1; -. [Q9H9A5-3]
DR CCDS; CCDS58822.1; -. [Q9H9A5-6]
DR RefSeq; NP_001243670.1; NM_001256741.1. [Q9H9A5-3]
DR RefSeq; NP_001243671.1; NM_001256742.1. [Q9H9A5-6]
DR RefSeq; NP_056257.1; NM_015442.2. [Q9H9A5-1]
DR AlphaFoldDB; Q9H9A5; -.
DR BioGRID; 117411; 123.
DR ComplexPortal; CPX-2522; CCR4-NOT mRNA deadenylase complex, CNOT6L-CNOT7 variant.
DR ComplexPortal; CPX-2535; CCR4-NOT mRNA deadenylase complex, CNOT6L-CNOT8 variant.
DR ComplexPortal; CPX-2849; CCR4-NOT mRNA deadenylase complex, CNOT6-CNOT8 variant.
DR ComplexPortal; CPX-707; CCR4-NOT mRNA deadenylase complex, CNOT6-CNOT7 variant.
DR CORUM; Q9H9A5; -.
DR DIP; DIP-46839N; -.
DR IntAct; Q9H9A5; 47.
DR MINT; Q9H9A5; -.
DR STRING; 9606.ENSP00000399862; -.
DR ChEMBL; CHEMBL4105878; -.
DR GlyGen; Q9H9A5; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9H9A5; -.
DR PhosphoSitePlus; Q9H9A5; -.
DR BioMuta; CNOT10; -.
DR DMDM; 74733982; -.
DR EPD; Q9H9A5; -.
DR jPOST; Q9H9A5; -.
DR MassIVE; Q9H9A5; -.
DR MaxQB; Q9H9A5; -.
DR PaxDb; Q9H9A5; -.
DR PeptideAtlas; Q9H9A5; -.
DR PRIDE; Q9H9A5; -.
DR ProteomicsDB; 30485; -.
DR ProteomicsDB; 81300; -. [Q9H9A5-1]
DR ProteomicsDB; 81301; -. [Q9H9A5-2]
DR ProteomicsDB; 81302; -. [Q9H9A5-3]
DR ProteomicsDB; 81303; -. [Q9H9A5-4]
DR ProteomicsDB; 81304; -. [Q9H9A5-5]
DR Antibodypedia; 27780; 88 antibodies from 22 providers.
DR DNASU; 25904; -.
DR Ensembl; ENST00000328834.10; ENSP00000330060.5; ENSG00000182973.20. [Q9H9A5-1]
DR Ensembl; ENST00000331889.10; ENSP00000329376.6; ENSG00000182973.20. [Q9H9A5-3]
DR Ensembl; ENST00000454516.7; ENSP00000399862.2; ENSG00000182973.20. [Q9H9A5-6]
DR GeneID; 25904; -.
DR KEGG; hsa:25904; -.
DR MANE-Select; ENST00000328834.10; ENSP00000330060.5; NM_015442.3; NP_056257.1.
DR UCSC; uc003cfc.2; human. [Q9H9A5-1]
DR CTD; 25904; -.
DR GeneCards; CNOT10; -.
DR HGNC; HGNC:23817; CNOT10.
DR HPA; ENSG00000182973; Low tissue specificity.
DR neXtProt; NX_Q9H9A5; -.
DR PharmGKB; PA134862503; -.
DR VEuPathDB; HostDB:ENSG00000182973; -.
DR eggNOG; KOG2471; Eukaryota.
DR GeneTree; ENSGT00390000001827; -.
DR HOGENOM; CLU_013100_0_0_1; -.
DR InParanoid; Q9H9A5; -.
DR OMA; VWCFSKA; -.
DR OrthoDB; 249353at2759; -.
DR PhylomeDB; Q9H9A5; -.
DR TreeFam; TF323368; -.
DR PathwayCommons; Q9H9A5; -.
DR Reactome; R-HSA-429947; Deadenylation of mRNA.
DR Reactome; R-HSA-6804115; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.
DR SignaLink; Q9H9A5; -.
DR SIGNOR; Q9H9A5; -.
DR BioGRID-ORCS; 25904; 43 hits in 1089 CRISPR screens.
DR ChiTaRS; CNOT10; human.
DR GenomeRNAi; 25904; -.
DR Pharos; Q9H9A5; Tdark.
DR PRO; PR:Q9H9A5; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q9H9A5; protein.
DR Bgee; ENSG00000182973; Expressed in right testis and 132 other tissues.
DR ExpressionAtlas; Q9H9A5; baseline and differential.
