ID   CNO11_DANRE             Reviewed;         445 AA.
AC   A4QP78;
DT   19-JAN-2010, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=CCR4-NOT transcription complex subunit 11;
GN   Name=cnot11; ORFNames=zgc:163002;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the CCR4-NOT complex which is one of the major
CC       cellular mRNA deadenylases and is linked to various cellular processes
CC       including bulk mRNA degradation, miRNA-mediated repression,
CC       translational repression during translational initiation and general
CC       transcription regulation. Additional complex functions may be a
CC       consequence of its influence on mRNA expression. Is required for the
CC       association of cnot10 with the CCR4-NOT complex. Seems not to be
CC       required for complex deadenylase function (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the CCR4-NOT complex. cnot10 and cnot11 form a
CC       subcomplex docked to the cnot1 scaffold (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CNOT11 family. {ECO:0000305}.
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DR   EMBL; BC139685; AAI39686.1; -; mRNA.
DR   RefSeq; NP_001082810.1; NM_001089341.1.
DR   AlphaFoldDB; A4QP78; -.
DR   STRING; 7955.ENSDARP00000090050; -.
DR   PaxDb; A4QP78; -.
DR   PeptideAtlas; A4QP78; -.
DR   Ensembl; ENSDART00000099276; ENSDARP00000090050; ENSDARG00000068596.
DR   GeneID; 336124; -.
DR   KEGG; dre:336124; -.
DR   CTD; 55571; -.
DR   ZFIN; ZDB-GENE-030131-8068; cnot11.
DR   eggNOG; KOG4508; Eukaryota.
DR   GeneTree; ENSGT00390000006356; -.
DR   HOGENOM; CLU_028648_0_1_1; -.
DR   InParanoid; A4QP78; -.
DR   OMA; PDHSVQW; -.
DR   OrthoDB; 996942at2759; -.
DR   PhylomeDB; A4QP78; -.
DR   TreeFam; TF323711; -.
DR   Reactome; R-DRE-429947; Deadenylation of mRNA.
DR   Reactome; R-DRE-6804115; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.
DR   PRO; PR:A4QP78; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 9.
DR   Bgee; ENSDARG00000068596; Expressed in testis and 26 other tissues.
DR   GO; GO:0030014; C:CCR4-NOT complex; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
DR   GO; GO:0006402; P:mRNA catabolic process; IBA:GO_Central.
DR   GO; GO:0017148; P:negative regulation of translation; IBA:GO_Central.
DR   InterPro; IPR019312; CNOT11.
DR   PANTHER; PTHR15975; PTHR15975; 1.
DR   Pfam; PF10155; CNOT11; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; RNA-mediated gene silencing;
KW   Transcription; Transcription regulation; Translation regulation.
FT   CHAIN           1..445
FT                   /note="CCR4-NOT transcription complex subunit 11"
FT                   /id="PRO_0000390654"
FT   REGION          169..193
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   445 AA;  49707 MW;  5DAE0602A476E6F7 CRC64;
     MTLAPKDLSN LLGIMSEDAC SSSFEQLSSA FHHCFGKAEH FGVGSVLVML LQQPDLLPSA
     PQRLTALYLL WEMYRTEPLA ANPFAAVFAH LLNPSSAAEE QEKTLSGFLP PITLPEKFFL
     SQLMLAPPRE LFKKTPRQVS CMDITSTPQT IDISGLQLAL AERQSELPTQ SKASFPSLLS
     DPDPDSSNSG FDSSVANQIT ESLVTGPRPP LESHFRPEFI RPTPPLLVCE DELCWLNPCE
     PEHRVQWDRS MCVRNGTGVE IKRIMAKAFK SPLSAAQQTQ LLGELEKDLK LVYHIGLTPA
     KLPDLVENNP LVAIEMLLKL MSSSQITEYF SVLVNMDMSL HSMEVVNRLT TAVDLPPEFI
     HLYISNCIST CEQIKDKYMQ NRLVRLVCVF LQSLIRNKII NVQDLFIEVQ AFCIEFSRIR
     EAAGLFRLLK TLDNGETPAE GKTSK