ID   CNPY3_PIG               Reviewed;         283 AA.
AC   A5GFQ5;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Protein canopy homolog 3;
DE   AltName: Full=Trinucleotide repeat-containing gene 5 protein;
DE   Flags: Precursor;
GN   Name=CNPY3; Synonyms=TNRC5;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Porcine genome sequencing project;
RL   Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Toll-like receptor (TLR)-specific co-chaperone for HSP90B1.
CC       Required for proper TLR folding, except that of TLR3, and hence
CC       controls TLR exit from the endoplasmic reticulum. Consequently,
CC       required for both innate and adaptive immune responses (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with HSP90B1; this interaction is disrupted in the
CC       presence of ATP. Interacts with TLR1, TLR2, TLR4 and TLR9 (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the canopy family. {ECO:0000305}.
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DR   EMBL; CR956379; CAN13167.1; -; Genomic_DNA.
DR   RefSeq; NP_001103898.1; NM_001110428.1.
DR   AlphaFoldDB; A5GFQ5; -.
DR   STRING; 9823.ENSSSCP00000001789; -.
DR   PaxDb; A5GFQ5; -.
DR   PeptideAtlas; A5GFQ5; -.
DR   PRIDE; A5GFQ5; -.
DR   Ensembl; ENSSSCT00000001836; ENSSSCP00000001789; ENSSSCG00000001651.
DR   Ensembl; ENSSSCT00025060800; ENSSSCP00025025793; ENSSSCG00025044824.
DR   Ensembl; ENSSSCT00030086678; ENSSSCP00030039977; ENSSSCG00030061968.
DR   Ensembl; ENSSSCT00040055434; ENSSSCP00040023041; ENSSSCG00040041282.
DR   Ensembl; ENSSSCT00045011443; ENSSSCP00045007798; ENSSSCG00045006843.
DR   Ensembl; ENSSSCT00050005888; ENSSSCP00050002555; ENSSSCG00050004271.
DR   Ensembl; ENSSSCT00055033182; ENSSSCP00055026431; ENSSSCG00055016837.
DR   Ensembl; ENSSSCT00060084302; ENSSSCP00060036526; ENSSSCG00060061785.
DR   Ensembl; ENSSSCT00065109973; ENSSSCP00065049488; ENSSSCG00065079136.
DR   Ensembl; ENSSSCT00070000928; ENSSSCP00070000811; ENSSSCG00070000496.
DR   GeneID; 100126290; -.
DR   KEGG; ssc:100126290; -.
DR   CTD; 10695; -.
DR   VGNC; VGNC:86841; CNPY3.
DR   eggNOG; KOG4052; Eukaryota.
DR   GeneTree; ENSGT00390000014072; -.
DR   HOGENOM; CLU_078068_0_0_1; -.
DR   InParanoid; A5GFQ5; -.
DR   OMA; DKACLDE; -.
DR   OrthoDB; 1412562at2759; -.
DR   TreeFam; TF318951; -.
DR   Reactome; R-SSC-1679131; Trafficking and processing of endosomal TLR.
DR   Proteomes; UP000008227; Chromosome 7.
DR   Proteomes; UP000314985; Chromosome 7.
DR   Bgee; ENSSSCG00000001651; Expressed in right lobe of liver and 43 other tissues.
DR   ExpressionAtlas; A5GFQ5; baseline and differential.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR021852; DUF3456.
DR   Pfam; PF11938; DUF3456; 1.
PE   3: Inferred from homology;
KW   Chaperone; Coiled coil; Endoplasmic reticulum; Glycoprotein; Immunity;
KW   Innate immunity; Reference proteome; Signal.
FT   SIGNAL          1..35
FT                   /evidence="ECO:0000255"
FT   CHAIN           36..283
FT                   /note="Protein canopy homolog 3"
FT                   /id="PRO_0000313782"
FT   DOMAIN          55..276
FT                   /note="Saposin B-type"
FT   REGION          223..283
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          161..187
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        253..271
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        161
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   283 AA;  31710 MW;  2734DDDD2D273638 CRC64;
     MEPLPEPTSR PRLRPRPRCL LLLPLLLLLL LLLPAPELGP REARAEETDW VRLPSKCEVC
     KYVAVELKSA FEETGKTKEV IDTGYGILDR KASGVKYTKS DLRLIEVTET ICKRLLDYSL
     HKERTGSNRF AKGMSETFET LHNLVHKGVK VVMDIPYELW NETSAEVADL KKQCDVLVEE
     FEEVIEDWYR NHQEEDLTQF LCANHVLKGK DTSCLAEQWS GKKGDTAALG GKKSKKKSSR
     AKASGGGSKQ RKELGGIEGD PSPEEDEGIQ KASPLTHSPP DEL