CNOT1_XENTR
ID CNOT1_XENTR Reviewed; 2388 AA.
AC A0JP85;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 12-DEC-2006, sequence version 1.
DT 03-AUG-2022, entry version 68.
DE RecName: Full=CCR4-NOT transcription complex subunit 1;
DE AltName: Full=CCR4-associated factor 1;
GN Name=cnot1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Scaffolding component of the CCR4-NOT complex which is one of
CC the major cellular mRNA deadenylases and is linked to various cellular
CC processes including bulk mRNA degradation, miRNA-mediated repression,
CC translational repression during translational initiation and general
CC transcription regulation. Additional complex functions may be a
CC consequence of its influence on mRNA expression. Its scaffolding
CC function implies its interaction with the catalytic complex module and
CC diverse RNA-binding proteins mediating the complex recruitment to
CC selected mRNA 3'UTRs. Acts as a transcriptional repressor. Represses
CC the ligand-dependent transcriptional activation by nuclear receptors
CC (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the CCR4-NOT complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- DOMAIN: Contains Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, a motif known to
CC be important for the association with nuclear receptors. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CNOT1 family. {ECO:0000305}.
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DR EMBL; BC127296; AAI27297.1; -; mRNA.
DR RefSeq; NP_001090658.1; NM_001097189.1.
DR AlphaFoldDB; A0JP85; -.
DR SMR; A0JP85; -.
DR PaxDb; A0JP85; -.
DR PRIDE; A0JP85; -.
DR DNASU; 100036630; -.
DR GeneID; 100036630; -.
DR KEGG; xtr:100036630; -.
DR CTD; 23019; -.
DR Xenbase; XB-GENE-1032888; cnot1.
DR eggNOG; KOG1831; Eukaryota.
DR InParanoid; A0JP85; -.
DR OrthoDB; 42530at2759; -.
DR Reactome; R-XTR-429947; Deadenylation of mRNA.
DR Reactome; R-XTR-6804115; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.
DR Proteomes; UP000008143; Chromosome 4.
DR Proteomes; UP000790000; Unplaced.
DR GO; GO:0030014; C:CCR4-NOT complex; ISS:UniProtKB.
DR GO; GO:0030015; C:CCR4-NOT core complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000932; C:P-body; ISS:UniProtKB.
DR GO; GO:0060090; F:molecular adaptor activity; IBA:GO_Central.
DR GO; GO:0030331; F:nuclear estrogen receptor binding; ISS:UniProtKB.
DR GO; GO:0042974; F:nuclear retinoic acid receptor binding; ISS:UniProtKB.
DR GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
DR GO; GO:0033147; P:negative regulation of intracellular estrogen receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0048387; P:negative regulation of retinoic acid receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0000288; P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; IBA:GO_Central.
DR GO; GO:0010606; P:positive regulation of cytoplasmic mRNA processing body assembly; ISS:UniProtKB.
DR GO; GO:1900153; P:positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; ISS:UniProtKB.
DR GO; GO:0060213; P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; ISS:UniProtKB.
DR Gene3D; 1.25.40.840; -; 1.
DR InterPro; IPR007196; CCR4-Not_Not1_C.
DR InterPro; IPR032191; CNOT1_CAF1_bind.
DR InterPro; IPR024557; CNOT1_dom_4.
DR InterPro; IPR032194; CNOT1_HEAT.
DR InterPro; IPR032193; CNOT1_TTP_bind.
DR InterPro; IPR038535; CNOT1_TTP_bind_sf.
DR InterPro; IPR040398; Not1.
DR PANTHER; PTHR13162; PTHR13162; 1.
DR Pfam; PF16415; CNOT1_CAF1_bind; 1.
DR Pfam; PF16418; CNOT1_HEAT; 1.
DR Pfam; PF16417; CNOT1_TTP_bind; 1.
DR Pfam; PF12842; DUF3819; 1.
DR Pfam; PF04054; Not1; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Nucleus; Reference proteome; Repressor;
KW RNA-mediated gene silencing; Transcription; Transcription regulation;
KW Translation regulation.
