CNPY1_HUMAN
ID CNPY1_HUMAN Reviewed; 92 AA.
AC Q3B7I2; A6NGX3;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Protein canopy homolog 1;
GN Name=CNPY1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the canopy family. {ECO:0000305}.
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DR EMBL; AC009403; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH236954; EAL23910.1; -; Genomic_DNA.
DR EMBL; BC105732; AAI05733.1; -; mRNA.
DR EMBL; BC105733; AAI05734.1; -; mRNA.
DR EMBL; BC105734; AAI05735.1; -; mRNA.
DR EMBL; BC107598; AAI07599.1; -; mRNA.
DR CCDS; CCDS43684.1; -.
DR RefSeq; NP_001096646.1; NM_001103176.1.
DR AlphaFoldDB; Q3B7I2; -.
DR STRING; 9606.ENSP00000317439; -.
DR BioMuta; CNPY1; -.
DR DMDM; 121942376; -.
DR PaxDb; Q3B7I2; -.
DR PeptideAtlas; Q3B7I2; -.
DR PRIDE; Q3B7I2; -.
DR ProteomicsDB; 61653; -.
DR Antibodypedia; 49629; 10 antibodies from 8 providers.
DR DNASU; 285888; -.
DR Ensembl; ENST00000321736.5; ENSP00000317439.5; ENSG00000146910.14.
DR Ensembl; ENST00000406197.5; ENSP00000384514.1; ENSG00000146910.14.
DR GeneID; 285888; -.
DR KEGG; hsa:285888; -.
DR UCSC; uc003wmc.2; human.
DR CTD; 285888; -.
DR DisGeNET; 285888; -.
DR GeneCards; CNPY1; -.
DR HGNC; HGNC:27786; CNPY1.
DR HPA; ENSG00000146910; Tissue enriched (brain).
DR MIM; 612493; gene.
DR neXtProt; NX_Q3B7I2; -.
DR OpenTargets; ENSG00000146910; -.
DR PharmGKB; PA162382571; -.
DR VEuPathDB; HostDB:ENSG00000146910; -.
DR eggNOG; KOG3782; Eukaryota.
DR GeneTree; ENSGT00940000161119; -.
DR HOGENOM; CLU_095726_3_0_1; -.
DR InParanoid; Q3B7I2; -.
DR OrthoDB; 1417418at2759; -.
DR PhylomeDB; Q3B7I2; -.
DR PathwayCommons; Q3B7I2; -.
DR BioGRID-ORCS; 285888; 11 hits in 1062 CRISPR screens.
DR ChiTaRS; CNPY1; human.
DR GenomeRNAi; 285888; -.
DR Pharos; Q3B7I2; Tdark.
DR PRO; PR:Q3B7I2; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q3B7I2; protein.
DR Bgee; ENSG00000146910; Expressed in cerebellar hemisphere and 39 other tissues.
DR ExpressionAtlas; Q3B7I2; baseline and differential.
DR Genevisible; Q3B7I2; HS.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR InterPro; IPR042415; CNPY.
DR InterPro; IPR021852; DUF3456.
DR PANTHER; PTHR13341; PTHR13341; 1.
DR Pfam; PF11938; DUF3456; 1.
PE 3: Inferred from homology;
KW Reference proteome.
FT CHAIN 1..92
FT /note="Protein canopy homolog 1"
FT /id="PRO_0000314015"
SQ SEQUENCE 92 AA; 10960 MW; 68CD514D34EFE11F CRC64;
MNDYKLEEDP VTKERTFKRF APRKGDKIYQ EFKKLYFYSD AYRPLKFACE TIIEEYEDEI
SSLIAQETHY LADKLCSEKS DLCETSANHT EL
