ID   CNOT9_PONAB             Reviewed;         299 AA.
AC   Q5R6Z6; Q5R8V4;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 2.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=CCR4-NOT transcription complex subunit 9 {ECO:0000250|UniProtKB:Q92600};
DE   AltName: Full=Cell differentiation protein RQCD1 homolog;
DE            Short=Rcd-1;
GN   Name=CNOT9 {ECO:0000250|UniProtKB:Q92600}; Synonyms=RCD1, RQCD1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the CCR4-NOT complex which is one of the major
CC       cellular mRNA deadenylases and is linked to various cellular processes
CC       including bulk mRNA degradation, miRNA-mediated repression,
CC       translational repression during translational initiation and general
CC       transcription regulation. Additional complex functions may be a
CC       consequence of its influence on mRNA expression. Involved in down-
CC       regulation of MYB- and JUN-dependent transcription. Enhances ligand-
CC       dependent transcriptional activity of nuclear hormone receptors. May
CC       play a role in cell differentiation. {ECO:0000250|UniProtKB:Q9JKY0}.
CC   -!- SUBUNIT: Homodimer. Component of the CCR4-NOT complex; distinct
CC       complexes seem to exist that differ in the participation of probably
CC       mutually exclusive catalytic subunits. Interacts with MYB, ATF2, RARA,
CC       RARB, RARG, RXRA, RXRB and RXRG. Identified in a complex with ATF2
CC       bound to target DNA. Interacts with NANOS2. Directly interacts with
CC       ZNF335 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9JKY0}.
CC       Cytoplasm, P-body {ECO:0000250|UniProtKB:Q9JKY0}. Note=NANOS2 promotes
CC       its localization to P-body. {ECO:0000250|UniProtKB:Q9JKY0}.
CC   -!- SIMILARITY: Belongs to the CNOT9 family. {ECO:0000305}.
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DR   EMBL; CR859645; CAH91806.1; -; mRNA.
DR   EMBL; CR860327; CAH92464.1; -; mRNA.
DR   RefSeq; NP_001126453.1; NM_001132981.1.
DR   AlphaFoldDB; Q5R6Z6; -.
DR   SMR; Q5R6Z6; -.
DR   STRING; 9601.ENSPPYP00000014723; -.
DR   Ensembl; ENSPPYT00000059560; ENSPPYP00000043942; ENSPPYG00000036751.
DR   GeneID; 100173439; -.
DR   KEGG; pon:100173439; -.
DR   CTD; 9125; -.
DR   eggNOG; KOG3036; Eukaryota.
DR   GeneTree; ENSGT00390000001225; -.
DR   HOGENOM; CLU_039962_2_0_1; -.
DR   InParanoid; Q5R6Z6; -.
DR   OMA; SAWMHQQ; -.
DR   OrthoDB; 1129961at2759; -.
DR   TreeFam; TF105734; -.
DR   Proteomes; UP000001595; Chromosome 2B.
DR   GO; GO:0030014; C:CCR4-NOT complex; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000932; C:P-body; ISS:UniProtKB.
DR   GO; GO:0030374; F:nuclear receptor coactivator activity; ISS:UniProtKB.
DR   GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
DR   GO; GO:0006402; P:mRNA catabolic process; IEA:InterPro.
DR   GO; GO:0033147; P:negative regulation of intracellular estrogen receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR007216; CNOT9.
DR   PANTHER; PTHR12262:SF0; PTHR12262:SF0; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Activator; Cytoplasm; Nucleus; Reference proteome; Repressor;
KW   RNA-mediated gene silencing; Transcription; Transcription regulation;
KW   Translation regulation.
FT   CHAIN           1..299
FT                   /note="CCR4-NOT transcription complex subunit 9"
FT                   /id="PRO_0000327228"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q92600"
FT   CONFLICT        23
FT                   /note="Y -> H (in Ref. 1; CAH92464)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        68
FT                   /note="Q -> L (in Ref. 1; CAH91806)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   299 AA;  33631 MW;  CFA0E108F5E9D8F2 CRC64;
     MHSLATAAPV PTTLAQVDRE KIYQWINELS SPETRENALL ELSKKRESVP DLAPMLWHSF
     GTIAALLQEI VNIYPSINPP TLTAHQSNRV CNALALLQCV ASHPETRSAF LAAHIPLFLY
     PFLHTVSKTR PFEYLRLTSL GVIGALVKTD EQEVINFLLT TEIIPLCLRI MESGSELSKT
     VATFILQKIL LDDTGLAYIC QTYERFSHVA MILGKMVLQL SKEPSARLLK HVVRCYLRLS
     DNPRAREALR QCLPDQLKDT TFAQVLKDDT TTKRWLAQLV KNLQEGQVTD PRGIPLPPQ