ID   CNPY3_DANRE             Reviewed;         276 AA.
AC   A3KNS2; Q2L6K9; Q5XJK4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Protein canopy homolog 3;
DE   AltName: Full=Trinucleotide repeat-containing gene 5 protein;
DE   Flags: Precursor;
GN   Name=cnpy3; Synonyms=tnrc5;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX   PubMed=16488878; DOI=10.1016/j.cub.2006.01.055;
RA   Hirate Y., Okamoto H.;
RT   "Canopy1, a novel regulator of FGF signaling around the midbrain-hindbrain
RT   boundary in zebrafish.";
RL   Curr. Biol. 16:421-427(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo, and Larva;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Toll-like receptor (TLR)-specific co-chaperone for HSP90B1.
CC       Required for proper TLR folding and hence controls TLR exit from the
CC       endoplasmic reticulum. Consequently, required for immune responses (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Expressed ubiquitously at 18 hours post-
CC       fertilization (hpf). {ECO:0000269|PubMed:16488878}.
CC   -!- SIMILARITY: Belongs to the canopy family. {ECO:0000305}.
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DR   EMBL; AB201385; BAE78826.1; -; mRNA.
DR   EMBL; BC083297; AAH83297.1; -; mRNA.
DR   EMBL; BC133981; AAI33982.1; -; mRNA.
DR   RefSeq; NP_001034894.2; NM_001039805.2.
DR   AlphaFoldDB; A3KNS2; -.
DR   STRING; 7955.ENSDARP00000040115; -.
DR   PaxDb; A3KNS2; -.
DR   PeptideAtlas; A3KNS2; -.
DR   PRIDE; A3KNS2; -.
DR   GeneID; 550136; -.
DR   KEGG; dre:550136; -.
DR   CTD; 10695; -.
DR   ZFIN; ZDB-GENE-050411-12; cnpy3.
DR   eggNOG; KOG4052; Eukaryota.
DR   InParanoid; A3KNS2; -.
DR   OrthoDB; 1412562at2759; -.
DR   PhylomeDB; A3KNS2; -.
DR   Reactome; R-DRE-1679131; Trafficking and processing of endosomal TLR.
DR   PRO; PR:A3KNS2; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR021852; DUF3456.
DR   Pfam; PF11938; DUF3456; 1.
PE   2: Evidence at transcript level;
KW   Chaperone; Coiled coil; Disulfide bond; Endoplasmic reticulum; Immunity;
KW   Innate immunity; Reference proteome; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..276
FT                   /note="Protein canopy homolog 3"
FT                   /id="PRO_0000313783"
FT   DOMAIN          30..269
FT                   /note="Saposin B-type"
FT   REGION          206..276
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          137..162
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        239..268
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        32..190
FT                   /evidence="ECO:0000250"
FT   DISULFID        35..178
FT                   /evidence="ECO:0000250"
FT   DISULFID        88..150
FT                   /evidence="ECO:0000250"
FT   CONFLICT        208
FT                   /note="D -> E (in Ref. 2; AAH83297)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        216
FT                   /note="K -> N (in Ref. 1; BAE78826)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        251
FT                   /note="M -> T (in Ref. 1; BAE78826)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   276 AA;  31458 MW;  784F91EC2937610A CRC64;
     MNVFISVVLF LGSARAASKT GDDEWVHLPN KCEVCKFVSI EMKSAFDETG KTKEVIDTNY
     RFLDDKGAPP IKYVKSDIRF IEVTENVCSR IMQYNLHKER DGSNRFAKGM SETFSTLHNL
     VNKGVKVVMD IPYELWNETS AEVADLKKQC DVMVEQYEDV IEDWYKGSQE EDLTTYLCEK
     HVLKGQDTGC LKETWAGKKG DMAAIAEDKK KKKGKKKKGK DGEDGQKKEK KVKKKKKKSK
     ISDSESSKRR MEAAGFTSDE EEIQKKVPLN QPKTEL