CNO11_HUMAN
ID CNO11_HUMAN Reviewed; 510 AA.
AC Q9UKZ1; Q6P2M9; Q8N681;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=CCR4-NOT transcription complex subunit 11;
GN Name=CNOT11; Synonyms=C2orf29; ORFNames=C40;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Mammary gland;
RX PubMed=10497265; DOI=10.1093/nar/27.20.4008;
RA Oh J.J., Grosshans D.R., Wong S.G., Slamon D.J.;
RT "Identification of differentially expressed genes associated with HER-2/neu
RT overexpression in human breast cancer cells.";
RL Nucleic Acids Res. 27:4008-4017(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION IN THE CCR4-NOT COMPLEX, AND COMPOSITION OF THE CCR4-NOT
RP COMPLEX.
RX PubMed=19558367; DOI=10.1042/bj20090500;
RA Lau N.C., Kolkman A., van Schaik F.M., Mulder K.W., Pijnappel W.W.,
RA Heck A.J., Timmers H.T.;
RT "Human Ccr4-Not complexes contain variable deadenylase subunits.";
RL Biochem. J. 422:443-453(2009).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [6]
RP IDENTIFICATION IN THE CCR4-NOT COMPLEX.
RX PubMed=23232451; DOI=10.4161/rna.23065;
RA Mauxion F., Preve B., Seraphin B.;
RT "C2ORF29/CNOT11 and CNOT10 form a new module of the CCR4-NOT complex.";
RL RNA Biol. 10:267-276(2013).
RN [7]
RP INTERACTION WITH CNOT1 AND CNOT10.
RX PubMed=23303381; DOI=10.4161/rna.23018;
RA Bawankar P., Loh B., Wohlbold L., Schmidt S., Izaurralde E.;
RT "NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex
RT that docks onto the NOT1 N-terminal domain.";
RL RNA Biol. 10:228-244(2013).
RN [8]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-41, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Colon carcinoma;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- FUNCTION: Component of the CCR4-NOT complex which is one of the major
CC cellular mRNA deadenylases and is linked to various cellular processes
CC including bulk mRNA degradation, miRNA-mediated repression,
CC translational repression during translational initiation and general
CC transcription regulation. Additional complex functions may be a
CC consequence of its influence on mRNA expression. Is required for the
CC association of CNOT10 with the CCR4-NOT complex. Seems not to be
CC required for complex deadenylase function.
CC -!- SUBUNIT: Component of the CCR4-NOT complex; distinct complexes seem to
CC exist that differ in the participation of probably mutually exclusive
CC catalytic subunits. CNOT10 and CNOT11 form a subcomplex docked to the
CC CNOT1 scaffold. {ECO:0000269|PubMed:19558367,
CC ECO:0000269|PubMed:23232451}.
CC -!- INTERACTION:
CC Q9UKZ1; Q53TS8: C2CD6; NbExp=3; IntAct=EBI-2562014, EBI-739879;
CC Q9UKZ1; A5YKK6: CNOT1; NbExp=4; IntAct=EBI-2562014, EBI-1222758;
CC Q9UKZ1; Q9H9A5: CNOT10; NbExp=4; IntAct=EBI-2562014, EBI-1054261;
CC Q9UKZ1; Q96PV7: FAM193B; NbExp=3; IntAct=EBI-2562014, EBI-741770;
CC Q9UKZ1; Q9HC44: GPBP1L1; NbExp=4; IntAct=EBI-2562014, EBI-746674;
CC Q9UKZ1; P50221: MEOX1; NbExp=3; IntAct=EBI-2562014, EBI-2864512;
CC Q9UKZ1; Q60809: Cnot7; Xeno; NbExp=3; IntAct=EBI-2562014, EBI-2104739;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CNOT11 family. {ECO:0000305}.
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DR EMBL; AF103798; AAF02418.1; -; mRNA.
DR EMBL; AC013722; AAY15088.1; -; Genomic_DNA.
DR EMBL; BC018664; AAH18664.2; -; mRNA.
DR EMBL; BC064421; AAH64421.1; -; mRNA.
DR CCDS; CCDS2050.1; -.
DR RefSeq; NP_060016.3; NM_017546.4.
DR AlphaFoldDB; Q9UKZ1; -.
DR BioGRID; 120724; 107.
DR ComplexPortal; CPX-2522; CCR4-NOT mRNA deadenylase complex, CNOT6L-CNOT7 variant.
DR ComplexPortal; CPX-2535; CCR4-NOT mRNA deadenylase complex, CNOT6L-CNOT8 variant.
DR ComplexPortal; CPX-2849; CCR4-NOT mRNA deadenylase complex, CNOT6-CNOT8 variant.
DR ComplexPortal; CPX-707; CCR4-NOT mRNA deadenylase complex, CNOT6-CNOT7 variant.
DR CORUM; Q9UKZ1; -.
DR IntAct; Q9UKZ1; 51.
DR MINT; Q9UKZ1; -.
DR STRING; 9606.ENSP00000289382; -.
