ID   CNO11_DICDI             Reviewed;         642 AA.
AC   Q1ZXI2;
DT   19-JAN-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=CCR4-NOT transcription complex subunit 11;
GN   Name=cnot11; ORFNames=DDB_G0279005;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=16507593; DOI=10.1242/jcs.02819;
RA   Torija P., Vicente J.J., Rodrigues T.B., Robles A., Cerdan S., Sastre L.,
RA   Calvo R.M., Escalante R.;
RT   "Functional genomics in Dictyostelium: midA, a new conserved protein, is
RT   required for mitochondrial function and development.";
RL   J. Cell Sci. 119:1154-1164(2006).
CC   -!- FUNCTION: Component of the CCR4-NOT complex which is one of the major
CC       cellular mRNA deadenylases and is linked to various cellular processes
CC       including bulk mRNA degradation, miRNA-mediated repression,
CC       translational repression during translational initiation and general
CC       transcription regulation. Additional complex functions may be a
CC       consequence of its influence on mRNA expression (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the CCR4-NOT complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- DISRUPTION PHENOTYPE: No obvious phenotypic change is observed.
CC       {ECO:0000269|PubMed:16507593}.
CC   -!- SIMILARITY: Belongs to the CNOT11 family. {ECO:0000305}.
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DR   EMBL; AAFI02000026; EAS66887.1; -; Genomic_DNA.
DR   RefSeq; XP_001134571.1; XM_001134571.1.
DR   AlphaFoldDB; Q1ZXI2; -.
DR   STRING; 44689.DDB0232148; -.
DR   PaxDb; Q1ZXI2; -.
DR   EnsemblProtists; EAS66887; EAS66887; DDB_G0279005.
DR   GeneID; 8621826; -.
DR   KEGG; ddi:DDB_G0279005; -.
DR   dictyBase; DDB_G0279005; -.
DR   eggNOG; KOG4508; Eukaryota.
DR   HOGENOM; CLU_028648_0_0_1; -.
DR   InParanoid; Q1ZXI2; -.
DR   OMA; HFIPMYI; -.
DR   PhylomeDB; Q1ZXI2; -.
DR   Reactome; R-DDI-6804115; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.
DR   PRO; PR:Q1ZXI2; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0030014; C:CCR4-NOT complex; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
DR   GO; GO:0006402; P:mRNA catabolic process; IBA:GO_Central.
DR   GO; GO:0017148; P:negative regulation of translation; IBA:GO_Central.
DR   InterPro; IPR019312; CNOT11.
DR   PANTHER; PTHR15975; PTHR15975; 1.
DR   Pfam; PF10155; CNOT11; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; RNA-mediated gene silencing;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..642
FT                   /note="CCR4-NOT transcription complex subunit 11"
FT                   /id="PRO_0000390653"
FT   REGION          78..167
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          589..627
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   642 AA;  71069 MW;  AD864D17DF185180 CRC64;
     MIDSKDLATL LSLLDESDKP FETIATTFYR TFSKNDHFKV GCAIYTIIKD GFIRIPSQRL
     IGFYILFSLY KPDSSILSSN SLSSSSILTP SSTTTTTTTE HNNSNNNTSS PSFSSSTVPT
     NTTLQQNTPS STSQAISPSS STSSTSTSSY TNTTTNTTIP SSSPTSTTNT IIENVNDYPI
     AFNPFLPIFI DELEKQIDSS ISSPLFNPIE KQILPLFLTN LPKDFSKKTP KEIINIGMNN
     TANTTTTTTT TTTTATTNIT LPNISISKSS LKEYKNFYLE RLPNHCFPSF RSIGISQNIL
     FQLPSTTTTT TNTPTATTTT NTTINTQQSN PSLNTIKNHD INSEELSFFS FEPRFKRAEP
     PSFNPTTWIN PSINHGLLLS NPMSSTVAAT IAATATSAPT TILIPSPTTT TSYNSKKIVR
     DLMTKAIKGR LKKSQILQIK NEMDIDPKLA YYSGLTPKNL PFLVENNTQV AIDTLLKLIN
     SPDFKDHFQT LISMEMNFRS MEVVNALATV DLPPHFIPMY ITNCIDSCNN IKDKAMQQRS
     VRLVCVFIQS LIRNNIINIK NLFCEVQTFC LEFSKIREAI SLFKAINDNN NTNNTNTNTN
     TNNSNTTNTN NNNNNNNNNN NNNNNLINIG EENPNLIIMA TK