ID   CNOT9_XENTR             Reviewed;         299 AA.
AC   Q6P819;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=CCR4-NOT transcription complex subunit 9 {ECO:0000250|UniProtKB:Q92600};
DE   AltName: Full=Cell differentiation protein RQCD1 homolog;
DE            Short=Rcd-1;
GN   Name=cnot9 {ECO:0000250|UniProtKB:Q92600}; Synonyms=rcd1, rqcd1;
GN   ORFNames=TNeu111l17.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the CCR4-NOT complex which is one of the major
CC       cellular mRNA deadenylases and is linked to various cellular processes
CC       including bulk mRNA degradation, miRNA-mediated repression,
CC       translational repression during translational initiation and general
CC       transcription regulation. Additional complex functions may be a
CC       consequence of its influence on mRNA expression. Involved in down-
CC       regulation of MYB- and JUN-dependent transcription. Enhances ligand-
CC       dependent transcriptional activity of nuclear hormone receptors. May
CC       play a role in cell differentiation. {ECO:0000250|UniProtKB:Q9JKY0}.
CC   -!- SUBUNIT: Homodimer. Component of the CCR4-NOT complex.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9JKY0}.
CC       Cytoplasm, P-body {ECO:0000250|UniProtKB:Q9JKY0}.
CC   -!- SIMILARITY: Belongs to the CNOT9 family. {ECO:0000305}.
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DR   EMBL; CR760361; CAJ82430.1; -; mRNA.
DR   EMBL; BC061412; AAH61412.1; -; mRNA.
DR   RefSeq; NP_989024.1; NM_203693.1.
DR   AlphaFoldDB; Q6P819; -.
DR   SMR; Q6P819; -.
DR   STRING; 8364.ENSXETP00000032762; -.
DR   PaxDb; Q6P819; -.
DR   DNASU; 394620; -.
DR   Ensembl; ENSXETT00000032762; ENSXETP00000032762; ENSXETG00000014984.
DR   GeneID; 394620; -.
DR   KEGG; xtr:394620; -.
DR   CTD; 9125; -.
DR   eggNOG; KOG3036; Eukaryota.
DR   HOGENOM; CLU_039962_2_0_1; -.
DR   InParanoid; Q6P819; -.
DR   OMA; SAWMHQQ; -.
DR   OrthoDB; 1129961at2759; -.
DR   PhylomeDB; Q6P819; -.
DR   TreeFam; TF105734; -.
DR   Reactome; R-XTR-429947; Deadenylation of mRNA.
DR   Reactome; R-XTR-6804115; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.
DR   Proteomes; UP000008143; Chromosome 9.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000014984; Expressed in skeletal muscle tissue and 13 other tissues.
DR   ExpressionAtlas; Q6P819; baseline.
DR   GO; GO:0030014; C:CCR4-NOT complex; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR   GO; GO:0030374; F:nuclear receptor coactivator activity; ISS:UniProtKB.
DR   GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
DR   GO; GO:0006402; P:mRNA catabolic process; IEA:InterPro.
DR   GO; GO:0033147; P:negative regulation of intracellular estrogen receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR007216; CNOT9.
DR   PANTHER; PTHR12262:SF0; PTHR12262:SF0; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Activator; Cytoplasm; Nucleus; Reference proteome; Repressor;
KW   RNA-mediated gene silencing; Transcription; Transcription regulation;
KW   Translation regulation.
FT   CHAIN           1..299
FT                   /note="CCR4-NOT transcription complex subunit 9"
FT                   /id="PRO_0000327232"
SQ   SEQUENCE   299 AA;  33557 MW;  931137578953BC38 CRC64;
     MHSLATAAPV PAALAQVDRE KIYQWINELS SPDTRENALL ELSKKRESVP DLAPMLWHSF
     GTIAALLQEI VNIYPSINPP TLTAHQSNRV CNALALLQCV ASHPETRSAF LAAHIPLFLY
     PFLHTVSKTR PFEYLRLTSL GVIGALVKTD EQEVINFLLT TEIIPLCLRI MESGSELSKT
     VATFILQKIL LDDTGLAYIC QTYERFSHVA MILGKMVLQL SKEPSARLLK HVVRCYLRLS
     DNPRAREALR QCLPDQLKDT TFAQVLKDDT TTKRWLAQLV KNLQEGQVTD PRGIPLPPQ