CNO10_MOUSE
ID CNO10_MOUSE Reviewed; 744 AA.
AC Q8BH15; Q05CH8; Q3TSS4; Q3UDS5; Q80VN2; Q8CI74;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=CCR4-NOT transcription complex subunit 10;
GN Name=Cnot10;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 1-719 (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Bone marrow, Medulla oblongata, and Skin;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 4 AND 6).
RC STRAIN=FVB/N, and FVB/N-3; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Liver, Lung, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Component of the CCR4-NOT complex which is one of the major
CC cellular mRNA deadenylases and is linked to various cellular processes
CC including bulk mRNA degradation, miRNA-mediated repression,
CC translational repression during translational initiation and general
CC transcription regulation. Additional complex functions may be a
CC consequence of its influence on mRNA expression. Is not required for
CC association of CNOT7 to the CCR4-NOT complex (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of the CCR4-NOT complex; distinct complexes seem to
CC exist that differ in the participation of probably mutually exclusive
CC catalytic subunits. CNOT10 and CNOT11 form a subcomplex docked to the
CC CNOT1 scaffold (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1;
CC IsoId=Q8BH15-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BH15-2; Sequence=VSP_030318;
CC Name=3;
CC IsoId=Q8BH15-3; Sequence=VSP_030320;
CC Name=4;
CC IsoId=Q8BH15-4; Sequence=VSP_030319;
CC Name=5;
CC IsoId=Q8BH15-5; Sequence=VSP_030316, VSP_030317;
CC Name=6;
CC IsoId=Q8BH15-6; Sequence=VSP_030315;
CC -!- SIMILARITY: Belongs to the CNOT10 family. {ECO:0000305}.
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DR EMBL; AK029103; BAC26299.1; -; mRNA.
DR EMBL; AK149944; BAE29186.1; -; mRNA.
DR EMBL; AK161842; BAE36601.1; -; mRNA.
DR EMBL; BC025554; AAH25554.1; -; mRNA.
DR EMBL; BC036179; AAH36179.1; -; mRNA.
DR EMBL; BC039183; AAH39183.1; -; mRNA.
DR EMBL; BC047204; AAH47204.1; -; mRNA.
DR CCDS; CCDS40794.1; -. [Q8BH15-1]
DR RefSeq; NP_705813.2; NM_153585.5. [Q8BH15-1]
DR RefSeq; XP_006512462.1; XM_006512399.3. [Q8BH15-2]
DR AlphaFoldDB; Q8BH15; -.
DR BioGRID; 219688; 1.
DR IntAct; Q8BH15; 1.
DR STRING; 10090.ENSMUSP00000064840; -.
DR iPTMnet; Q8BH15; -.
DR PhosphoSitePlus; Q8BH15; -.
DR EPD; Q8BH15; -.
DR MaxQB; Q8BH15; -.
DR PaxDb; Q8BH15; -.
DR PeptideAtlas; Q8BH15; -.
DR PRIDE; Q8BH15; -.
DR ProteomicsDB; 285513; -. [Q8BH15-1]
DR ProteomicsDB; 285514; -. [Q8BH15-2]
DR ProteomicsDB; 285515; -. [Q8BH15-3]
DR ProteomicsDB; 285516; -. [Q8BH15-4]
DR ProteomicsDB; 285517; -. [Q8BH15-5]
DR ProteomicsDB; 285518; -. [Q8BH15-6]
DR Antibodypedia; 27780; 88 antibodies from 22 providers.
DR Ensembl; ENSMUST00000070117; ENSMUSP00000064840; ENSMUSG00000056167. [Q8BH15-1]
DR GeneID; 78893; -.
DR KEGG; mmu:78893; -.
DR UCSC; uc009rxq.2; mouse. [Q8BH15-1]
DR UCSC; uc009rxr.2; mouse. [Q8BH15-2]
DR UCSC; uc009rxv.2; mouse. [Q8BH15-5]
DR CTD; 25904; -.
DR MGI; MGI:1926143; Cnot10.
DR VEuPathDB; HostDB:ENSMUSG00000056167; -.
