ID   CNPY3_XENTR             Reviewed;         242 AA.
AC   Q5HZV5;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=Protein canopy homolog 3;
DE   Flags: Precursor;
GN   Name=cnpy3;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Toll-like receptor (TLR)-specific co-chaperone for HSP90B1.
CC       Required for proper TLR folding and hence controls TLR exit from the
CC       endoplasmic reticulum. Consequently, required for immune responses (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the canopy family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH88872.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC088872; AAH88872.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; Q5HZV5; -.
DR   InParanoid; Q5HZV5; -.
DR   Proteomes; UP000008143; Genome assembly.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR021852; DUF3456.
DR   Pfam; PF11938; DUF3456; 1.
PE   2: Evidence at transcript level;
KW   Chaperone; Disulfide bond; Endoplasmic reticulum; Immunity;
KW   Innate immunity; Reference proteome; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..242
FT                   /note="Protein canopy homolog 3"
FT                   /id="PRO_0000313785"
FT   DOMAIN          26..235
FT                   /note="Saposin B-type"
FT   REGION          191..242
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        28..187
FT                   /evidence="ECO:0000250"
FT   DISULFID        31..175
FT                   /evidence="ECO:0000250"
FT   DISULFID        85..147
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   242 AA;  28120 MW;  985D24FBD48EC41E CRC64;
     MWLLLLLPLW GGCAEPGDSE WVNLPSKCEV CKYVALELKS SFDETSRTRE LIDTRYGFLE
     DDKKAKKIKY TNSDIRLIEV TEGLCSRLLE YNLHKERSGS NRFAKGMSET FQTLHHLVHK
     GVKVVMDIPY ELWNETSAEV ADMKKQCDVM METYEDVIED WYRHHQEADL TEFLCARHVL
     RGQDQSCLEE HWDSRKGDTG PSTGTKKQKK QGEKKNKSKK ENSGPEEERR QMEQPTAAKE
     EL