ID   CNO10_RAT               Reviewed;         744 AA.
AC   Q5XIA4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=CCR4-NOT transcription complex subunit 10;
GN   Name=Cnot10;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Component of the CCR4-NOT complex which is one of the major
CC       cellular mRNA deadenylases and is linked to various cellular processes
CC       including bulk mRNA degradation, miRNA-mediated repression,
CC       translational repression during translational initiation and general
CC       transcription regulation. Additional complex functions may be a
CC       consequence of its influence on mRNA expression. Is not required for
CC       association of CNOT7 to the CCR4-NOT complex (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the CCR4-NOT complex; distinct complexes seem to
CC       exist that differ in the participation of probably mutually exclusive
CC       catalytic subunits. CNOT10 and CNOT11 form a subcomplex docked to the
CC       CNOT1 scaffold (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CNOT10 family. {ECO:0000305}.
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DR   EMBL; BC083782; AAH83782.1; -; mRNA.
DR   RefSeq; NP_001007004.1; NM_001007003.1.
DR   AlphaFoldDB; Q5XIA4; -.
DR   STRING; 10116.ENSRNOP00000013817; -.
DR   PhosphoSitePlus; Q5XIA4; -.
DR   jPOST; Q5XIA4; -.
DR   PaxDb; Q5XIA4; -.
DR   PRIDE; Q5XIA4; -.
DR   GeneID; 316034; -.
DR   KEGG; rno:316034; -.
DR   UCSC; RGD:1359219; rat.
DR   CTD; 25904; -.
DR   RGD; 1359219; Cnot10.
DR   eggNOG; KOG2471; Eukaryota.
DR   InParanoid; Q5XIA4; -.
DR   OrthoDB; 249353at2759; -.
DR   PhylomeDB; Q5XIA4; -.
DR   TreeFam; TF323368; -.
DR   Reactome; R-RNO-429947; Deadenylation of mRNA.
DR   Reactome; R-RNO-6804115; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.
DR   PRO; PR:Q5XIA4; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0030014; C:CCR4-NOT complex; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
DR   GO; GO:0006402; P:mRNA catabolic process; IBA:GO_Central.
DR   GO; GO:0017148; P:negative regulation of translation; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR039740; CNOT10.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR12979; PTHR12979; 1.
DR   SMART; SM00028; TPR; 4.
DR   SUPFAM; SSF48452; SSF48452; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Nucleus; Reference proteome;
KW   RNA-mediated gene silencing; Transcription; Transcription regulation;
KW   Translation regulation.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H9A5"
FT   CHAIN           2..744
FT                   /note="CCR4-NOT transcription complex subunit 10"
FT                   /id="PRO_0000314582"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          183..204
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          475..522
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          602..632
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        183..203
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        482..502
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H9A5"
SQ   SEQUENCE   744 AA;  81819 MW;  3486682DB9C33F96 CRC64;
     MAADKPADQG AEKHEGAGQS SGVTDQEKEL STSAFQAFTS GNYDACLQHL ACLQDINKDD
     YKIILNTAVA EFFKNNQTTT DNLRQTLNQL KNQVHSAVEE MDGLDDVENS MLYYNQAVIL
     YHLRQHTEAI AVGEKLYQFI EPFEEKFAQA VCFLLVDLYI LTHQAEKALH LLAVLEKMIS
     QGSGNKNGKS ETGNNSSKDG SNPKAESAAL IEAAKSKIHQ YKVRGYIQMK SLKACKREIK
     SVMNTAGNSA PSLFLKSNFE YLRGNYRKAV KLLNSSNIAE HPGFMKTGEC LRCMFWNNLG
     CIHFAMSKHN LGIFYFKKAL QENDNVCAQL SAGNTDPGKK FSGRPMCTLL ANKRYELLYN
     CGIQLLHVGR PLAAFECLVE AVQVYHANPR LWLRLAECCI AANKGTSEQE TKGLPTKKGI
     VQSIVGQGYH RKIVLASQSI QNTVYNDGQS SAIPVASVEF AAICLRNALL LLPEEQQDPK
     QENGSKSSSQ LGGNAESSES SETCSSKSHD GDKLIPAPPS SPLRKQELEN LKCSILACSA
     YVALALGDNL MALNHADQLL QQPKLSGSLK FLGHLYAAEA LISLDRISDA ITHLNPENVT
     DVSLGISSNE QDQGSDKGEN EAMESSGKRA PQCYPSSVNS ARTVMLFNLG SAYCLRSEYD
     KARKCLHQAA SMIHPKEVPP EAILLAVYLE LQNGNTQLAL QMIKRNQLLP AVKAHSDVRK
     KTVFQPVHPI QPIQMPAFTT VQRK