DR ChEMBL; CHEMBL4105958; -.
DR GlyGen; Q9UKZ1; 2 sites, 1 O-linked glycan (2 sites).
DR iPTMnet; Q9UKZ1; -.
DR PhosphoSitePlus; Q9UKZ1; -.
DR BioMuta; CNOT11; -.
DR DMDM; 71152358; -.
DR EPD; Q9UKZ1; -.
DR jPOST; Q9UKZ1; -.
DR MassIVE; Q9UKZ1; -.
DR MaxQB; Q9UKZ1; -.
DR PaxDb; Q9UKZ1; -.
DR PeptideAtlas; Q9UKZ1; -.
DR PRIDE; Q9UKZ1; -.
DR ProteomicsDB; 84917; -.
DR Antibodypedia; 47523; 72 antibodies from 12 providers.
DR DNASU; 55571; -.
DR Ensembl; ENST00000289382.8; ENSP00000289382.3; ENSG00000158435.8.
DR GeneID; 55571; -.
DR KEGG; hsa:55571; -.
DR MANE-Select; ENST00000289382.8; ENSP00000289382.3; NM_017546.5; NP_060016.3.
DR UCSC; uc002taw.5; human.
DR CTD; 55571; -.
DR GeneCards; CNOT11; -.
DR HGNC; HGNC:25217; CNOT11.
DR HPA; ENSG00000158435; Low tissue specificity.
DR neXtProt; NX_Q9UKZ1; -.
DR OpenTargets; ENSG00000158435; -.
DR PharmGKB; PA134899354; -.
DR VEuPathDB; HostDB:ENSG00000158435; -.
DR eggNOG; KOG4508; Eukaryota.
DR GeneTree; ENSGT00390000006356; -.
DR HOGENOM; CLU_028648_0_1_1; -.
DR InParanoid; Q9UKZ1; -.
DR OMA; PDHSVQW; -.
DR OrthoDB; 996942at2759; -.
DR PhylomeDB; Q9UKZ1; -.
DR TreeFam; TF323711; -.
DR PathwayCommons; Q9UKZ1; -.
DR Reactome; R-HSA-429947; Deadenylation of mRNA.
DR Reactome; R-HSA-6804115; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.
DR SignaLink; Q9UKZ1; -.
DR SIGNOR; Q9UKZ1; -.
DR BioGRID-ORCS; 55571; 61 hits in 1077 CRISPR screens.
DR ChiTaRS; CNOT11; human.
DR GenomeRNAi; 55571; -.
DR Pharos; Q9UKZ1; Tbio.
DR PRO; PR:Q9UKZ1; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q9UKZ1; protein.
DR Bgee; ENSG00000158435; Expressed in oocyte and 178 other tissues.
DR ExpressionAtlas; Q9UKZ1; baseline and differential.
DR Genevisible; Q9UKZ1; HS.
DR GO; GO:0030014; C:CCR4-NOT complex; IDA:UniProtKB.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
DR GO; GO:0006402; P:mRNA catabolic process; IBA:GO_Central.
DR GO; GO:0017148; P:negative regulation of translation; IBA:GO_Central.
DR GO; GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; IC:ComplexPortal.
DR InterPro; IPR019312; CNOT11.
DR PANTHER; PTHR15975; PTHR15975; 1.
DR Pfam; PF10155; CNOT11; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Methylation; Nucleus; Reference proteome;
KW RNA-mediated gene silencing; Transcription; Transcription regulation;
KW Translation regulation.
FT CHAIN 1..510
FT /note="CCR4-NOT transcription complex subunit 11"
FT /id="PRO_0000089357"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 232..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 41
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT CONFLICT 507
FT /note="K -> E (in Ref. 3; AAH64421)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 510 AA; 55215 MW; E733DA59F1D0F280 CRC64;
MPGGGASAAS GRLLTAAEQR GSREAAGSAS RSGFGGSGGG RGGASGPGSG SGGPGGPAGR
MSLTPKELSS LLSIISEEAG GGSTFEGLST AFHHYFSKAD HFRLGSVLVM LLQQPDLLPS
AAQRLTALYL LWEMYRTEPL AANPFAASFA HLLNPAPPAR GGQEPDRPPL SGFLPPITPP
EKFFLSQLML APPRELFKKT PRQIALMDVG NMGQSVDISG LQLALAERQS ELPTQSKASF
PSILSDPDPD SSNSGFDSSV ASQITEALVS GPKPPIESHF RPEFIRPPPP LHICEDELAW
LNPTEPDHAI QWDKSMCVKN STGVEIKRIM AKAFKSPLSS PQQTQLLGEL EKDPKLVYHI
GLTPAKLPDL VENNPLVAIE MLLKLMQSSQ ITEYFSVLVN MDMSLHSMEV VNRLTTAVDL
PPEFIHLYIS NCISTCEQIK DKYMQNRLVR LVCVFLQSLI RNKIINVQDL FIEVQAFCIE
FSRIREAAGL FRLLKTLDTG ETPSETKMSK
