ID   CNOT9_MACFA             Reviewed;         299 AA.
AC   Q4R347;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=CCR4-NOT transcription complex subunit 9 {ECO:0000250|UniProtKB:Q92600};
DE   AltName: Full=Cell differentiation protein RQCD1 homolog;
DE            Short=Rcd-1;
GN   Name=CNOT9 {ECO:0000250|UniProtKB:Q92600}; Synonyms=RCD1, RQCD1;
GN   ORFNames=QtsA-19705;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the CCR4-NOT complex which is one of the major
CC       cellular mRNA deadenylases and is linked to various cellular processes
CC       including bulk mRNA degradation, miRNA-mediated repression,
CC       translational repression during translational initiation and general
CC       transcription regulation. Additional complex functions may be a
CC       consequence of its influence on mRNA expression. Involved in down-
CC       regulation of MYB- and JUN-dependent transcription. Enhances ligand-
CC       dependent transcriptional activity of nuclear hormone receptors. May
CC       play a role in cell differentiation. {ECO:0000250|UniProtKB:Q9JKY0}.
CC   -!- SUBUNIT: Homodimer. Component of the CCR4-NOT complex; distinct
CC       complexes seem to exist that differ in the participation of probably
CC       mutually exclusive catalytic subunits. Interacts with MYB, ATF2, RARA,
CC       RARB, RARG, RXRA, RXRB and RXRG. Identified in a complex with ATF2
CC       bound to target DNA. Interacts with NANOS2. Directly interacts with
CC       ZNF335 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9JKY0}.
CC       Cytoplasm, P-body {ECO:0000250|UniProtKB:Q9JKY0}. Note=NANOS2 promotes
CC       its localization to P-body. {ECO:0000250|UniProtKB:Q9JKY0}.
CC   -!- SIMILARITY: Belongs to the CNOT9 family. {ECO:0000305}.
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DR   EMBL; AB179421; BAE02472.1; -; mRNA.
DR   RefSeq; NP_001270704.1; NM_001283775.1.
DR   AlphaFoldDB; Q4R347; -.
DR   SMR; Q4R347; -.
DR   STRING; 9541.XP_005574342.1; -.
DR   GeneID; 101866077; -.
DR   CTD; 9125; -.
DR   eggNOG; KOG3036; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0030014; C:CCR4-NOT complex; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000932; C:P-body; ISS:UniProtKB.
DR   GO; GO:0030374; F:nuclear receptor coactivator activity; ISS:UniProtKB.
DR   GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
DR   GO; GO:0006402; P:mRNA catabolic process; IEA:InterPro.
DR   GO; GO:0033147; P:negative regulation of intracellular estrogen receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR007216; CNOT9.
DR   PANTHER; PTHR12262:SF0; PTHR12262:SF0; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Activator; Cytoplasm; Nucleus; Reference proteome; Repressor;
KW   RNA-mediated gene silencing; Transcription; Transcription regulation;
KW   Translation regulation.
FT   CHAIN           1..299
FT                   /note="CCR4-NOT transcription complex subunit 9"
FT                   /id="PRO_0000327226"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q92600"
SQ   SEQUENCE   299 AA;  33601 MW;  A4CA5DBE2E88DDA3 CRC64;
     MHSLATAAPV PTALAQVDRE KIYQWINELS SPETRENALL ELSKKRESVP DLAPMLWHSF
     GTIAALLQEI VNIYPSINPP TLTAHQSNRV CNALALLQCV ASHPETRSAF LAAHIPLFLY
     PFLHTVSKTR PFEYLRLTSL GVIGALVKTD EQEVINFLLT TEIIPLCLRI MESGSELSKT
     VATFILQKIL LDDTGLAYIC QTYERFSHVA MILGKMVLQL SKEPSARLLK HVVRCYLRLS
     DNPRAREALR QCLPDQLKDT TFAQVLKDDT TTKRWLAQLV KNLQEGQVTD PRGIPLPPQ