DR Genevisible; Q9H9A5; HS.
DR GO; GO:0030014; C:CCR4-NOT complex; IDA:UniProtKB.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0016020; C:membrane; HDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
DR GO; GO:0006402; P:mRNA catabolic process; IBA:GO_Central.
DR GO; GO:0017148; P:negative regulation of translation; IBA:GO_Central.
DR GO; GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; IC:ComplexPortal.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR039740; CNOT10.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR12979; PTHR12979; 1.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF48452; SSF48452; 3.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Coiled coil; Cytoplasm; Nucleus;
KW Reference proteome; RNA-mediated gene silencing; Transcription;
KW Transcription regulation; Translation regulation.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:19413330"
FT CHAIN 2..744
FT /note="CCR4-NOT transcription complex subunit 10"
FT /id="PRO_0000314579"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 477..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 602..634
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 74..107
FT /evidence="ECO:0000255"
FT COMPBIAS 183..203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 482..502
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0007744|PubMed:19413330"
FT VAR_SEQ 1..293
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_030311"
FT VAR_SEQ 1..7
FT /note="MAADKPA -> MKSIGVKTVKVCGSKSSVRIEGQPCSLGQSRRKVKLMGERS
FT YTLSIGNGDYFWANKEMLWDYVQTLS (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_045557"
FT VAR_SEQ 144
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_030312"
FT VAR_SEQ 505..532
FT /note="SSKSHDGDKFIPAPPSSPLRKQELENLK -> R (in isoform 3 and
FT isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_030313"
FT VAR_SEQ 556..577
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_030314"
FT VARIANT 348
FT /note="T -> S (in dbSNP:rs11558687)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_053982"
FT VARIANT 736
FT /note="P -> S (in dbSNP:rs17849684)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_037957"
FT CONFLICT 5
FT /note="K -> R (in Ref. 1; BAB14108)"
FT /evidence="ECO:0000305"
FT CONFLICT 52
FT /note="C -> R (in Ref. 1; BAB14478)"
FT /evidence="ECO:0000305"
FT CONFLICT 270
FT /note="V -> M (in Ref. 1; BAB13876)"
FT /evidence="ECO:0000305"
FT CONFLICT 478
FT /note="D -> G (in Ref. 1; BAB14108)"
FT /evidence="ECO:0000305"
FT CONFLICT 509
FT /note="H -> Y (in Ref. 1; BAB14108)"
FT /evidence="ECO:0000305"
FT CONFLICT 518
FT /note="P -> L (in Ref. 1; BAH13647)"
FT /evidence="ECO:0000305"
FT CONFLICT 622
FT /note="A -> T (in Ref. 1; BAB14478)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 744 AA; 82310 MW; BA1984B71F0A1E7A CRC64;
MAADKPADQG AEKHEGTGQS SGITDQEKEL STNAFQAFTS GNYDACLQHL ACLQDINKDD
YKIILNTAVA EFFKSNQTTT DNLRQTLNQL KNQVHSAVEE MDGLDDVENS MLYYNQAVIL
YHLRQYTEAI SVGEKLYQFI EPFEEKFAQA VCFLLVDLYI LTYQAEKALH LLAVLEKMIS
QGNNNKNGKN ETGNNNNKDG SNHKAESGAL IEAAKSKIHQ YKVRAYIQMK SLKACKREIK
SVMNTAGNSA PSLFLKSNFE YLRGNYRKAV KLLNSSNIAE HPGFMKTGEC LRCMFWNNLG
CIHFAMSKHN LGIFYFKKAL QENDNVCAQL SAGSTDPGKK FSGRPMCTLL TNKRYELLYN
CGIQLLHIGR PLAAFECLIE AVQVYHANPR LWLRLAECCI AANKGTSEQE TKGLPSKKGI
VQSIVGQGYH RKIVLASQSI QNTVYNDGQS SAIPVASMEF AAICLRNALL LLPEEQQDPK
QENGAKNSNQ LGGNTESSES SETCSSKSHD GDKFIPAPPS SPLRKQELEN LKCSILACSA
YVALALGDNL MALNHADKLL QQPKLSGSLK FLGHLYAAEA LISLDRISDA ITHLNPENVT
DVSLGISSNE QDQGSDKGEN EAMESSGKRA PQCYPSSVNS ARTVMLFNLG SAYCLRSEYD
KARKCLHQAA SMIHPKEVPP EAILLAVYLE LQNGNTQLAL QIIKRNQLLP AVKTHSEVRK
KPVFQPVHPI QPIQMPAFTT VQRK
