CNPY3_XENLA
ID CNPY3_XENLA Reviewed; 243 AA.
AC Q6GN40;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 03-AUG-2022, entry version 51.
DE RecName: Full=Protein canopy homolog 3;
DE Flags: Precursor;
GN Name=cnpy3;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Toll-like receptor (TLR)-specific co-chaperone for HSP90B1.
CC Required for proper TLR folding and hence controls TLR exit from the
CC endoplasmic reticulum. Consequently, required for immune responses (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the canopy family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH73680.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; BC073680; AAH73680.1; ALT_INIT; mRNA.
DR RefSeq; XP_018118274.1; XM_018262785.1.
DR AlphaFoldDB; Q6GN40; -.
DR GeneID; 443685; -.
DR KEGG; xla:443685; -.
DR CTD; 443685; -.
DR Xenbase; XB-GENE-6251984; cnpy3.L.
DR OMA; DKACLDE; -.
DR OrthoDB; 1412562at2759; -.
DR Proteomes; UP000186698; Chromosome 5L.
DR Bgee; 443685; Expressed in gastrula and 19 other tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR InterPro; IPR021852; DUF3456.
DR Pfam; PF11938; DUF3456; 1.
PE 2: Evidence at transcript level;
KW Chaperone; Coiled coil; Disulfide bond; Endoplasmic reticulum; Immunity;
KW Innate immunity; Reference proteome; Signal.
FT SIGNAL 1..15
FT /evidence="ECO:0000255"
FT CHAIN 16..243
FT /note="Protein canopy homolog 3"
FT /id="PRO_0000313784"
FT DOMAIN 27..236
FT /note="Saposin B-type"
FT REGION 186..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 136..160
FT /evidence="ECO:0000255"
FT COMPBIAS 186..200
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..243
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 29..188
FT /evidence="ECO:0000250"
FT DISULFID 32..176
FT /evidence="ECO:0000250"
FT DISULFID 86..148
FT /evidence="ECO:0000250"
SQ SEQUENCE 243 AA; 28170 MW; 58A8B3DA628BDB8C CRC64;
MWFLFLLLPL WAGCAEPGDS EWVHLPSKCE VCKYVALELK SSFDETSRTR ELIDTRYGFL
EDDKKKKKIK YTTSDIRLIE VTEGLCSRLL EYNLHKERTG SNRFAKGMSE TFQTLHHLVH
KGVKVVMDIP YELWNETSAE VADMKKQCDV MMENYEEVIE DWYRNHQDED LSEFLCARHV
LKGQDQSCLS EQGDSRKGDT GPSTGTKKQK KQGEKKNKSK KQNSGSKEEK KQMDQPMAAK
EEL