CNPD3_MORCB
ID CNPD3_MORCB Reviewed; 277 AA.
AC D5VAD8;
DT 19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT 13-JUL-2010, sequence version 1.
DT 03-AUG-2022, entry version 59.
DE RecName: Full=Probable cyclic nucleotide phosphodiesterase MCR_0369 {ECO:0000250|UniProtKB:P9WP65};
DE EC=3.1.4.- {ECO:0000250|UniProtKB:P9WP65};
GN OrderedLocusNames=MCR_0369;
OS Moraxella catarrhalis (strain BBH18).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Moraxella.
OX NCBI_TaxID=1236608;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BBH18;
RX PubMed=20453089; DOI=10.1128/jb.00121-10;
RA de Vries S.P., van Hijum S.A., Schueler W., Riesbeck K., Hays J.P.,
RA Hermans P.W., Bootsma H.J.;
RT "Genome analysis of Moraxella catarrhalis strain RH4, a human respiratory
RT tract pathogen.";
RL J. Bacteriol. 192:3574-3583(2010).
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000250|UniProtKB:Q6XBH1};
CC Note=Binds 2 Fe(2+) ions per subunit. {ECO:0000250|UniProtKB:Q6XBH1};
CC -!- SIMILARITY: Belongs to the cyclic nucleotide phosphodiesterase class-
CC III family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP002005; ADG60641.1; -; Genomic_DNA.
DR RefSeq; WP_003660880.1; NC_014147.1.
DR AlphaFoldDB; D5VAD8; -.
DR SMR; D5VAD8; -.
DR STRING; 1236608.MCR_0369; -.
DR EnsemblBacteria; ADG60641; ADG60641; MCR_0369.
DR GeneID; 66586170; -.
DR KEGG; mct:MCR_0369; -.
DR PATRIC; fig|1236608.7.peg.385; -.
DR HOGENOM; CLU_070320_0_0_6; -.
DR OMA; TAVFMHH; -.
DR OrthoDB; 1242748at2; -.
DR Proteomes; UP000000930; Chromosome.
DR GO; GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-UniRule.
DR Gene3D; 3.60.21.10; -; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR Pfam; PF00149; Metallophos; 1.
DR SUPFAM; SSF56300; SSF56300; 1.
PE 3: Inferred from homology;
KW Hydrolase; Iron; Metal-binding; Nucleotide-binding; Reference proteome.
FT CHAIN 1..277
FT /note="Probable cyclic nucleotide phosphodiesterase
FT MCR_0369"
FT /id="PRO_0000413369"
FT BINDING 17
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:Q6XBH1"
FT BINDING 19
FT /ligand="AMP"
FT /ligand_id="ChEBI:CHEBI:456215"
FT /evidence="ECO:0000250|UniProtKB:P9WP65"
FT BINDING 19
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:Q6XBH1"
FT BINDING 53
FT /ligand="AMP"
FT /ligand_id="ChEBI:CHEBI:456215"
FT /evidence="ECO:0000250|UniProtKB:P9WP65"
FT BINDING 53
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:Q6XBH1"
FT BINDING 53
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:Q6XBH1"
FT BINDING 83..84
FT /ligand="AMP"
FT /ligand_id="ChEBI:CHEBI:456215"
FT /evidence="ECO:0000250|UniProtKB:P9WP65"
FT BINDING 83
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:Q6XBH1"
FT BINDING 165
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:Q6XBH1"
FT BINDING 204
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:Q6XBH1"
FT BINDING 206
FT /ligand="AMP"
FT /ligand_id="ChEBI:CHEBI:456215"
FT /evidence="ECO:0000250|UniProtKB:P9WP65"
FT BINDING 206
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:Q6XBH1"
SQ SEQUENCE 277 AA; 31630 MW; D671DDEBAA0D9647 CRC64;
MPNITNNHTF NIVQLSDLHL TGDIGQAPSY QRFLAVFQTA KHLNPDLWLL TGDLVNDGNS
DAYDWLFNQL QATKIPYLAV AGNHDVTHEI GIHLAHQERI HVPILPDRRL KNCFRYTFQA
GHDWQILLLN SSVSGEIFGL LTHETLLWLD QTLTTHFEQT IIALHHHPTK VSSDWIDAHL
LKNHQDFWHV IKKHAHVHTI LCGHVHQVHT LHPLPAHQVQ LLSCPSTDRQ FMPFVDNFQI
ADTPAGCRMI QIDNKGIVSS YIQIVQNTHS FCLNNAN
