CNOT9_RAT
ID CNOT9_RAT Reviewed; 299 AA.
AC Q5PQL2;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=CCR4-NOT transcription complex subunit 9;
DE AltName: Full=Cell differentiation protein RQCD1 homolog;
DE Short=Rcd-1;
GN Name=Cnot9; Synonyms=Rcd1, Rqcd1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP TISSUE SPECIFICITY.
RX PubMed=12356739; DOI=10.1093/emboj/cdf521;
RA Hiroi N., Ito T., Yamamoto H., Ochiya T., Jinno S., Okayama H.;
RT "Mammalian Rcd1 is a novel transcriptional cofactor that mediates retinoic
RT acid-induced cell differentiation.";
RL EMBO J. 21:5235-5244(2002).
RN [3]
RP FUNCTION, AND INTERACTION WITH ZNF335.
RX PubMed=18180299; DOI=10.1074/jbc.m706986200;
RA Garapaty S., Mahajan M.A., Samuels H.H.;
RT "Components of the CCR4-NOT complex function as nuclear hormone receptor
RT coactivators via association with the NRC-interacting Factor NIF-1.";
RL J. Biol. Chem. 283:6806-6816(2008).
CC -!- FUNCTION: Component of the CCR4-NOT complex which is one of the major
CC cellular mRNA deadenylases and is linked to various cellular processes
CC including bulk mRNA degradation, miRNA-mediated repression,
CC translational repression during translational initiation and general
CC transcription regulation. Additional complex functions may be a
CC consequence of its influence on mRNA expression. Involved in down-
CC regulation of MYB- and JUN-dependent transcription. Enhances ligand-
CC dependent transcriptional activity of nuclear hormone receptors. May
CC play a role in cell differentiation (By similarity). {ECO:0000250,
CC ECO:0000269|PubMed:18180299}.
CC -!- SUBUNIT: Homodimer. Component of the CCR4-NOT complex; distinct
CC complexes seem to exist that differ in the participation of probably
CC mutually exclusive catalytic subunits. Interacts with MYB, ATF2, RARA,
CC RARB, RARG, RXRA, RXRB and RXRG. Identified in a complex with ATF2
CC bound to target DNA. Interacts with NANOS2. Directly interacts with
CC ZNF335. {ECO:0000269|PubMed:18180299}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9JKY0}.
CC Cytoplasm, P-body {ECO:0000250|UniProtKB:Q9JKY0}. Note=NANOS2 promotes
CC its localization to P-body. {ECO:0000250|UniProtKB:Q9JKY0}.
CC -!- TISSUE SPECIFICITY: Detected in adult spleen, thymus, testis, bone
CC marrow, lung and brain. Detected in embryonic brain, liver, lung,
CC intestine, heart, kidney, thymus and spleen (at protein level).
CC {ECO:0000269|PubMed:12356739}.
CC -!- SIMILARITY: Belongs to the CNOT9 family. {ECO:0000305}.
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DR EMBL; BC087134; AAH87134.1; -; mRNA.
DR RefSeq; NP_001009357.1; NM_001009357.1.
DR AlphaFoldDB; Q5PQL2; -.
DR SMR; Q5PQL2; -.
DR BioGRID; 256986; 1.
DR IntAct; Q5PQL2; 6.
DR STRING; 10116.ENSRNOP00000021548; -.
DR jPOST; Q5PQL2; -.
DR PaxDb; Q5PQL2; -.
DR PRIDE; Q5PQL2; -.
DR Ensembl; ENSRNOT00000100848; ENSRNOP00000097848; ENSRNOG00000016034.
DR GeneID; 301513; -.
DR KEGG; rno:301513; -.
DR UCSC; RGD:1311495; rat.
DR CTD; 9125; -.
DR RGD; 1311495; Cnot9.
DR eggNOG; KOG3036; Eukaryota.
DR GeneTree; ENSGT00390000001225; -.
DR HOGENOM; CLU_039962_2_0_1; -.
DR InParanoid; Q5PQL2; -.
DR OMA; SAWMHQQ; -.
DR OrthoDB; 1129961at2759; -.
DR PhylomeDB; Q5PQL2; -.
DR TreeFam; TF105734; -.
DR Reactome; R-RNO-429947; Deadenylation of mRNA.
DR Reactome; R-RNO-6804115; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.
DR PRO; PR:Q5PQL2; -.
DR Proteomes; UP000002494; Chromosome 9.
DR Bgee; ENSRNOG00000016034; Expressed in thymus and 20 other tissues.
DR Genevisible; Q5PQL2; RN.
DR GO; GO:0030014; C:CCR4-NOT complex; ISS:UniProtKB.
DR GO; GO:0030015; C:CCR4-NOT core complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000932; C:P-body; ISS:UniProtKB.
DR GO; GO:0032991; C:protein-containing complex; ISO:RGD.
DR GO; GO:0005154; F:epidermal growth factor receptor binding; ISO:RGD.
DR GO; GO:0019900; F:kinase binding; ISO:RGD.
DR GO; GO:0030374; F:nuclear receptor coactivator activity; ISS:UniProtKB.
DR GO; GO:0019904; F:protein domain specific binding; ISO:RGD.
DR GO; GO:0042803; F:protein homodimerization activity; ISO:RGD.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; ISO:RGD.
DR GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
DR GO; GO:0006402; P:mRNA catabolic process; IEA:InterPro.
DR GO; GO:0033147; P:negative regulation of intracellular estrogen receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0017148; P:negative regulation of translation; IBA:GO_Central.
DR GO; GO:0045742; P:positive regulation of epidermal growth factor receptor signaling pathway; ISO:RGD.
DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; ISO:RGD.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR007216; CNOT9.
DR PANTHER; PTHR12262:SF0; PTHR12262:SF0; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Acetylation; Activator; Cytoplasm; Nucleus; Reference proteome; Repressor;
KW RNA-mediated gene silencing; Transcription; Transcription regulation;
KW Translation regulation.
FT CHAIN 1..299
FT /note="CCR4-NOT transcription complex subunit 9"
FT /id="PRO_0000327229"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q92600"
SQ SEQUENCE 299 AA; 33601 MW; A4CA5DBE2E88DDA3 CRC64;
MHSLATAAPV PTALAQVDRE KIYQWINELS SPETRENALL ELSKKRESVP DLAPMLWHSF
GTIAALLQEI VNIYPSINPP TLTAHQSNRV CNALALLQCV ASHPETRSAF LAAHIPLFLY
PFLHTVSKTR PFEYLRLTSL GVIGALVKTD EQEVINFLLT TEIIPLCLRI MESGSELSKT
VATFILQKIL LDDTGLAYIC QTYERFSHVA MILGKMVLQL SKEPSARLLK HVVRCYLRLS
DNPRAREALR QCLPDQLKDT TFAQVLKDDT TTKRWLAQLV KNLQEGQVTD PRGIPLPPQ
