ID   CNPY4_BOVIN             Reviewed;         239 AA.
AC   Q3SWX1;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Protein canopy homolog 4;
DE   Flags: Precursor;
GN   Name=CNPY4;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in the regulation of the cell surface expression
CC       of TLR4. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with TLR4. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the canopy family. {ECO:0000305}.
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DR   EMBL; BC104626; AAI04627.1; -; mRNA.
DR   RefSeq; NP_001029425.1; NM_001034253.2.
DR   AlphaFoldDB; Q3SWX1; -.
DR   STRING; 9913.ENSBTAP00000037026; -.
DR   PaxDb; Q3SWX1; -.
DR   PeptideAtlas; Q3SWX1; -.
DR   PRIDE; Q3SWX1; -.
DR   Ensembl; ENSBTAT00000037188; ENSBTAP00000037026; ENSBTAG00000007016.
DR   GeneID; 505637; -.
DR   KEGG; bta:505637; -.
DR   CTD; 245812; -.
DR   VEuPathDB; HostDB:ENSBTAG00000007016; -.
DR   VGNC; VGNC:27528; CNPY4.
DR   eggNOG; KOG4052; Eukaryota.
DR   GeneTree; ENSGT00390000014072; -.
DR   HOGENOM; CLU_078068_0_1_1; -.
DR   InParanoid; Q3SWX1; -.
DR   OMA; TISDWYF; -.
DR   OrthoDB; 1412562at2759; -.
DR   TreeFam; TF318951; -.
DR   Proteomes; UP000009136; Chromosome 25.
DR   Bgee; ENSBTAG00000007016; Expressed in granulosa cell and 106 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR   GO; GO:1903078; P:positive regulation of protein localization to plasma membrane; IEA:Ensembl.
DR   InterPro; IPR021852; DUF3456.
DR   Pfam; PF11938; DUF3456; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..239
FT                   /note="Protein canopy homolog 4"
FT                   /id="PRO_0000314017"
FT   REGION          199..239
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        224..239
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        37..195
FT                   /evidence="ECO:0000250"
FT   DISULFID        40..183
FT                   /evidence="ECO:0000250"
FT   DISULFID        93..155
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   239 AA;  27369 MW;  72713EF107EC91CE CRC64;
     MGPVRLGTLL FILTVYGAWA GTPKEEEDDT ERLPSKCEVC KLLSLELQEE LSRTGRSREV
     LELGQVLDTG KRKRHIPYSV SETRLEEALE NLCERILDYS VHAERKGSLR YAKGQSQTMA
     TLKGLVQKGV KVDLGIPLEL WDEPSVEVTF LKKQCETMLE QFEDVVGDWY FHHQEQPLQH
     FLCEGHVLPA SETACLQETW TGKEKITDGQ EKTEEEEQDQ EEEEMTNTPV HSQHDPEDL