ID   CNPY4_DANRE             Reviewed;         217 AA.
AC   Q2L6K8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Protein canopy 4;
DE   Flags: Precursor;
GN   Name=cnpy4;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX   PubMed=16488878; DOI=10.1016/j.cub.2006.01.055;
RA   Hirate Y., Okamoto H.;
RT   "Canopy1, a novel regulator of FGF signaling around the midbrain-hindbrain
RT   boundary in zebrafish.";
RL   Curr. Biol. 16:421-427(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: Expressed ubiquitously at 18 hours post-
CC       fertilization (hpf). {ECO:0000269|PubMed:16488878}.
CC   -!- SIMILARITY: Belongs to the canopy family. {ECO:0000305}.
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DR   EMBL; AB201386; BAE78827.1; -; mRNA.
DR   EMBL; BC121734; AAI21735.1; -; mRNA.
DR   EMBL; BC152092; AAI52093.1; -; mRNA.
DR   RefSeq; NP_001034602.1; NM_001039513.1.
DR   AlphaFoldDB; Q2L6K8; -.
DR   STRING; 7955.ENSDARP00000072654; -.
DR   PaxDb; Q2L6K8; -.
DR   Ensembl; ENSDART00000078192; ENSDARP00000072654; ENSDARG00000055797.
DR   GeneID; 568776; -.
DR   KEGG; dre:568776; -.
DR   CTD; 245812; -.
DR   ZFIN; ZDB-GENE-060315-5; cnpy4.
DR   eggNOG; KOG4052; Eukaryota.
DR   GeneTree; ENSGT00390000014072; -.
DR   HOGENOM; CLU_078068_0_1_1; -.
DR   InParanoid; Q2L6K8; -.
DR   OMA; TISDWYF; -.
DR   OrthoDB; 1412562at2759; -.
DR   PhylomeDB; Q2L6K8; -.
DR   TreeFam; TF318951; -.
DR   PRO; PR:Q2L6K8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 7.
DR   Bgee; ENSDARG00000055797; Expressed in swim bladder and 27 other tissues.
DR   ExpressionAtlas; Q2L6K8; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR   InterPro; IPR021852; DUF3456.
DR   Pfam; PF11938; DUF3456; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..217
FT                   /note="Protein canopy 4"
FT                   /id="PRO_0000314020"
FT   REGION          194..217
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        27..185
FT                   /evidence="ECO:0000250"
FT   DISULFID        30..173
FT                   /evidence="ECO:0000250"
FT   DISULFID        83..145
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   217 AA;  25222 MW;  56B3106EAD04E322 CRC64;
     MEMFTVFLFY MFSLVLANQE ERLPNKCEVC KLLTVELQDA LDKTGRSKEV VELGEVLDTG
     KRRRKIKYNT SEMRLTEAMD NICERILQYK VHAERPGSLR YAKGTSQTMN TLKNLVEKGV
     KVELGVPYEL WDEPTVEVAE LKRQCETMLE EHEEVVEDWY FHHQDKGLER FFCEAHVLKD
     SDQECLTEIW KGDMGMKGSE EESEGKDGKE THDAGEL