ID   CNOT9_DANRE             Reviewed;         298 AA.
AC   Q6NWL4;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=CCR4-NOT transcription complex subunit 9 {ECO:0000250|UniProtKB:Q92600};
DE   AltName: Full=Cell differentiation protein RQCD1 homolog;
DE            Short=Rcd-1;
GN   Name=cnot9 {ECO:0000250|UniProtKB:Q92600}; Synonyms=rcd1, rqcd1;
GN   ORFNames=si:dkeyp-84a8.6, zgc:85618;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the CCR4-NOT complex which is one of the major
CC       cellular mRNA deadenylases and is linked to various cellular processes
CC       including bulk mRNA degradation, miRNA-mediated repression,
CC       translational repression during translational initiation and general
CC       transcription regulation. Additional complex functions may be a
CC       consequence of its influence on mRNA expression. Involved in down-
CC       regulation of MYB- and JUN-dependent transcription. Enhances ligand-
CC       dependent transcriptional activity of nuclear hormone receptors. May
CC       play a role in cell differentiation. {ECO:0000250|UniProtKB:Q9JKY0}.
CC   -!- SUBUNIT: Homodimer. Component of the CCR4-NOT complex (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9JKY0}.
CC       Cytoplasm, P-body {ECO:0000250|UniProtKB:Q9JKY0}.
CC   -!- SIMILARITY: Belongs to the CNOT9 family. {ECO:0000305}.
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DR   EMBL; BX548072; CAK11458.1; -; Genomic_DNA.
DR   EMBL; BC067547; AAH67547.1; -; mRNA.
DR   RefSeq; NP_999925.1; NM_214760.2.
DR   AlphaFoldDB; Q6NWL4; -.
DR   SMR; Q6NWL4; -.
DR   STRING; 7955.ENSDARP00000047463; -.
DR   PaxDb; Q6NWL4; -.
DR   DNASU; 406632; -.
DR   Ensembl; ENSDART00000143574; ENSDARP00000113790; ENSDARG00000033855.
DR   GeneID; 406632; -.
DR   KEGG; dre:406632; -.
DR   CTD; 9125; -.
DR   ZFIN; ZDB-GENE-030131-1558; cnot9.
DR   eggNOG; KOG3036; Eukaryota.
DR   GeneTree; ENSGT00390000001225; -.
DR   HOGENOM; CLU_039962_2_0_1; -.
DR   InParanoid; Q6NWL4; -.
DR   OMA; SAWMHQQ; -.
DR   OrthoDB; 1129961at2759; -.
DR   PhylomeDB; Q6NWL4; -.
DR   TreeFam; TF105734; -.
DR   Reactome; R-DRE-429947; Deadenylation of mRNA.
DR   Reactome; R-DRE-6804115; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.
DR   PRO; PR:Q6NWL4; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 22.
DR   Bgee; ENSDARG00000033855; Expressed in testis and 28 other tissues.
DR   GO; GO:0030014; C:CCR4-NOT complex; ISS:UniProtKB.
DR   GO; GO:0030015; C:CCR4-NOT core complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000932; C:P-body; IBA:GO_Central.
DR   GO; GO:0030374; F:nuclear receptor coactivator activity; ISS:UniProtKB.
DR   GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
DR   GO; GO:0006402; P:mRNA catabolic process; IEA:InterPro.
DR   GO; GO:0033147; P:negative regulation of intracellular estrogen receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0017148; P:negative regulation of translation; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR007216; CNOT9.
DR   PANTHER; PTHR12262:SF0; PTHR12262:SF0; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Activator; Cytoplasm; Nucleus; Reference proteome; Repressor;
KW   RNA-mediated gene silencing; Transcription; Transcription regulation;
KW   Translation regulation.
FT   CHAIN           1..298
FT                   /note="CCR4-NOT transcription complex subunit 9"
FT                   /id="PRO_0000327230"
SQ   SEQUENCE   298 AA;  33356 MW;  BC1465953BF09E45 CRC64;
     MLATGATVST AGLAQVDREK IYQWINELSS PETRENALLE LSKKRESVTD LAPMLWHSCG
     TIAALLQEIV NIYPSINPPT LTAHQSNRVC NALALLQCVA SHVETRSAFL AAHIPLFLYP
     FLHTVSKTRP FEYLRLTSLG VIGALVKTDE QEVINFLLTT EIIPLCLRIM ESGSELSKTV
     ATFILQKILL DDTGLAYICQ TYERFSHVAM ILGKMVLQLS KEPSARLLKH VVRCYLRLSD
     NSRAREALRQ CLPDQLKDTT FAQVLKDDST TKRWLAQLVK NLQEGQVTDP RGIPLPTQ