CNO11_MOUSE
ID CNO11_MOUSE Reviewed; 505 AA.
AC Q9CWN7; Q3TJG9;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=CCR4-NOT transcription complex subunit 11;
GN Name=Cnot11; Synonyms=D1Bwg0212e;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryonic stem cell, Lung, Placenta, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryonic testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Lung, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-39, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, and Embryo;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- FUNCTION: Component of the CCR4-NOT complex which is one of the major
CC cellular mRNA deadenylases and is linked to various cellular processes
CC including bulk mRNA degradation, miRNA-mediated repression,
CC translational repression during translational initiation and general
CC transcription regulation. Additional complex functions may be a
CC consequence of its influence on mRNA expression. Is required for the
CC association of CNOT10 with the CCR4-NOT complex. Seems not to be
CC required for complex deadenylase function (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of the CCR4-NOT complex; distinct complexes seem to
CC exist that differ in the participation of probably mutually exclusive
CC catalytic subunits. CNOT10 and CNOT11 form a subcomplex docke to the
CC CNOT1 scaffold (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CNOT11 family. {ECO:0000305}.
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DR EMBL; AK010503; BAB26988.1; -; mRNA.
DR EMBL; AK144692; BAE26018.1; -; mRNA.
DR EMBL; AK167440; BAE39526.1; -; mRNA.
DR EMBL; BC049091; AAH49091.1; -; mRNA.
DR EMBL; BC050812; AAH50812.1; -; mRNA.
DR CCDS; CCDS14906.1; -.
DR RefSeq; NP_082319.1; NM_028043.2.
DR AlphaFoldDB; Q9CWN7; -.
DR BioGRID; 206852; 2.
DR IntAct; Q9CWN7; 2.
DR MINT; Q9CWN7; -.
DR STRING; 10090.ENSMUSP00000125638; -.
DR iPTMnet; Q9CWN7; -.
DR PhosphoSitePlus; Q9CWN7; -.
DR EPD; Q9CWN7; -.
DR MaxQB; Q9CWN7; -.
DR PaxDb; Q9CWN7; -.
DR PeptideAtlas; Q9CWN7; -.
DR PRIDE; Q9CWN7; -.
DR ProteomicsDB; 283650; -.
DR Antibodypedia; 47523; 72 antibodies from 12 providers.
DR Ensembl; ENSMUST00000003219; ENSMUSP00000003219; ENSMUSG00000003135.
DR Ensembl; ENSMUST00000161515; ENSMUSP00000125638; ENSMUSG00000003135.
DR GeneID; 52846; -.
DR KEGG; mmu:52846; -.
DR UCSC; uc007ati.1; mouse.
DR CTD; 55571; -.
DR MGI; MGI:106580; Cnot11.
DR VEuPathDB; HostDB:ENSMUSG00000003135; -.
DR eggNOG; KOG4508; Eukaryota.
DR GeneTree; ENSGT00390000006356; -.
DR HOGENOM; CLU_028648_0_1_1; -.
DR InParanoid; Q9CWN7; -.
DR OMA; PDHSVQW; -.
DR OrthoDB; 996942at2759; -.
DR PhylomeDB; Q9CWN7; -.
DR TreeFam; TF323711; -.
DR Reactome; R-MMU-429947; Deadenylation of mRNA.
DR Reactome; R-MMU-6804115; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.
DR BioGRID-ORCS; 52846; 22 hits in 77 CRISPR screens.
DR PRO; PR:Q9CWN7; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q9CWN7; protein.
DR Bgee; ENSMUSG00000003135; Expressed in primary oocyte and 230 other tissues.
DR ExpressionAtlas; Q9CWN7; baseline and differential.
DR Genevisible; Q9CWN7; MM.
DR GO; GO:0030014; C:CCR4-NOT complex; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
DR GO; GO:0006402; P:mRNA catabolic process; IBA:GO_Central.
DR GO; GO:0017148; P:negative regulation of translation; IBA:GO_Central.
DR InterPro; IPR019312; CNOT11.
DR PANTHER; PTHR15975; PTHR15975; 1.
DR Pfam; PF10155; CNOT11; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Methylation; Nucleus; Reference proteome;
KW RNA-mediated gene silencing; Transcription; Transcription regulation;
KW Translation regulation.
FT CHAIN 1..505
FT /note="CCR4-NOT transcription complex subunit 11"
FT /id="PRO_0000089358"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 227..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 39
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
SQ SEQUENCE 505 AA; 54959 MW; CC2081AF5CE48B12 CRC64;
MPGGGASTAS GRLLSSADPR GAREAAAFRS GPAGSSGGRG GAGGPGPGIG GPAGRMSLTP
KELSSLLSII SEEAGGGSTF EGLSTAFHHY FSKADHFRLG SVLVMLLQQP DLLPSAAQRL
TALYLLWEMY RTEPLAANPF AASFAHLLNP APPARGGQEP DRPPLSGFLP PITPPEKFFL
SQLMLAPPRE LFKKTPRQIA LMDVGNMGQS VDISGLQLAL AERQSELPTQ SKASFPSILS
DPDPDSSNSG FDSSVASRIT ESLVSGPKPP IESHFRPEFI RPPPPLHICE DELAWLNPTE
PEHAIQWDRS MCVKNSTGVE IKRIMAKAFK SPLSSPQQTQ LLGELEKDPK LVYHIGLTPA
KLPDLVENNP LVAIEMLLKL MQSSQITEYF SVLVNMDMSL HSMEVVNRLT TAVDLPPEFI
HLYISNCIST CEQIKDKYMQ NRLVRLVCVF LQSLIRNKII NVQDLFIEVQ AFCIEFSRIR
EAAGLFRLLK TLDTGETPSE TKISK