DR eggNOG; KOG2471; Eukaryota.
DR GeneTree; ENSGT00390000001827; -.
DR HOGENOM; CLU_013100_0_0_1; -.
DR InParanoid; Q8BH15; -.
DR OMA; VWCFSKA; -.
DR OrthoDB; 249353at2759; -.
DR PhylomeDB; Q8BH15; -.
DR TreeFam; TF323368; -.
DR Reactome; R-MMU-429947; Deadenylation of mRNA.
DR Reactome; R-MMU-6804115; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.
DR BioGRID-ORCS; 78893; 23 hits in 74 CRISPR screens.
DR ChiTaRS; Cnot10; mouse.
DR PRO; PR:Q8BH15; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q8BH15; protein.
DR Bgee; ENSMUSG00000056167; Expressed in floor plate of midbrain and 225 other tissues.
DR ExpressionAtlas; Q8BH15; baseline and differential.
DR Genevisible; Q8BH15; MM.
DR GO; GO:0030014; C:CCR4-NOT complex; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
DR GO; GO:0006402; P:mRNA catabolic process; IBA:GO_Central.
DR GO; GO:0017148; P:negative regulation of translation; IBA:GO_Central.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR039740; CNOT10.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR12979; PTHR12979; 1.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF48452; SSF48452; 2.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Coiled coil; Cytoplasm; Nucleus;
KW Reference proteome; RNA-mediated gene silencing; Transcription;
KW Transcription regulation; Translation regulation.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q9H9A5"
FT CHAIN 2..744
FT /note="CCR4-NOT transcription complex subunit 10"
FT /id="PRO_0000314581"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 182..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 475..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 602..634
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 73..107
FT /evidence="ECO:0000255"
FT COMPBIAS 183..203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 482..502
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q9H9A5"
FT VAR_SEQ 1..644
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_030315"
FT VAR_SEQ 288..302
FT /note="GECLRCMFWNNLGCI -> AQFGDFLLQEGSAGK (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_030316"
FT VAR_SEQ 303..744
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_030317"
FT VAR_SEQ 505
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_030318"
FT VAR_SEQ 533..744
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_030319"
FT VAR_SEQ 615..744
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_030320"
SQ SEQUENCE 744 AA; 81818 MW; 598C842BD70BC819 CRC64;
MAADKPADQG AEKHEGAGQS SGVTDQEKEL SASALQAFTS GNYDACLQHL ACLQDINKDD
YKIILNTAVA EFFKNNQTTT DNLRQTLNQL KNQVHSAVEE MDGLDDVENS MLYYNQAVIL
YHLRQYTEAI SVGEKLYQFI EPFEEKFAQA VCFLLVDLYI LTHQAEKALH LLAVLEKMIS
QGSGGKNGKN ETGNNSSKDG SNPKAESAAL IEAAKSKIHQ YKVRGYIQMK SLKACKREIK
SVMNTAGNSA PSLFLKSNFE YLRGNYRKAV KLLNSSNIAE HPGFMKTGEC LRCMFWNNLG
CIHFAMSKHN LGIFYFKKAL QENDNVCAQL SAGGTDPGKK FSGRPMCTLL TNKRYELLYN
CGIQLLHVGR PLAAFECLIE AVQVYHANPR LWLRLAECCI AANKGTSEQE TKGLPTKKGI
VQSIVGQGYH RKIVLASQSI QNTVYNDGQS SAIPVASVEF AAICLRNALL LLPEEQQDPK
QENGSKSSSQ LGGNTESSES SETCSSKSHD GDKFIPAPPS SPLRKQELEN LKCSILACSA
YVALALGDNL MALNHADQLL QQPKLSGSLK FLGHLYAAEA LISLDRISDA ITHLNPENVT
DVSLGISSNE QDQGSDKGEN EAMESSGKRA PQCYPSSVNS ARTVMLFNLG SAYCLRSEYD
KARKCLHQAA SMIHPKEVPP EAILLAVYLE LQNGNTQLAL QMIKRNQLLP AVKAHSDVRK
KTVFQPVHPI QPIQMPAFTT VQRK
