ID   CNO11_RAT               Reviewed;         504 AA.
AC   B0BNA9;
DT   19-JAN-2010, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=CCR4-NOT transcription complex subunit 11;
GN   Name=Cnot11;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Component of the CCR4-NOT complex which is one of the major
CC       cellular mRNA deadenylases and is linked to various cellular processes
CC       including bulk mRNA degradation, miRNA-mediated repression,
CC       translational repression during translational initiation and general
CC       transcription regulation. Additional complex functions may be a
CC       consequence of its influence on mRNA expression. Is required for the
CC       association of CNOT10 with the CCR4-NOT complex. Seems not to be
CC       required for complex deadenylase function (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the CCR4-NOT complex; distinct complexes seem to
CC       exist that differ in the participation of probably mutually exclusive
CC       catalytic subunits. CNOT10 and CNOT11 form a subcomplex docked to the
CC       CNOT1 scaffold (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CNOT11 family. {ECO:0000305}.
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DR   EMBL; CH473965; EDL99194.1; -; Genomic_DNA.
DR   EMBL; BC158750; AAI58751.1; -; mRNA.
DR   RefSeq; NP_001102264.1; NM_001108794.2.
DR   AlphaFoldDB; B0BNA9; -.
DR   STRING; 10116.ENSRNOP00000035943; -.
DR   iPTMnet; B0BNA9; -.
DR   PhosphoSitePlus; B0BNA9; -.
DR   jPOST; B0BNA9; -.
DR   PaxDb; B0BNA9; -.
DR   PeptideAtlas; B0BNA9; -.
DR   PRIDE; B0BNA9; -.
DR   Ensembl; ENSRNOT00000031352; ENSRNOP00000035943; ENSRNOG00000023220.
DR   GeneID; 363221; -.
DR   KEGG; rno:363221; -.
DR   UCSC; RGD:1560909; rat.
DR   CTD; 55571; -.
DR   RGD; 1560909; Cnot11.
DR   eggNOG; KOG4508; Eukaryota.
DR   GeneTree; ENSGT00390000006356; -.
DR   HOGENOM; CLU_028648_0_1_1; -.
DR   InParanoid; B0BNA9; -.
DR   OMA; PDHSVQW; -.
DR   OrthoDB; 996942at2759; -.
DR   PhylomeDB; B0BNA9; -.
DR   TreeFam; TF323711; -.
DR   Reactome; R-RNO-429947; Deadenylation of mRNA.
DR   Reactome; R-RNO-6804115; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.
DR   PRO; PR:B0BNA9; -.
DR   Proteomes; UP000002494; Chromosome 9.
DR   Proteomes; UP000234681; Chromosome 9.
DR   Bgee; ENSRNOG00000023220; Expressed in thymus and 19 other tissues.
DR   Genevisible; B0BNA9; RN.
DR   GO; GO:0030014; C:CCR4-NOT complex; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
DR   GO; GO:0006402; P:mRNA catabolic process; IBA:GO_Central.
DR   GO; GO:0017148; P:negative regulation of translation; IBA:GO_Central.
DR   InterPro; IPR019312; CNOT11.
DR   PANTHER; PTHR15975; PTHR15975; 1.
DR   Pfam; PF10155; CNOT11; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Methylation; Nucleus; Reference proteome;
KW   RNA-mediated gene silencing; Transcription; Transcription regulation;
KW   Translation regulation.
FT   CHAIN           1..504
FT                   /note="CCR4-NOT transcription complex subunit 11"
FT                   /id="PRO_0000390655"
FT   REGION          1..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          226..253
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         38
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UKZ1"
SQ   SEQUENCE   504 AA;  54836 MW;  3E0BF7825656A901 CRC64;
     MPGGGASTAS GRLLSADPRG AREAAAFRSG PAGSSGGRGG AGGPGSGSGG PAGRMSLTPK
     ELSSLLSIIS EEAGGGSTFE GLSTAFHHYF SKADHFRLGS VLVMLLQQPD LLPSAAQRLT
     ALYLLWEMYR TEPLAANPFA ASFAHLLNPA PPARGGQEPD RPPLSGFLPP ITPPEKFFLS
     QLMLAPPREL FKKTPRQIAL MDVGNMGQSV DISGLQLALA ERQSELPTQS KASFPSILSD
     PDPDSSNSAF DSSVASRITE SLVSGPKPPI ESHFRPEFIR PPPPLHICED ELAWLNPTEP
     EHAIQWDRSM CVKNSTGVEI KRIMAKAFKS PLSSPQQTQL LGELEKDPKL VYHIGLTPAK
     LPDLVENNPL VAIEMLLKLM QSSQITEYFS VLVNMDMSLH SMEVVNRLTT AVDLPPEFIH
     LYISNCISTC EQIKDKYMQN RLVRLVCVFL QSLIRNKIIN VQDLFIEVQA FCIEFSRIRE
     AAGLFRLLKT LDTGETPSET KVSK