FT CHAIN 1..2388
FT /note="CCR4-NOT transcription complex subunit 1"
FT /id="PRO_0000315544"
FT REGION 1012..1035
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1076..1617
FT /note="Interaction with CCR4-NOT complex catalytic
FT subunits"
FT /evidence="ECO:0000250"
FT REGION 1300..1320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 153..157
FT /note="LXXLL"
FT MOTIF 181..185
FT /note="LXXLL"
FT MOTIF 223..227
FT /note="LXXLL"
FT MOTIF 570..574
FT /note="LXXLL"
FT MOTIF 1651..1655
FT /note="LXXLL"
FT MOTIF 1954..1958
FT /note="LXXLL"
FT MOTIF 2108..2112
FT /note="LXXLL"
SQ SEQUENCE 2388 AA; 268153 MW; 80A2D43D6BED5FF9 CRC64;
MNLDSLSLAL SQISYLVDNL TKKNYRASQL EIQHIVNRHG PEADRHLLRC LFSHVDFSGD
GKSSGKDFHQ TQFLIQECAS LITKPNFIST LSYAIDNPLH YQKSLKPSPH LFAQLSKVLK
LSKVQEVIFG LALLNSSSCE LRGFAAQFVK QKLPDLLRSY VDVDVSGSQE GGFQDIAIEV
LHLLLSNLLF GQKGAFGVGQ EQIVAFLKTL RRDFPQERCP VVLAPLLYPE KRDILMDRIL
ADSGGITKTM MDSSLADFMQ EVGYSFCASV EECRNVIVQF GVREVTAVQV ARVLGMMART
HSGLTDGIPL QSITSPGSGI WSDGKDKNDA VQPHTWNVEV LIDVVKELNP TLNFKEVTYE
LDNPSFQIRD SKGLQTVVYG IQRGLGIEAF PVDLVYRPWK NAEGQLSFIQ HSLVNPDVFC
FADYACHAVA TDILKAPPED DNREIATWKS LDLIESLLRL AELGQYEQVK QLFAYPIKHC
PDMLVLALLQ INTTWHTLRH ELISTLMPIF LGNHPNSAII LHYAWHGQGQ SPSIRQLIMH
AMAEWYMRGE QYDQARLSRI LDVAQDLKAL SMLLNGTPFA FVIDLAALAS RREYLKLDKW
LTDKIREHGE PFIQACMTFL KRRCPSILGG LAPEKDQPKS AQLPPETLAT MLACLQACAG
SVSQELSETI LTMVANCSNV VNKARQPPPG VMPKGRPPST SSLDAISPVQ IDPIAAMASL
SIGGSAAPHT QSMPVFPPNL GSAFSTPQSP AKAFPPLTAP NQSTAFSGLG GLTSQLPGGL
GTGSLTGMGT GGLSLPTVNS DPFGQRKLST SGLNQPTFQQ TDLSQVWPEA NQHFSKEIDD
EANSYFQRIY NQPPHPTMSV DEVLEMLQRF KDSNIKRERE VFNCMLRNLF EEYRFFPQYP
DKELHITACL FGGIIEKGLV TYMALGLALR YVLEALRKPY QSKMYFFGIA ALDRFKNRLK
DYPQYCQHLA SISHFMQFPH HLQEYIEYGQ QSRDPPVKMQ GSITTPGSIA LSQAQTPAKP
ASSSAVTTPT TTTPAKTITI TRPTGVSFKK DVPPSINTTN IDTLLVATDL AGQIVEPPEN
VQEKIAFIFN NLSQSNMTQK VEELKETVKD DYMPWVSQYL VMKRVSIELN FHSLYSNFLD
ALKHLEFNKM VLAETYRNIK VLLTSDKAAA NFSDRSLLKN LGHWLGMITL AKNKPILHTD
LDLKSLLLEA YVKGQQELLY VVPFVAKVLE SSVRSVVFRP PNPWTMAIMN VLAELHQEHD
LKLNLKFEIE VLCKNLVLDI NDLKPGTLLK DKDRLKSLDE QLSAPKKDVK QPEELPPMTS
ASEYAIRTAG KLWASVEKQE SDAVFTATAT APPPSTTCTT TVPPQPQYSY HDIHVYSLAG
LAPHITLNPT IPLFQAHPQL KQCVRQAIER AVQELVHPVV DRSIKIAMTT CEQIVRKDFA
LDSEESRMRI AAHHMMRNLT AGMAMITCRE PLLMSIATNL KNSFATAMRA ASPQQREMME
QAAAQLAQDN CELACCFIQK TAVEKAGPEM DKRPATEFEL RKHARQEGRR YCDPVVLTYQ
AERMPEQIRL KVGGVDPKQL AVYEEFARNV PGFLPTNDLT QPTGFLAQPM KQQAWATDDV
AQIYDKCITE LEQHLHAIPP ALSMNPQSQA LRSLLEAVAV ARNSRDAIAA LGLLQKAVEG
LLDATSGADA DLLLRYRECH LLVLKALQDG RAYGSPWCNK QITRCLIECR DEYKYNVEAV
ELLIRNHLVN MQQYDLHLAQ SMENGLNYMA VAFAMQLVKI LLVDERSVSH VTEAEFFHTI
ETLMRINAHS RGNAPEGLPQ LMDVLRSNFD AMMERAHGGP NFMMHSGISQ ASEYDDPPGL
REKAEYLLRE WVNLYHSAAA GRDSTKAFSA FVGQMHQQGI LKTDDLITRF FRLCTEMCVE
ISYRAQAEQQ HNPAANPTMI RAKCYHNLDA FVRLIALLVK HSGEATNTVT KINLLNKVLG
IVVGVLLQDH EVRQSEFQQL PYHRIFIMLL LELNAPEHVL ETINFQTLTA FCNTFHILRP
TKAPGFVYAW LELISHRIFI ARMLAHTPQQ KGWPMYAQLL IDLFKYLAPF LRNVELTKPM
QILYKGTLRV LLVLLHDFPE FLCDYHYGFC DVIPPNCIQL RNLILSAFPR NMRLPDPFTP
NLKVDMLSEI NIAPRILTNF TGVMPPQFKK DLDSYLKTRS PVTFLSELRS NLQVSNEPGN
RYNIQLINAL VLYVGTQAIA HIHNKGSTPS MSTITHSAHM DIFQNLAVDL DTEGRYLFLN
AIANQLRYPN SHTHYFSCTM LYLFAEANTE AIQEQITRVL LERLIVNRPH PWGLLITFIE
LIKNPAFKFW NHEFVHCAPE IEKLFQSVAQ CCMGQKQAQQ VMEGTGAS
