CNOT9_XENLA
ID CNOT9_XENLA Reviewed; 299 AA.
AC Q6IP65;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=CCR4-NOT transcription complex subunit 9 {ECO:0000250|UniProtKB:Q92600};
DE AltName: Full=Cell differentiation protein RQCD1 homolog;
DE Short=Rcd-1;
GN Name=cnot9 {ECO:0000250|UniProtKB:Q92600}; Synonyms=rcd1, rqcd1;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the CCR4-NOT complex which is one of the major
CC cellular mRNA deadenylases and is linked to various cellular processes
CC including bulk mRNA degradation, miRNA-mediated repression,
CC translational repression during translational initiation and general
CC transcription regulation. Additional complex functions may be a
CC consequence of its influence on mRNA expression. Involved in down-
CC regulation of MYB- and JUN-dependent transcription. Enhances ligand-
CC dependent transcriptional activity of nuclear hormone receptors. May
CC play a role in cell differentiation. {ECO:0000250|UniProtKB:Q9JKY0}.
CC -!- SUBUNIT: Homodimer. Component of the CCR4-NOT complex (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9JKY0}.
CC Cytoplasm, P-body {ECO:0000250|UniProtKB:Q9JKY0}.
CC -!- SIMILARITY: Belongs to the CNOT9 family. {ECO:0000305}.
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DR EMBL; BC072053; AAH72053.1; -; mRNA.
DR RefSeq; NP_001085150.1; NM_001091681.1.
DR RefSeq; XP_018094243.1; XM_018238754.1.
DR AlphaFoldDB; Q6IP65; -.
DR SMR; Q6IP65; -.
DR BioGRID; 101595; 1.
DR IntAct; Q6IP65; 1.
DR MaxQB; Q6IP65; -.
DR DNASU; 432229; -.
DR GeneID; 108702939; -.
DR GeneID; 432229; -.
DR KEGG; xla:108702939; -.
DR KEGG; xla:432229; -.
DR CTD; 432229; -.
DR OrthoDB; 1129961at2759; -.
DR Proteomes; UP000186698; Chromosome 9_10L.
DR Proteomes; UP000186698; Chromosome 9_10S.
DR Bgee; 108702939; Expressed in internal ear and 19 other tissues.
DR GO; GO:0030014; C:CCR4-NOT complex; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR GO; GO:0030374; F:nuclear receptor coactivator activity; ISS:UniProtKB.
DR GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
DR GO; GO:0006402; P:mRNA catabolic process; IEA:InterPro.
DR GO; GO:0033147; P:negative regulation of intracellular estrogen receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR007216; CNOT9.
DR PANTHER; PTHR12262:SF0; PTHR12262:SF0; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 2: Evidence at transcript level;
KW Activator; Cytoplasm; Nucleus; Reference proteome; Repressor;
KW RNA-mediated gene silencing; Transcription; Transcription regulation;
KW Translation regulation.
FT CHAIN 1..299
FT /note="CCR4-NOT transcription complex subunit 9"
FT /id="PRO_0000327231"
SQ SEQUENCE 299 AA; 33557 MW; 931137578953BC38 CRC64;
MHSLATAAPV PAALAQVDRE KIYQWINELS SPDTRENALL ELSKKRESVP DLAPMLWHSF
GTIAALLQEI VNIYPSINPP TLTAHQSNRV CNALALLQCV ASHPETRSAF LAAHIPLFLY
PFLHTVSKTR PFEYLRLTSL GVIGALVKTD EQEVINFLLT TEIIPLCLRI MESGSELSKT
VATFILQKIL LDDTGLAYIC QTYERFSHVA MILGKMVLQL SKEPSARLLK HVVRCYLRLS
DNPRAREALR QCLPDQLKDT TFAQVLKDDT TTKRWLAQLV KNLQEGQVTD PRGIPLPPQ
